Biophysical and ultrasonographic changes in lichen planus compared with uninvolved skin

Yazdanparast, Taraneh; Yazdani, Kamran; Humbert, Philippe; Khatami, Alireza; Nasrollahi, Saman Ahmad; Zartab, Hamed; Firouzabadi, Leila Izadi; Firooz, Alireza

doi:10.1016/j.ijwd.2018.10.001

Cited by 9 publications

(11 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Elevated pH has been demonstrated in different types of dermatitis and lichen planus previously, too. 16,17 Elevated erythema and melanin are also shown in lichen planus lesions 17 ; according to the results of this study, these findings were seen in parapsoriasis/mycosis fungoides lesions too. Majority of the classical case of MF clinically present with an erythematous scaly patch and the microscopic dermal features include the pigment incontinence, 18 and these characteristics justify elevated erythema and melanin in biometric evaluation of parapsoriasis/mycosis fungoides lesions.…”

Section: Discussionsupporting

confidence: 58%

Biophysical and ultrasonographic changes in early patch/plaque stage of mycosis fungoides, compared with uninvolved skin

Yazdanparast

Yazdani

Nasrollahi

et al. 2021

Skin Research and Technology

Self Cite

View full text Add to dashboard Cite

Mycosis fungoides (MF) is the most prevalent cutaneous T-cell lymphoma and mimics benign inflammatory processes (clinically and histologically) in the early stages, so its diagnosis is difficult. Meanwhile, there is disagreement concerning whether parapsoriasis is a chronic benign condition with similar clinical and histological characteristics as MF, or it is part of the disease spectrum. 1 One belief is that large plaque parapsoriasis (LPP) should be classified as early patch stage of MF, although there are no definite clinical or laboratory criteria to predict which LPP will progress to MF. 2 Fast diagnosis of MF is significant for decision about type of therapy, prognosis, and follow-up. However, there is no consensus on criteria for diagnosing the disease early. 2 The diagnosis of MF simply by clinical, histological, and immunohistochemical signs amounts to 50%-75% accuracy. For comprehensive diagnosis of MF, the assessment of clinical, anamnestic, histological, immunophenotypic and molecular genetic data are needed. 3

show abstract

Section: Discussionsupporting

confidence: 58%

Biophysical and ultrasonographic changes in early patch/plaque stage of mycosis fungoides, compared with uninvolved skin

Yazdanparast

Yazdani

Nasrollahi

et al. 2021

Skin Research and Technology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Ultrasound has been used to quantify epidermal thickness in lichen planus and psoriasis (15, 16). Epidermal thickness, as measured by ultrasound, demonstrates correlation with the maximum depth of rete ridges in histological specimens (17).…”

Section: Resultsmentioning

confidence: 99%

A Scoping Review of Non-invasive Imaging Modalities in Dermatological Disease: Potential Novel Biomarkers in Hidradenitis Suppurativa

2019

View full text Add to dashboard Cite

Background: The development of imaging-based biomarkers has the potential to overcome major challenges in the accurate and reproducible assessment of disease severity and response to novel therapies in Hidradenitis Suppurativa (HS). Understanding the advantages and limitations of existing non-invasive imaging modalities in dermatological disease will aid in the development of hypotheses and inform the design of future studies.Methods: A scoping review was performed using Medline, Embase, Web of Science Databases and evaluation of “gray literature” until June 30, 2019. Citations were examined according to pre-defined inclusion and exclusion criteria. Citations were reviewed by two independent reviewers. Narrative Synthesis was used to summarize data, structured by imaging modality.Results: Non-invasive imaging modalities, such as ultrasound, MRI, RCM, EIS, OCT, and MIT, were identified. Only ultrasound, MRI and MIT have been used in HS. Image modalities vary in image depth, resolution, cost, accessibility and correlation with known aspects of disease activity in HS.Discussion and Conclusion: The benefits and limitations of each imaging modality are products of cost, accessibility, validity and reliability. An additional hurdle to the development of image-based biomarkers in HS is a lack of established analytical benchmarks that can be correlated with existing biological, inflammatory and clinical parameters. This review has identified potential imaging biomarkers, as well as relevant analytical benchmarks that reflect the presence or absence of disease. Further investigation work is needed to analytically and clinically validate these imaging variables in order to identify potential imaging biomarkers in HS.

show abstract

“…Skin pH was significantly higher in CL lesions compared with control sites. High pH occurs in impaired skin such as pityriasis rosea, lichen planus and chronic dermatitis lesions 13–16 and is frequently associated with high TEWL which itself is associated with low hydration 25 …”

Section: Discussionmentioning

confidence: 99%

“…These non‐invasive techniques have been used to evaluate ultrasonographic and biophysical properties in certain dermatologic diseases such as dermatitis, lichen planus, psoriasis, and pityriasis rosea 13–16 and have also been used for differentiation of these papulosquamous skin diseases 17…”

Section: Introductionmentioning

confidence: 99%

“…10 Although previous studies have considered the erythema and temperature of skin as the essential markers of inflammation in dermatologic diseases, 11,12 it is shown that for complete evaluation of the epidermal barrier status, assessment of skin surface pH, trans epidermal water loss (TEWL), and stratum corneum (SC) hydration, is also helpful. 10 These non-invasive techniques have been used to evaluate ultrasonographic and biophysical properties in certain dermatologic diseases such as dermatitis, lichen planus, psoriasis, and pityriasis rosea [13][14][15][16] and have also been used for differentiation of these papulosquamous skin diseases. 17 Ultrasound has also been widely used since 1982 for determination of epidermal and dermal thickness and echo-density.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Biophysical and ultrasonographic changes of acute Old World cutaneous leishmaniasis skin lesions in comparison with uninvolved skin: A possible tool for non‐invasive early detection and treatment outcome assessment

Khatami

Yazdanparast

Nasrollahi

et al. 2022

Dermatologic Therapy

Self Cite

View full text Add to dashboard Cite

Cutaneous leishmaniasis (CL) is a skin disease caused by intracellular protozoa, which is endemic in Iran. The goal of this study was to compare biophysical characteristics in CL lesions with uninvolved skin. Stratum corneum hydration, transepidermal water loss, surface friction, pH, sebum, melanin, erythema, temperature, elasticity parameters (R0, R2, and R5), thickness and echo-density of epidermis and dermis were measured on the active erythematous indurated part of a typical CL lesion in 20 patients, and compared with the same location on the other side of the body as control. Paired t-test was used for statistical analyses and a p < 0.05 was considered significant. Melanin content, R2 and echo-density of dermis were significantly lower, whereas transepidermal water loss, friction index, pH, erythema index, temperature, and the thickness of dermis were significantly higher in CL lesions. There was no significant difference in stratum corneum hydration, sebum, R0, R5, thickness of epidermis, and density of epidermis between CL and normal skin. CL lesions are characterized by certain changes in biophysical and ultrasonographic properties, which are mostly correlated with histological features. These changes are likely to be useful in the noninvasive early detection of CL and also as treatment outcome measures for clinical trials of new treatment modalities for CL in the future.

show abstract

Biophysical and ultrasonographic changes in lichen planus compared with uninvolved skin

Cited by 9 publications

References 34 publications

Biophysical and ultrasonographic changes in early patch/plaque stage of mycosis fungoides, compared with uninvolved skin

Biophysical and ultrasonographic changes in early patch/plaque stage of mycosis fungoides, compared with uninvolved skin

A Scoping Review of Non-invasive Imaging Modalities in Dermatological Disease: Potential Novel Biomarkers in Hidradenitis Suppurativa

Biophysical and ultrasonographic changes of acute Old World cutaneous leishmaniasis skin lesions in comparison with uninvolved skin: A possible tool for non‐invasive early detection and treatment outcome assessment

Contact Info

Product

Resources

About