Biophysical mechanism-mediated time-dependent effect on sperm of human and monkey vas implanted polyelectrolyte contraceptive

Abstract

The findings provide a means of causing such changes in the sperm that inhibit the fertilizing ability before the nucleus is affected. Therefore achieving non-obstructive vas-based contraception, without genotoxic or teratogenic effects caused by infertile sperm passing into the semen, is feasible.

Effect of γ-dose rate and total dose interrelation on the polymeric hydrogel: A novel injectable male contraceptive

“…inside the vas tube (Guha et al, 1985;Guha, 2007).The contraceptive has been proved to be safe (Manivannan et al, 2005), antimicrobial (Sharma et al, 2003;Guha, 2005), long-term effective (Chaudhury et al, 2002;Jha et al, 2009a) and reversible (Lohiya et al, 2000). Non-invasive reversibility of SMA analogues under guidance of electromagnetic field is also possible (Jha et al, 2009b).…”

An emerging interface between life science and nanotechnology: present status and prospects of reproductive healthcare aided by nano-biotechnology

“…The use of nanotechnology in the field of reproductive biomedicine can revolutionize the way we detect and treat damage to the human body and disease, and many techniques only imagined a few years ago are making remarkable progress towards becoming realities. For instance, this paper has described a range of antimicrobial, long-term, stable, single-use male and female injectable contraceptives being developed like RISUG in advanced phase III clinical trials (137, 138); and its nanotechnological versions like Smart RISUG (13–17). …”

Advances in Male Contraception

“…Unfortunately, although RISUG denotes "reversible inhibition of sperm under guidance," to date both preclinical and clinical studies have failed to demonstrate reversibility, and the mechanism whereby this might be achieved is not clear. More recent reports from this group have suggested that exposure to the styrene maleic anhydride-dimethylsulfoxide combination within the vas deferens results in irreversible alterations of the sperm membrane via changing the electrostatic and pH environments (371)(372)(373). Resulting immediate changes in sperm motility and function, if demonstrated clinically, might give such a method an advantage over vasectomy by shortening the postprocedure time to contraceptive efficacy.…”