This Editorial (vol. 15 issue 1-Regular Issue featuring an Issue Focus on the "100 th Anniversary of Har Gobind Khorana") first describes the issue contents before providing both, a look back at some journal highlights from 2022, and a look forward to what we can expect from 2023. The Editorial closes with a roundup of new journal access features and an acknowledgement of those supporting the journal.As we take our first steps into the new year, we use this moment of transition to educate the readers of Biophysical Reviews about the journal, what we are trying to achieve, and how we are doing it.