Biophysical study on the interaction of cartap hydrochloride and hemoglobin: Heme degradation and functional changes of protein

Emadi, Mahdieh; Maghami, Parvaneh; Khorsandi, Khatereh; Hosseinzadeh, Reza

doi:10.1002/jbt.22325

Cited by 14 publications

(8 citation statements)

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“…Besides, this group is responsible for the red color of blood. [29][30][31] Therefore, preserving the hemoglobin structure is necessary to transfer oxygen to the organs and cells in the body. Concerning UV-Vis experiments shown in Fig.…”

Section: Discussionmentioning

confidence: 99%

Reactive Oxygen Spices Scavenging Behavior of Selenium Upon Vinyl Chloride Interaction With Hemoglobin

Oushani

Valipour

Maghami

2021

Preprint

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BackgroundVinyl chloride (VC) a colorless gas with a pleasant odor that is capable of entering the body through oral or inhalation routes. Extensive studies on this compound indicated that it is a carcinogen, and Vinyl chloride exposure can result in a specific type of cancer in VC workers. Whereas hemoglobin plays a vital role in oxygen transfer throughout the body, the effect of VC on human hemoglobin has not been studied in a molecular aspect. Furthermore, selenium as an antioxidant is a vital factor for the health of humans and animals. Therefore, the effect of the antioxidant capability of selenium on the interaction between vinyl chloride and hemoglobin was studied.MethodsThe effect of the antioxidant capability of selenium on the interaction between VC and hemoglobin was investigated by different spectroscopy methods such as UV-visible, Fourier-transform infrared, chemiluminescence, and fluorescence spectroscopies and molecular dockingResultsThe results indicated the destruction of hemoglobin structure in the presence of different concentrations of vinyl chloride, but in the presence of selenium, the damaging effect of VC on hemoglobin structure was decreased, relying on its antioxidant capability results.ConclusionsAccording to our findings, vinyl chloride destroyed hemoglobin structure utilizing ROS production, and the presence of selenium as an antioxidant inhibits the destroying effect of vinyl chloride on hemoglobin

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Section: Discussionmentioning

confidence: 99%

Reactive Oxygen Spices Scavenging Behavior of Selenium Upon Vinyl Chloride Interaction With Hemoglobin

Oushani

Valipour

Maghami

2021

Preprint

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“…Also, based on thermodynamic analysis (Figure 7), HB's stability is reduced in the presence of Cartap. According to the [24]. (c) UV-Vis spectral changes and blue shift in Q bands due to interaction with different concentrations of Cartap hydrochloride with hemoglobin [24].…”

Section: Figure 2 (A) Ligplot Analysis Of the Interaction Between Tep...mentioning

confidence: 99%

Biological and Molecular Effects of Pesticides on Human Health

Doroudian¹,

Emadi²,

Hosseinzadeh³

et al. 2022

Pesticides - Updates on Toxicity, Efficacy and Risk Assessment

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Pesticides are widely used in agriculture and are practical and economical to improve the quality of food safety for the permanent population around the world. Even though insecticides are beneficial to cropping views, their extensive use may result in severe consequences due to their biocompatible and permanent nature. Various pesticides can cause serious health risks of direct or indirectly contaminated air, water, soil, and the general ecosystem. The effect of pesticides on blood in the mammalian cell is significant because blood can act as a target and carrier for pesticides. However, the mechanism by which they bind to biopolymers, particularly blood proteins, is not clearly understood yet. This chapter investigates the molecular effects of pesticides on biomacromolecules, especially hemoglobin.

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“…Cloridrato de cartape Efeito hemolítico (Emadi et al, 2019), bloqueador neuromuscular (letal em baixas doses) (Kalyaniwala et al, 2016).…”

Section: Captanaunclassified

Agrotóxicos: críticas à regulação que permite o envenenamento do país

Hess

Nodari

Lopes-Ferreira

2021

Desenvolv. Meio Ambiente

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O artigo contém uma análise das autorizações para a comercialização e o consumo de agrotóxicos no país na última década, bem como os seus efeitos na saúde humana e no meio ambiente. No período entre 2010 e 2018, a quantidade de agrotóxicos comercializados no Brasil aumentou mais do que o dobro do que cresceu a área cultivada no país. A permissividade da gestão de agrotóxicos no Brasil é ilustrada pelo fato de que, do total de ingredientes ativos químicos com registro no país em julho de 2020, 121 (30%) não tinham uso permitido na União Europeia (EU). A razão da proibição do uso na EU dos produtos autorizados no Brasil, no período referido, está associada aos efeitos adversos a humanos e a outros organismos resultantes da exposição aos ingredientes químicos de agrotóxicos, já descritos na literatura científica. Soja, milho, algodão e cana-de-açúcar constam entre as culturas que tiveram o maior número de novos agrotóxicos com uso autorizado no Brasil entre janeiro de 2019 e junho de 2020. Outra falta de rigor na gestão de agrotóxicos é ilustrada pela deriva, que causa danos agudos e crônicos a terceiros. Adicionalmente, a fragilidade da norma brasileira refere-se ao estabelecimento de um valor de dose, abaixo da qual eles seriam seguros. Contudo, resultados experimentais de estudos mostraram, por exemplo, que os agrotóxicos à base de glifosato, melation e piriproxifem causaram a morte de embriões de peixes em apenas 24 horas de exposição, independentemente da concentração utilizada, desafiando assim a hipótese de que existe dose segura para a exposição a tais produtos. Dessa forma, é urgente não só aumentar o rigor científico dos estudos sobre o tema, mas também promover a participação pública nas tomadas de decisão, garantindo o acesso a todas as informações contidas nos dossiês que acompanham as solicitações de registro e de autorização dos agrotóxicos.

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Biophysical study on the interaction of cartap hydrochloride and hemoglobin: Heme degradation and functional changes of protein

Cited by 14 publications

References 40 publications

Reactive Oxygen Spices Scavenging Behavior of Selenium Upon Vinyl Chloride Interaction With Hemoglobin

Reactive Oxygen Spices Scavenging Behavior of Selenium Upon Vinyl Chloride Interaction With Hemoglobin

Biological and Molecular Effects of Pesticides on Human Health

Agrotóxicos: críticas à regulação que permite o envenenamento do país

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