Biopolymers and Cells

Calvert, Paul; Boland, Thomas

doi:10.1002/9781118452943.ch12

Cited by 4 publications

(1 citation statement)

References 105 publications

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“…An inkjet bioprinter delivers small droplets of bioink (1-100 picoliters; 10-50 μm diameter) [16,22] on predefined locations of a substrate. The two most commonly used methods for inkjet printing of cells are piezoelectric and thermal inkjet bioprinting [6,23,24]. The piezoelectric inkjet printer uses piezoelectric crystals to produce acoustic waves to force the liquid in small amounts through the nozzle [16,[25][26][27][28].…”

Section: Inkjet Bioprintingmentioning

confidence: 99%

Bioink properties before, during and after 3D bioprinting

et al. 2016

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Bioprinting is a process based on additive manufacturing from materials containing living cells. These materials, often referred to as bioink, are based on cytocompatible hydrogel precursor formulations, which gel in a manner compatible with different bioprinting approaches. The bioink properties before, during and after gelation are essential for its printability, comprising such features as achievable structural resolution, shape fidelity and cell survival. However, it is the final properties of the matured bioprinted tissue construct that are crucial for the end application. During tissue formation these properties are influenced by the amount of cells present in the construct, their proliferation, migration and interaction with the material. A calibrated computational framework is able to predict the tissue development and maturation and to optimize the bioprinting input parameters such as the starting material, the initial cell loading and the construct geometry. In this contribution relevant bioink properties are reviewed and discussed on the example of most popular bioprinting approaches. The effect of cells on hydrogel processing and vice versa is highlighted. Furthermore, numerical approaches were reviewed and implemented for depicting the cellular mechanics within the hydrogel as well as for prediction of mechanical properties to achieve the desired hydrogel construct considering cell density, distribution and material-cell interaction.

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Section: Inkjet Bioprintingmentioning

confidence: 99%

Bioink properties before, during and after 3D bioprinting

et al. 2016

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Physics of bioprinting

Shafiee

Ghadiri

Ramesh

et al. 2019

Applied Physics Reviews

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Bioprinters are being extensively used for different applications in life sciences and medicine in general and more specifically in regenerative medicine, tissue, and organ fabrication. The technology has matured from its purely academic origin owing to the involvement of materials science, engineering, biology, and physics, as well as commercial entities. Nevertheless, despite the progress in the science and the understanding of the mechanisms underlying the various bioprinting technologies, further efforts are needed to develop more quantitative strategies. In particular, predictive modeling is necessary to optimize the printing parameters and thus enhance the quality of the final products. Here, we review the physics that underpins the most commonly employed approaches, such as extrusion, laser-based, and inkjet bioprinting. We provide an overview of the relevant parameters, their inter-relationships, and the equations that govern the various printing processes and thus allow for their optimization. We present our perspective on the field and views on future strategies for its further advancement. Our intention with this review is to provide the practitioners of bioprinting with additional tools to enhance the quantitative aspects of their work and move the technology beyond its early, mostly “trial and error” character.

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Dynamics of ion-phosphate lattice of DNA in left-handed double helix form

Perepelytsya¹,

Волков²

2013

Preprint

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Biopolymers and Cells

Cited by 4 publications

References 105 publications

Bioink properties before, during and after 3D bioprinting

Bioink properties before, during and after 3D bioprinting

Physics of bioprinting

Dynamics of ion-phosphate lattice of DNA in left-handed double helix form

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