Bioprintable tough hydrogels for tissue engineering applications

Dorishetty, Pramod; Dutta, Naba K.; Choudhury, Namita Roy

doi:10.1016/j.cis.2020.102163

Cited by 90 publications

(66 citation statements)

References 122 publications

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“…Bioink printability, i.e., the ability to deposit/form stable and viable volumes of material, plays a critical role in the fabrication process. Characterization, tuning, and optimization of bioprintability require an in-depth understanding the flow behavior of the bioink, such as viscosity and shear thinning [ 8 ]. To date, a variety of bioink solutions have been commercialized in a variety of biomedical applications ( Table 1 ).…”

Section: Introductionmentioning

confidence: 99%

Bioprintability: Physiomechanical and Biological Requirements of Materials for 3D Bioprinting Processes

et al. 2020

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Three-dimensional (3D) bioprinting is an additive manufacturing process that utilizes various biomaterials that either contain or interact with living cells and biological systems with the goal of fabricating functional tissue or organ mimics, which will be referred to as bioinks. These bioinks are typically hydrogel-based hybrid systems with many specific features and requirements. The characterizing and fine tuning of bioink properties before, during, and after printing are therefore essential in developing reproducible and stable bioprinted constructs. To date, myriad computational methods, mechanical testing, and rheological evaluations have been used to predict, measure, and optimize bioinks properties and their printability, but none are properly standardized. There is a lack of robust universal guidelines in the field for the evaluation and quantification of bioprintability. In this review, we introduced the concept of bioprintability and discussed the significant roles of various physiomechanical and biological processes in bioprinting fidelity. Furthermore, different quantitative and qualitative methodologies used to assess bioprintability will be reviewed, with a focus on the processes related to pre, during, and post printing. Establishing fully characterized, functional bioink solutions would be a big step towards the effective clinical applications of bioprinted products.

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Section: Introductionmentioning

confidence: 99%

Bioprintability: Physiomechanical and Biological Requirements of Materials for 3D Bioprinting Processes

et al. 2020

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“…The β-sheet nanocrystals of silk fibroin can be melted under heating without degradation, which is promising for thermal processing of solid silk fibroin materials, analogous to widely used thermoplastics. All of the above features make silk fibroin an intriguing ink component for three-dimensional (3D) printing/additive manufacturing [ 2 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Photo-Crosslinked Silk Fibroin for 3D Printing

Sahoo

Cebe

et al. 2020

Polymers

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Silk fibroin in material formats provides robust mechanical properties, and thus is a promising protein for 3D printing inks for a range of applications, including tissue engineering, bioelectronics, and bio-optics. Among the various crosslinking mechanisms, photo-crosslinking is particularly useful for 3D printing with silk fibroin inks due to the rapid kinetics, tunable crosslinking dynamics, light-assisted shape control, and the option to use visible light as a biocompatible processing condition. Multiple photo-crosslinking approaches have been applied to native or chemically modified silk fibroin, including photo-oxidation and free radical methacrylate polymerization. The molecular characteristics of silk fibroin, i.e., conformational polymorphism, provide a unique method for crosslinking and microfabrication via light. The molecular design features of silk fibroin inks and the exploitation of photo-crosslinking mechanisms suggest the exciting potential for meeting many biomedical needs in the future.

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“…In particular, engineering of complexities of living organisms into synthetic gels has opened new avenues toward the construction of next generation functional materials. 196,282,[377][378][379][380][381] (i) Aging…”

Section: Time Programmable Self-regulating Gel To Gel Transitionsmentioning

confidence: 99%