Bioprinted constructs that simulate nerve–bone crosstalk to improve microenvironment for bone repair

Wang, Tianchang; Li, Wentao; Zhang, Yuxin; Xu, Xiang Xi; Qiang, Lei; Miao, Weiqiang; Yue, Xiaokun; Jiao, Xia; Zhou, Xin; Ma, Zhen; Li, Shuai; Ding, Muliang; Zhu, Junfeng; Yang, Chengqing; Wang, Hui; Li, Tao; Sun, Xin; Wang, Jinwu

doi:10.1016/j.bioactmat.2023.02.013

Cited by 19 publications

(14 citation statements)

References 67 publications

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Section: Resultsmentioning

confidence: 99%

“…Nerve fibers are present throughout the entire bone structure, including periosteum, bone marrow, cortical bone, and cancellous bone . With increasing focus on the local microenvironment within bones, research on intraosseous nerves has become a prominent area of study, revealing the regulatory effect of the peripheral nervous system on bone metabolism . Neurotransmitters, neuropeptides, axon guidance factors, and neurotrophic factors are secreted by peripheral nerves and are essential for processes involving bone formation and repair .…”

Section: Resultsmentioning

confidence: 99%

“…48 With increasing focus on the local microenvironment within bones, research on intraosseous nerves has become a prominent area of study, revealing the regulatory effect of the peripheral nervous system on bone metabolism. 48 Neurotransmitters, neuropeptides, axon guidance factors, and neurotrophic factors are secreted by peripheral nerves and are essential for processes involving bone formation and repair. 49 Wu et al utilized tissueengineered bones containing sensory nerve fibers to successfully repair large segmental bone defects.…”

Section: Biocompatibility Of Materialsmentioning

confidence: 99%

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An Antibacterial Bionic Periosteum with Angiogenesis-Neurogenesis Coupling Effect for Bone Regeneration

Zhou,

Liu,

Liu

et al. 2024

ACS Appl. Mater. Interfaces

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The periosteum, rich in neurovascular networks, bone progenitor cells, and stem cells, is vital for bone repair. Current artificial periosteal materials face challenges in mechanical strength, bacterial infection, and promoting osteogenic differentiation and angiogenesis. To address these issues, we adjusted the electrospinning ratio of poly-ε-caprolactone and chitosan and incorporated Zn doping whitlockite with polydopamine coating into a nanofiber membrane. After a series of characterizations, optimal results were achieved with a poly-ε-caprolactone: chitosan ratio of 8:1 and 5% nanoparticle content. In vitro cell experiments and in vivo calvarial defect models, the sustained release of Mg2+ and Ca2+ promoted vascularization and new bone formation, respectively, while the release of Zn2+ was conducive to antibacterial and cooperated with Mg2+ to promote neurovascularization. Consequently, this antibacterial bionic periosteum with an angiogenesis-neurogenesis coupling effect demonstrates a promising potential for bone repair applications.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Biocompatibility Of Materialsmentioning

confidence: 99%

See 1 more Smart Citation

An Antibacterial Bionic Periosteum with Angiogenesis-Neurogenesis Coupling Effect for Bone Regeneration

Zhou,

Liu,

Liu

et al. 2024

ACS Appl. Mater. Interfaces

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“…Bone marrow mesenchymal stem cells (BMSCs) are a type of self-renewing and expandable stem cell with multidirectional differentiative potential and paracrine function and thus were widely used in different wound treatment. − The paracrine functions of BMSCs are responsible for improving wound healing, including promoting epidermal cell growth, angiogenesis, collagen deposition, suppressing inflammatory response, and closing wounds (Figure A) . Therefore, the paracrine levels of several relevant factors were measured, namely, TNF-α, IL-1β, CD31, VEGF, TGF-β1, and bFGF.…”

Section: Resultsmentioning

confidence: 99%

Malate-Based Biodegradable Scaffolds Activate Cellular Energetic Metabolism for Accelerated Wound Healing

Wu,

Zhao,

Tao

et al. 2023

ACS Appl. Mater. Interfaces

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The latest advancements in cellular bioenergetics have revealed the potential of transferring chemical energy to biological energy for therapeutic applications. Despite efforts, a three-dimensional (3D) scaffold that can induce long-term bioenergetic effects and facilitate tissue regeneration remains a big challenge. Herein, the cellular energetic metabolism promotion ability of l-malate, an important intermediate of the tricarboxylic acid (TCA) cycle, was proved, and a series of bioenergetic porous scaffolds were fabricated by synthesizing poly(diol l-malate) (PDoM) prepolymers via a facial one-pot polycondensation of l-malic acid and aliphatic diols, followed by scaffold fabrication and thermal-cross-linking. The degradation products of the developed PDoM scaffolds can regulate the metabolic microenvironment by entering mitochondria and participating in the TCA cycle to elevate intracellular adenosine triphosphate (ATP) levels, thus promoting the cellular biosynthesis, including the production of collagen type I (Col1a1), fibronectin 1 (Fn1), and actin alpha 2 (Acta2/α-Sma). The porous PDoM scaffold was demonstrated to support the growth of the cocultured mesenchymal stem cells (MSCs) and promote their secretion of bioactive molecules [such as vascular endothelial growth factor (VEGF), transforming growth factor-β1 (TGF-β1), and basic fibroblast growth factor (bFGF)], and this stem cells-laden scaffold architecture was proved to accelerate wound healing in a critical full-thickness skin defect model on rats.

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“…[1][2][3][4] While vascularized bone scaffolds have demonstrated efficacy in treating bone defects, the precise role of the nervous system in bone regeneration remains incompletely understood. 5,6 Recent investigations have, however, revealed the advantageous impact of sympathetic nervous system (SNS) dysfunction or loss in compound mutant mice on bone mass gain. [7][8][9] Emerging research indicates that bone defects can activate the SNS, prompting an excessive release of catecholamines (CAs).…”

Section: Introductionmentioning

confidence: 99%

3D printing of customized bioceramics for promoting bone tissue regeneration by regulating sympathetic nerve behavior

Su,

Guo,

Gui

et al. 2024

J. Mater. Chem. B

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Bioprinted constructs that simulate nerve–bone crosstalk to improve microenvironment for bone repair

Cited by 19 publications

References 67 publications

An Antibacterial Bionic Periosteum with Angiogenesis-Neurogenesis Coupling Effect for Bone Regeneration

An Antibacterial Bionic Periosteum with Angiogenesis-Neurogenesis Coupling Effect for Bone Regeneration

Malate-Based Biodegradable Scaffolds Activate Cellular Energetic Metabolism for Accelerated Wound Healing

3D printing of customized bioceramics for promoting bone tissue regeneration by regulating sympathetic nerve behavior

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