Bioprinting an Artificial Pancreas for Type 1 Diabetes

Kim, Juewan; Kang, Kyung‐Won; Drogemuller, Chris; Wallace, Gordon G.; Coates, P. Toby

doi:10.1007/s11892-019-1166-x

Cited by 32 publications

(20 citation statements)

References 129 publications

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“…Significant attention has been given to tissue engineering of the digestive system; other reviews have focused on bioprinting strategies for this organ system, so we present only enough background here to demonstrate the use for coaxial bioprinting in these tissues [ [106] , [107] , [108] , [109] ]. Applications include pancreatic islet culture for diabetes treatment [ 110 ] and intestinal engineering [ 44 , 111 ].…”

Section: Applications Of Coaxial Printingmentioning

confidence: 99%

Engineering of tissue constructs using coaxial bioprinting

Kjar

McFarland

Mecham

et al. 2021

Bioactive Materials

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Bioprinting is a rapidly developing technology for the precise design and manufacture of tissues in various biological systems or organs. Coaxial extrusion bioprinting, an emergent branch, has demonstrated a strong potential to enhance bioprinting's engineering versatility. Coaxial bioprinting assists in the fabrication of complex tissue constructs, by enabling concentric deposition of biomaterials. The fabricated tissue constructs started with simple, tubular vasculature but have been substantially developed to integrate complex cell composition and self-assembly, ECM patterning, controlled release, and multi-material gradient profiles. This review article begins with a brief overview of coaxial printing history, followed by an introduction of crucial engineering components. Afterward, we review the recent progress and untapped potential in each specific organ or biological system, and demonstrate how coaxial bioprinting facilitates the creation of tissue constructs. Ultimately, we conclude that this growing technology will contribute significantly to capabilities in the fields of in vitro modeling, pharmaceutical development, and clinical regenerative medicine.

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Section: Applications Of Coaxial Printingmentioning

confidence: 99%

Engineering of tissue constructs using coaxial bioprinting

Kjar

McFarland

Mecham

et al. 2021

Bioactive Materials

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“…Using bioprinting technology, scientists can design artificial pancreatic tissues with vascular structures. However, this emerging technology is still in its initial stages and requires further researches (Juewan Kim et al, 2019b ).…”

Section: Clinical Trials Of Islet Encapsulation and Commercialized Productsmentioning

confidence: 99%

An Overview of Engineered Hydrogel-Based Biomaterials for Improved β-Cell Survival and Insulin Secretion

Ghasemi

Akbari

Imani

2021

Front. Bioeng. Biotechnol.

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Islet transplantation provides a promising strategy in treating type 1 diabetes as an autoimmune disease, in which damaged β-cells are replaced with new islets in a minimally invasive procedure. Although islet transplantation avoids the complications associated with whole pancreas transplantations, its clinical applications maintain significant drawbacks, including long-term immunosuppression, a lack of compatible donors, and blood-mediated inflammatory responses. Biomaterial-assisted islet transplantation is an emerging technology that embeds desired cells into biomaterials, which are then directly transplanted into the patient, overcoming the aforementioned challenges. Among various biomaterials, hydrogels are the preferred biomaterial of choice in these transplants due to their ECM-like structure and tunable properties. This review aims to present a comprehensive overview of hydrogel-based biomaterials that are engineered for encapsulation of insulin-secreting cells, focusing on new hydrogel design and modification strategies to improve β-cell viability, decrease inflammatory responses, and enhance insulin secretion. We will discuss the current status of clinical studies using therapeutic bioengineering hydrogels in insulin release and prospective approaches.

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“…In vitro 3D models have been developed to investigate the in vivo tumor biology, microenvironment and growth conditions of pancreatic cancer cells and to identify new therapeutic approaches for diabetes [73,74]. Diabetes is a major health concern worldwide with a significant burden in terms of clinical and socioeconomic impact [75]. Its prevalence is increasing worldwide, with an estimate of approximately 1 in 300 by 18 years of age in the United States [76].…”

Section: Introductionmentioning

confidence: 99%

Bioprinting Technology in Skin, Heart, Pancreas and Cartilage Tissues: Progress and Challenges in Clinical Practice

Piazza

Pandolfi

Cacciotti

et al. 2021

IJERPH

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Bioprinting is an emerging additive manufacturing technique which shows an outstanding potential for shaping customized functional substitutes for tissue engineering. Its introduction into the clinical space in order to replace injured organs could ideally overcome the limitations faced with allografts. Presently, even though there have been years of prolific research in the field, there is a wide gap to bridge in order to bring bioprinting from “bench to bedside”. This is due to the fact that bioprinted designs have not yet reached the complexity required for clinical use, nor have clear GMP (good manufacturing practices) rules or precise regulatory guidelines been established. This review provides an overview of some of the most recent and remarkable achievements for skin, heart, pancreas and cartilage bioprinting breakthroughs while highlighting the critical shortcomings for each tissue type which is keeping this technique from becoming widespread reality.

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Bioprinting an Artificial Pancreas for Type 1 Diabetes

Cited by 32 publications

References 129 publications

Engineering of tissue constructs using coaxial bioprinting

Engineering of tissue constructs using coaxial bioprinting

An Overview of Engineered Hydrogel-Based Biomaterials for Improved β-Cell Survival and Insulin Secretion

Bioprinting Technology in Skin, Heart, Pancreas and Cartilage Tissues: Progress and Challenges in Clinical Practice

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