Bioprinting for cancer research

Knowlton, Stephanie; Önal, Sevgi; Yu, Chu Hsiang; Zhao, Jean J.; Tasoğlu, Savaş

doi:10.1016/j.tibtech.2015.06.007

Cited by 338 publications

(251 citation statements)

References 84 publications

Supporting

Mentioning

247

Contrasting

Unclassified

Order By: Relevance

“…High-throughput pharmacological study [36,78] 3D bioprinting Primary feline H1 cardiomyocytes First rhythmic beating of 3D printed structure [93][94][95] Lung Microfabrication Epithelial cells Use of porous membrane to mimic lung functions [31,37] 3D bioprinting A549 cells and EA hy926 cells World's first 3D bioprinted lung tissue [101] Bone 3D bioprinting BMSCs High viability in microextrusion-based bioprinting [108,109,158,159] Cancer Self-assembled Intestinal stem cells Discovery of LGR5+ intestinal stem cells [52,62] Microfabrication Breast cancer cells Perfusable human microvascularized bone-mimicking (BMi) microenvironment [81,168] 3D bioprinting OVCAR-5 and MRC-5 cells Insight into complex cell-cell communication in 3D [113][114][115][116][117] Multi Self-assembled Liver, gut, vessel cells High throughput hanging drop [30,[49][50][51][52] Microfabrication Liver, heart, and vessel cells Automated control of perfusion [11,19,27,32] 3D bioprinting NPC and HCT-116 cells Multiorgan bioprinted model [30,122] a)…”

Section: Engineering Technologiesmentioning

confidence: 99%

“…During and after deposition of the 3D scaffold the hydrogel is gelled by thermal-, photo-, or chemical-based approaches. [82,94,113,121,138] The use of toxic materials and high energies requires special care to leave the cells viable and intact. After printing, the tissue/organ construct is matured, either by seeding of cells onto the artificial scaffold or cultivation of cell-laden scaffolds, until proper function can be assessed.…”

Section: D Bioprinted Organ Modelsmentioning

confidence: 99%

“…Bioprinted models can mimic the tumor microenvironment, providing a platform to further understand cancer pathology, screen anticancer drugs, and assess cancer treatment. [113] Demirci and co-workers bioprinted tumor tissue models for in vitro assays, using OVCAR-5 ovarian cancer cells and MRC-5 fibroblasts jetted using a dual-ejector system focusing on the same point. [114] These two cell types were bioprinted on Matrigel to generate multicellular acini in a high throughput and reproducible manner with a spatially mediated microenvironment, controlled cell density and biologically relevant cell-cell distances.…”

Section: Bioprinted Cancer Modelsmentioning

confidence: 99%

See 2 more Smart Citations

3D Miniaturization of Human Organs for Drug Discovery

Park

Wetzel

Dréau

et al. 2017

Adv Healthcare Materials

View full text Add to dashboard Cite

“Engineered human organs” hold promises for predicting the effectiveness and accuracy of drug responses while reducing cost, time, and failure rates in clinical trials. Multiorgan human models utilize many aspects of currently available technologies including self‐organized spherical 3D human organoids, microfabricated 3D human organ chips, and 3D bioprinted human organ constructs to mimic key structural and functional properties of human organs. They enable precise control of multicellular activities, extracellular matrix (ECM) compositions, spatial distributions of cells, architectural organizations of ECM, and environmental cues. Thus, engineered human organs can provide the microstructures and biological functions of target organs and advantageously substitute multiscaled drug‐testing platforms including the current in vitro molecular assays, cell platforms, and in vivo models. This review provides an overview of advanced innovative designs based on the three main technologies used for organ construction leading to single and multiorgan systems useable for drug development. Current technological challenges and future perspectives are also discussed.

show abstract

Section: Engineering Technologiesmentioning

confidence: 99%

Section: D Bioprinted Organ Modelsmentioning

confidence: 99%

Section: Bioprinted Cancer Modelsmentioning

confidence: 99%

See 1 more Smart Citation

3D Miniaturization of Human Organs for Drug Discovery

Park

Wetzel

Dréau

et al. 2017

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…Although inkjet 3D cell printing has Figure 1. Basic techniques of 3D cell printing, (a) laser-assisted 3D cell printing techniques with and without an absorbing layer, [17,22] (b) thermal, piezoelectric, and acoustic inkjet 3D cell printing systems, [22,28] and (c) microextrusion 3D cell printing systems and products [14,35] . unsolved issues, it is expected to be a v ersatile tool in broad tissue engineering application [22,28] .…”

Section: Inkjet 3d Cell Printing Techniquementioning

confidence: 99%

Recent cell printing systems for tissue engineering

Lee¹,

Koo²,

Yeo³

et al. 2017

ijb

View full text Add to dashboard Cite

Three-dimensional (3D) printing in tissue engineering has been studied for the bio mimicry of the structures of human tissues and organs. Now it is being applied to 3D cell printing, which can position cells and biomaterials, such as growth factors, at desired positions in the 3D space. However, there are some challenges of 3D cell printing, such as cell damage during the printing process and the inability to produce a porous 3D shape owing to the embedding of cells in the hydrogel-based printing ink, which should be biocompatible, biodegradable, and non-toxic, etc. Therefore, researchers have been studying ways to balance or enhance the post-print cell viability and the print-ability of 3D cell printing technologies by accommodating several mechanical, electrical, and chemical based systems. In this mini-review, several common 3D cell printing methods and their modified applications are introduced for overcoming deficiencies of the cell printing process.

show abstract

“…Another type of tissue for which bioprinting is used to create a better in vitro model is cancerous tissue [48]. Current two-and three-dimensional models present limitations as the complexity of tumours are not replicated and the tissues do not possess vascular networks [49].…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Current developments in 3D bioprinting for tissue engineering

Cornelissen

Faulkner-Jones

Shu

2017

Current Opinion in Biomedical Engineering

View full text Add to dashboard Cite

This version is available at https://strathprints.strath.ac.uk/61660/ Strathprints is designed to allow users to access the research output of the University of Strathclyde. Unless otherwise explicitly stated on the manuscript, Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Please check the manuscript for details of any other licences that may have been applied. You may not engage in further distribution of the material for any profitmaking activities or any commercial gain. You may freely distribute both the url (https://strathprints.strath.ac.uk/) and the content of this paper for research or private study, educational, or not-for-profit purposes without prior permission or charge.Any correspondence concerning this service should be sent to the This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPTCurrent developments in 3D bioprinting for tissue engineering AbstractThe field of 3-dimensional (3D) bioprinting have enjoyed rapid development in the past few years for the applications in tissue engineering and regenerative medicine. In this review, we summarize the most updated developments in 3D bioprinting for the applications in the tissue engineering with a focus on the printable biomaterials used as bioinks. These developments include 1) novel printing regimes have been enabled by the use of fugitive inks for the creation of intricate structures e.g. vascularized tissue constructs; 2) mechanical strength of printed constructs can be enhanced by co-printing soft and hard biomaterials; 3) bioprinted in-vitro models for drug testing applications are closer to reality. We conclude that the research and application of new bioinks will remain the key highlights of the future developments in 3D bioprinting for tissue engineering.

show abstract

Bioprinting for cancer research

Cited by 338 publications

References 84 publications

3D Miniaturization of Human Organs for Drug Discovery

3D Miniaturization of Human Organs for Drug Discovery

Recent cell printing systems for tissue engineering

Current developments in 3D bioprinting for tissue engineering

Contact Info

Product

Resources

About