Bioprinting of 3D in vitro skeletal muscle models: A review

Zhuang, Pei; An, Jia; Chua, Chee Kai; Tan, Lay Poh

doi:10.1016/j.matdes.2020.108794

Cited by 68 publications

(66 citation statements)

References 233 publications

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“…The utilization of biomaterials for the 3D printing of complex structures such as muscles, skin, bones, and cartilage is known as bioprinting [34]. This technology involves the precise arrangement of bio-inks (different cell types, biomaterials, and growth factors) within a single structural framework [35].…”

Section: Biomaterials-based 3dp: Bioprintingmentioning

confidence: 99%

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Potential Development of Sustainable 3D-Printed Meat Analogues: A Review

Ramachandraiah

2021

Sustainability

114

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To mitigate the threat of climate change driven by livestock meat production, a multifaceted approach that incorporates dietary changes, innovative product development, advances in technologies, and reductions in food wastes/losses is proposed. The emerging technology of 3D printing (3DP) has been recognized for its unprecedented capacity to fabricate food products with intricate structures and reduced material cost and energy. For sustainable 3DP of meat substitutes, the possible materials discussed are derived from in vitro cell culture, meat byproducts/waste, insects, and plants. These material-based approaches are analyzed from their potential environmental effects, technological viability, and consumer acceptance standpoints. Although skeletal muscles and skin are bioprinted for medical applications, they could be utilized as meat without the additional printing of vascular networks. The impediments to bioprinting of meat are lack of food-safe substrates/materials, cost-effectiveness, and scalability. The sustainability of bioprinting could be enhanced by the utilization of generic/universal components or scaffolds and optimization of cell sourcing and fabrication logistics. Despite the availability of several plants and their byproducts and some start-up ventures attempting to fabricate food products, 3D printing of meat analogues remains a challenge. From various insects, powders, proteins (soluble/insoluble), lipids, and fibers are produced, which—in different combinations and at optimal concentrations—can potentially result in superior meat substitutes. Valuable materials derived from meat byproducts/wastes using low energy methods could reduce waste production and offset some greenhouse gas (GHG) emissions. Apart from printer innovations (speed, precision, and productivity), rational structure of supply chain and optimization of material flow and logistic costs can improve the sustainability of 3D printing. Irrespective of the materials used, perception-related challenges exist for 3D-printed food products. Consumer acceptance could be a significant challenge that could hinder the success of 3D-printed meat analogs.

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Section: Biomaterials-based 3dp: Bioprintingmentioning

confidence: 99%

“…Notes, Adapted from[34]. dECM, decellularized extracellular matrix; PCL, polycaprolactone; CMCMA, carboxymethyl cellulose-methacrylate; MA, alginate-methacrylate; HA, hyaluronic acid; C2C12, myoblast cell line; and hMPCs, human primary muscle progenitor cells.…”

mentioning

confidence: 99%

Potential Development of Sustainable 3D-Printed Meat Analogues: A Review

Ramachandraiah

2021

Sustainability

114

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“…Skeletal muscles are essentially made of myoblasts whereas tendons mainly consist of collagen ECM and a few embedded tenocytes [ 152 ]. Various biomaterials have been utilized by different research groups for the development of such tissue [ 97 , 153 ]. Renal tubular tissue of the kidney has also been studied for construction using bioprinting [ 4 , 154 ].…”

Section: Applications Of 3d Bioprinting In Tissue Engineering and Biomedicinementioning

confidence: 99%

The promising rise of bioprinting in revolutionalizing medical science: Advances and possibilities

Jamee

Araf

Naser

et al. 2021

Regenerative Therapy

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Bioprinting is a relatively new yet evolving technique predominantly used in regenerative medicine and tissue engineering. 3D bioprinting techniques combine the advantages of creating Extracellular Matrix (ECM)like environments for cells and computer-aided tailoring of predetermined tissue shapes and structures. The essential application of bioprinting is for the regeneration or restoration of damaged and injured tissues by producing implantable tissues and organs. The capability of bioprinting is yet to be fully scrutinized in sectors like the patient-specific spatial distribution of cells, bio-robotics, etc. In this review, currently developed experimental systems and strategies for the bioprinting of different types of tissues as well as for drug delivery and cancer research are explored for potential applications. This review also digs into the most recent opportunities and future possibilities for the efficient implementation of bioprinting to restructure medical and technological practices.

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“…Todo o trabalho e organização desse tecido altamente especializado e sofisticado é feita em conjunto, como uma unidade (Berne e Levy 2010). Resumidamente, a composição anatômica de cada músculo envolve a junção de fibras musculares, originárias da fusão de muitas células musculares embrionárias, a estruturas importantes, como os nervos e os vasos sanguíneos, envoltas por tecido conectivo, que contribuem de maneira específica na formação desse tecido, mantendo a produção eficiente de energia e homeostase celular (Smoak e Mikos 2020;Zhuang et al 2020).…”

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Bases metabólicas e funcionais do sistema neuromuscular esquelético: da formação a contração

Sena

Gomes

2021

Multi

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Skeletal muscle is a type of highly plastic striated muscle tissue, which can adapt to physiological changes from neural, hormonal or external stimuli. All the work and organization of this highly specialized and sophisticated fabric is done together, as a unit. With the advancement of technologies, the development of the skeletal neuromuscular system is increasingly studied. Thus, the purpose of the present study was to explore the skeletal neuromuscular system on its structural, physiological properties and their respective functions, through a mini literature review. This study is a literature review on the skeletal neuromuscular system and all the mechanisms involved for its functioning, constituting an informative textual construction without establishing systematic criteria on the part of the author. The skeletal neuromuscular system represents about 40 to 45% on average of the total body mass in the adult individual and stores around 50 to 75% of all proteins that the individual has. Composed of vessels, nerves and muscle fibers, skeletal muscle performs vital functions, from the simplest to the most complex, demonstrating its importance for survival and preservation of life.

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Bioprinting of 3D in vitro skeletal muscle models: A review

Cited by 68 publications

References 233 publications

Potential Development of Sustainable 3D-Printed Meat Analogues: A Review

Potential Development of Sustainable 3D-Printed Meat Analogues: A Review

The promising rise of bioprinting in revolutionalizing medical science: Advances and possibilities

Bases metabólicas e funcionais do sistema neuromuscular esquelético: da formação a contração

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