Bioprinting of skin constructs for wound healing

He, Peng; Zhao, Junning; Zhang, Jiumeng; Li, Bo; Gou, Zhiyuan; Gou, Maling; Li, Xiaolu

doi:10.1186/s41038-017-0104-x

Cited by 189 publications

(148 citation statements)

References 74 publications

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“…Wound healing follows a dynamic and orderly process, and according to the nature of wound healing, it can be classified into acute wound and chronic wound . Acute wounds, also known as normal wounds, are usually caused by mechanical, burn, or chemical injuries .…”

Section: Causes and Healing Of Woundsmentioning

confidence: 99%

Advances and Impact of Antioxidant Hydrogel in Chronic Wound Healing

Han

et al. 2020

Adv Healthcare Materials

491

305

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The accelerating and thorough treatment of chronic wounds still represents a major unmet medical need owing to the complex symptoms resulting from metabolic disorder of the wound microenvironment. Although numerous strategies and bioactive hydrogels are developed, an effective and widely used method of chronic wound treatment remains a bottleneck. With the aim to accelerate chronic wound healing, many hydrogel dressings with antioxidant functions have emerged and are proven to accelerate wound healing, especially for chronic wound repair. The new strategy in chronic wound treatment brought by antioxidant hydrogels is of great significance to human health. Here, the application of antioxidant hydrogels in the repair of chronic wounds is discussed systematically, aiming to provide an important theoretical reference for the further breakthrough of chronic wound healing.

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Section: Causes and Healing Of Woundsmentioning

confidence: 99%

Advances and Impact of Antioxidant Hydrogel in Chronic Wound Healing

Han

et al. 2020

Adv Healthcare Materials

491

305

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“…Cell therapies for skin wounds are developing as treatments, demonstrating accelerated wound healing compared to biological skin equivalents. While fast wound coverage has been achieved through delivery of cell suspensions through cell spraying devices, these methods lack the ability to spatially pattern cells for the generation of complex skin structures . Through the design of this in situ printing system, the group aimed to create a portable platform that could be easily transported and sterilized to then identify a variety of wound topologies and deliver multiple cell types in precise, patient‐specific geometries .…”

Section: Advanced 3d Printing Technologiesmentioning

confidence: 99%

Recent Advances in Enabling Technologies in 3D Printing for Precision Medicine

2019

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Advances in areas such as data analytics, genomics, and imaging have revealed individual patient complexities and exposed the inherent limitations of generic therapies for patient treatment. These observations have also fueled the development of precision medicine approaches, where therapies are tailored for the individual rather than the broad patient population. 3D printing is a field that intersects with precision medicine through the design of precision implants with patient‐directed shapes, structures, and materials or for the development of patient‐specific in vitro models that can be used for screening precision therapeutics. Toward their success, advances in 3D printing and biofabrication technologies are needed with enhanced resolution, complexity, reproducibility, and speed and that encompass a broad range of cells and materials. The overall goal of this progress report is to highlight recent advances in 3D printing technologies that are helping to enable advances important in precision medicine.

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“…Also, with respect to cell selection, keratinocytes are the primary cell types used for bioprinting of skin cells [34]. The advantages to using bioprinting of skin constructs includes greater accuracy in placement of cells and extracellular matrix as well as having the potential of imbedding vasculature in the skin construct as bioprinting of vasculature is also possible [54]. Skin constructs made through bioprinting are also considered to have great plasticity [54].…”

Section: Bioprinting Of Skin Constructsmentioning

confidence: 99%

2D vs. 3D Cell Culture Models for In Vitro Topical (Dermatological) Medication Testing

Teimouri¹,

Yeung²,

Agu³

2019

Cell Culture

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Due to ethical concerns regarding animal testing, alternative methods have been in development to test the efficacy and safety of pharmaceutical products and medications, specifically topical (dermatological) medications. Two-dimensional (2D) and three-dimensional (3D) skin cell cultures are examples of in vitro methods used as an alternative to animal testing. The first skin cells cultured were keratinocytes, a type of cell predominantly in the epidermal layer of the skin. However, with differences in skin characteristics and pathophysiology of different skin conditions, various skin cell cultures and models to better mimic these differences have been developed. These cell cultures include not only keratinocytes but also other skin cell types, such as fibroblasts, which are predominantly in the dermal layer of the skin, and certain immune cells and even melanocytes. To have a better understanding of the type of cell cultures used for testing dermatological products, this chapter aims to outline the differences between 2D and 3D skin cell cultures while considering the advantages and disadvantages of each culture. Different types of cell culture models used for wound healing and for inflammatory skin conditions such as psoriasis will also be discussed.

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Bioprinting of skin constructs for wound healing

Cited by 189 publications

References 74 publications

Advances and Impact of Antioxidant Hydrogel in Chronic Wound Healing

Advances and Impact of Antioxidant Hydrogel in Chronic Wound Healing

Recent Advances in Enabling Technologies in 3D Printing for Precision Medicine

2D vs. 3D Cell Culture Models for In Vitro Topical (Dermatological) Medication Testing

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