Bioprocess Simulation and Economics

Petrides, Demetri; Carmichael, Doug; Siletti, Charles; Koulouris, Alexandros

doi:10.1007/978-3-030-16230-6_9

Cited by 14 publications

(14 citation statements)

References 5 publications

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“…It consists of two main activities, process synthesis and process analysis. The synthesis is the selection and arrangement of a set of unit operations capable of producing the desired product at an acceptable cost and quality [73]. Process analysis is the evaluation and comparison of different process synthesis solutions.…”

Section: Bioprocess Designmentioning

confidence: 99%

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Emerging strategies for the development of food industries

et al. 2019

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Undoubtedly, the food industry is undergoing a dynamic process of transformation in its continual development in order to meet the requirements and solve the great problems represented by a constantly growing global population and food claimant in both quantity and quality. In this sense, it is necessary to evaluate the technological trends and advances that will change the landscape of the food processing industry, highlighting the latest requirements for equipment functionality. In particular, it is crucial to evaluate the influence of sustainable green biotechnology-based technologies to consolidate the food industry of the future, today, and it must be done by analyzing the mega-consumption trends that shape the future of industry, which range from local sourcing to on-the-go food, to an increase in organic foods and clean labels (understanding ingredients on food labels). While these things may seem alien to food manufacturing, they have a considerable influence on the way products are manufactured. This paper reviews in detail the conditions of the food industry, and particularly analyzes the application of emerging technologies in food preservation, extraction of bioactive compounds, bioengineering tools and other biobased strategies for the development of the food industry.

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Section: Bioprocess Designmentioning

confidence: 99%

“…Process analysis is the evaluation and comparison of different process synthesis solutions. The process is divided into two phases: upstream and downstream processing accounts for a large proportion of the production costs [72,73].…”

Section: Bioprocess Designmentioning

confidence: 99%

Emerging strategies for the development of food industries

et al. 2019

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“…For preliminary cost estimates, the entire fixed capital investment was usually depreciated linearly over a 10-year period. The annual equipment maintenance cost was normally estimated as a 10% of the equipment's purchase cost (Petrides, 2015). Insurance value for bio-processing facilities was generally in the range of 0.5-1% of direct fixed capital (DFC).…”

Section: Biodiesel Production Costmentioning

confidence: 99%

Economic assessment of biodiesel production from wastewater sludge

Chen

Tyagi

et al. 2018

Bioresource Technology

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Currently, there are mainly two pathways of the biodiesel production from wastewater sludge including 1) directly extracting the lipid in sludge and then converting the lipid to biodiesel through trans-esterification, and 2) employing sludge as medium to cultivate oleaginous microorganism to accumulate lipid and then transferring the lipid to biodiesel. So far, the study was still in research stage and its cost feasibility was not yet investigated. In this study, biodiesel production from wastewater sludge was designed and the cost was estimated with SuperPro Designer. With consideration of converting the lipid in raw sludge to biodiesel, the unit production cost was 0.67 US $/kg biodiesel (0.59 US $/L biodiesel). When the sludge was used as medium to grow oleaginous microorganism to accumulate lipid for producing biodiesel, the unit production cost was 1.08 US $/kg biodiesel (0.94 US $/L biodiesel). The study showed that sludge has great potential in biodiesel production.

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“…Technoeconomic analysis is a useful tool for exploring the feasibility of industrial processes. The analysis entails a computational simulation of the process, which encompasses the mass and energy balances around a series of unit operations and which provides an accounting of the potential costs and revenues associated with the entire processing facility (Petrides, 2015). Although technoeconomic analysis has been routinely utilized to perform feasibility studies for prospective biofuel, biochemical, food, and pharmaceutical manufacturing processes (Alshekhli et al, 2011;Demichelis et al, 2018;Lam et al, 2014;Mupondwa et al, 2015;Zabot et al, 2018), scant literature is available regarding its application to encapsulation processes.…”

Section: Introductionmentioning

confidence: 99%

Comparative Technoeconomic Process Analysis of Industrial-Scale Microencapsulation of Bioactives in Cross-Linked Alginate

Strobel

Knowles

Nitin

et al. 2019

Preprint

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<div>The food, chemical, and biotechnology industries offer many potential applications for calcium alginate microencapsulation, but this technique is largely confined to the laboratory bench due to scalability challenges. Scaling up the traditional external gelation method requires several costly unit operations. Alternatively, a consolidated process accomplishes alginate cross-linking in situ during spray-drying to form cross-linked alginate microcapsules (‘the CLAMs process’). This work examined the process economics of these two microencapsulation processes through technoeconomic analysis. Parallel batch process models were constructed in SuperPro Designer, initially for encapsulating emulsified fish oil. At all production scales examined, the capital investment and annual operating cost were lower for the CLAMs process. Modifying the external gelation process marginally improved the process economics, but costs remained elevated. The CLAMs process’ economic advantage stemmed from reducing the number of unit procedures, which lowered the equipment purchase cost and the dependent components of capital investment and annual operating cost. Upon modifying the models for microencapsulating hydrophilic cargo (e.g. enzymes, vitamins, microbial concentrates), the CLAMs process remained favorable at all cargo material costs and cargo loadings examined. This work demonstrates the utility of technoeconomic analysis for evaluating microencapsulation processes and may justify applying the CLAMs process at the industrial scale. </div>

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Bioprocess Simulation and Economics

Cited by 14 publications

References 5 publications

Emerging strategies for the development of food industries

Emerging strategies for the development of food industries

Economic assessment of biodiesel production from wastewater sludge

Comparative Technoeconomic Process Analysis of Industrial-Scale Microencapsulation of Bioactives in Cross-Linked Alginate

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