Bioprospecting fungal-derived value-added bioproducts for sustainable pharmaceutical applications

Afifa, .; Hussain, N.; Baqar, Zulqarnain; Mumtaz, Mehvish; El-Sappah, Ahmed H.; Show, Pau Loke; Iqbal, Hafiz M.N.; Varjani, Sunita; Bilal, Muhammad

doi:10.1016/j.scp.2022.100755

Cited by 10 publications

(2 citation statements)

References 180 publications

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“…S4). Plant phytohormones have been shown to play indispensable roles in disease response [108], [109]. The jasmonate (JA)-mediated defence responses of Capsicum annuum suggest the molecular interaction of JA and salicylic acid (SA) in de ning the resistance mechanism against Phytophthora blight [110].…”

Section: Differential Expression Pro Les Ofmentioning

confidence: 99%

Dual RNA-seq analysis unveils the molecular interactions between coconut (Cocos nucifera L.) and Phytophthora palmivora, the bud rot pathogen

P.,

K.,

Jangam

et al. 2024

Preprint

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Background The bud rot pathogen Phytophthora palmivora poses a significant threat to coconut production worldwide. Effective management strategies against this devastating pathogen are lacking due to the absence of resistant cultivars and limited knowledge about its pathogenicity mechanisms. To address this, we conducted dual RNA-seq analyses at three time points (12, 24, and 36 hours post-infection) during the initial progression of the disease, using a standardized in vitro assay. This study aimed to identify transcriptional regulation following infection and decipher the system-level host response to P. palmivora. Results Differential gene expression (DGE) analysis between control and infected samples revealed extensive modulation of stress-responsive genes in coconut. In contrast, P. palmivora showed differential expression of genes encoding effector and carbohydrate-active enzymes (CAZy). Pathway enrichment analysis highlighted the up-regulation of genes associated with plant-pathogen interaction pathway and plant hormone signal transduction in coconut. To validate our findings, we selected ten candidate differentially expressed genes (DEGs) from both coconut and P. palmivora for quantification using qRT-PCR at the three time points. The expression trends observed in qRT-PCR confirmed the reliability of the dual RNA-seq data, further supporting the comprehensive outlook on the global response of coconut to P. palmivora infection. Conclusions This study highlights the significant modulation of stress-responsive genes in coconut and differential expression of effector and carbohydrate-active enzyme genes in P. palmivora during bud rot infection. The findings provide valuable insights into the molecular interactions and transcriptional regulation underlying the coconut-P. palmivora pathosystem, aiding in the development of effective management strategies against this devastating pathogen.

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Section: Differential Expression Pro Les Ofmentioning

confidence: 99%

Dual RNA-seq analysis unveils the molecular interactions between coconut (Cocos nucifera L.) and Phytophthora palmivora, the bud rot pathogen

P.,

K.,

Jangam

et al. 2024

Preprint

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“…The authors observed that T. atroviride-inoculated rice plants had increased tiller number, biomass, and yield compared to non-inoculated plants. In another study, T. harzianum was found to produce CKs in vitro, and the authors observed that T. harzianum-inoculated tomato plants had increased shoot growth, leaf area, and dry weight compared to noninoculated plants (Hussain et al, 2022). Trichoderma can also produce compounds that promote stress tolerance and enhance plant growth under adverse environmental conditions.…”

Section: Trichoderma For Plant Growth Regulationmentioning

confidence: 99%

Trichoderma: Multitalented Biocontrol Agent

2023

IJAB

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Trichoderma is a genus of fungi that has been widely studied for its ability to act as a biocontrol agent against plant pathogens. This review summarizes recent research on the mechanisms of action of Trichoderma as a biocontrol agent and its potential for use in sustainable agriculture. Trichoderma can control plant pathogens through various mechanisms, including competition for nutrients and space, mycoparasitism, and induction of systemic resistance in the host plant. The effectiveness of Trichoderma as a biocontrol agent depends on various factors, such as the species and strain used, the timing and method of application, and the environmental conditions. In addition to its biocontrol properties, Trichoderma can also promote plant growth and health by improving nutrient uptake and stress tolerance. However, the implementation of Trichoderma as a biocontrol agent in agriculture faces some challenges, such as the lack of standardized methods for production and application, and the need for further research to understand its interactions with other soil microorganisms. Overall, Trichoderma shows great potential as a sustainable alternative to chemical pesticides in agriculture, and further research and development are needed to maximize its efficacy and integration into farming practices.

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Lipase Synthesis Using Palm Oil Mill Effluent for Polycaprolactone Production

Jewaratnam

Thegarathah

2023

Sustainable Material for Biomedical Engineering Application

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Bioprospecting fungal-derived value-added bioproducts for sustainable pharmaceutical applications

Cited by 10 publications

References 180 publications

Dual RNA-seq analysis unveils the molecular interactions between coconut (Cocos nucifera L.) and Phytophthora palmivora, the bud rot pathogen

Dual RNA-seq analysis unveils the molecular interactions between coconut (Cocos nucifera L.) and Phytophthora palmivora, the bud rot pathogen

Trichoderma: Multitalented Biocontrol Agent

Lipase Synthesis Using Palm Oil Mill Effluent for Polycaprolactone Production

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