2005
DOI: 10.1263/jbb.100.235
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Bioreactor design for tissue engineering

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Cited by 279 publications
(184 citation statements)
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“…Ergun proposed empirical expressions to describe the two permeability parameters for packed columns made of grains (Innocentini et al 1999;Nield and Bejan 2006). These expressions are:…”
Section: Porosity and Permeability Constantsmentioning
confidence: 99%
“…Ergun proposed empirical expressions to describe the two permeability parameters for packed columns made of grains (Innocentini et al 1999;Nield and Bejan 2006). These expressions are:…”
Section: Porosity and Permeability Constantsmentioning
confidence: 99%
“…However, it is challenging to examine biomechanical mechanisms in vivo . To investigate cell fate and tissue maturation when external forces are applied and to provide physical growth environments for cells and tissues in vitro bioreactors have been developed, subjecting cells to various types of mechanical forces, such as hydrostatic pressure 23, 24. Hydrostatic pressure is present in the body in various magnitudes and has been shown to be a relevant physical stimulus for load‐bearing bones where osteocytes in the canaliculi lacuna network are exposed to a hydrostatic pressure of around 270 kPa 25, 26.…”
Section: Introductionmentioning
confidence: 99%
“…The overall aim of using a bioreactor is to mimic physiological conditions, including nutrients, oxygen, temperature, pH, carbon dioxide, humidity and mechanical stress. In addition, automated processing reduces the risk of contaminations and increases reproducibility Portner et al, 2005). One of the most important prerequisites for generating tissue-engineered cartilage is the homogeneous distribution of cells in the scaffold.…”
Section: Bioreactorsmentioning
confidence: 99%