“…Closed photobioreactors may be located indoors or outdoors (Sánchez Mirón et al, 1999;Pulz, 2001), but outdoor location is more common because it can make use of free sunlight. Design and operation of the microalgal biomass production systems have been discussed extensively (Terry and Raymond, 1985;Borowitzka, 1996;Pulz and Scheinbenbogen, 1998;Pulz, 2001;Pulz et al, 2001;Sánchez Mirón et al, 1999;Tredici, 1999). Here, we focus exclusively on issues relating with the harvest of the biomass and its downstream processing to recover intracellular metabolites.…”