Bioreducible core-crosslinked hyaluronic acid micelle for targeted cancer therapy

Han, Hwa Seung; Choi, Ki Young; Ko, Hyewon; Jeon, Jueun; Saravanakumar, G.; Suh, Yung Doug; Lee, Sang Soo; Park, Jae Hyung

doi:10.1016/j.jconrel.2014.12.032

Cited by 104 publications

(63 citation statements)

References 27 publications

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“…As shown in Figure 3C, our group also reported a robust core-cross-linked HA micelles (CC-HAM) via a facile method of disulfide bond formation. [7] The CC-HAM showed enhanced in vivo tumor-targetability and therapeutic efficacy, compared to the non-cross-linked HAMs. This is attributed to the improved blood stability of CC-HAM upon systemic administration in vivo.…”

Section: Ha-based Nanoparticles For Small Molecular Drug Deliverymentioning

confidence: 96%

“…The use of cleavable crosslinks, responsive to stimuli such as the low pH and the reductive environment, has surmounted these problems to some extent. [7,71] These cross-linking chemistries are inherently inefficient and hard to quantify the extent of cross-linking experimentally. Hence, there is a need to develop new and efficient cross-linking strategies that can allow us to control efficiently and quantify the extent of cross-linking.…”

Section: Ha-based Nanoparticles For Small Molecular Drug Deliverymentioning

confidence: 99%

“…[6][7][8][9][10][11][12][13][14][15] HA is a naturally occurring polyanionic polysaccharide found in the body, such as extracellular matrix and synovial fluid. It is a linear polymer consisting of a repeating disaccharide unit of D-glucuronic acid and N-acetyl-D-glucosamine.…”

Section: Introductionmentioning

confidence: 99%

“…D. Schematic diagram for preparation of photo-cross-linked HA nanoparticles (c-HANPs) by UV-triggered cross-linking. Adapted with permission from[7,8,71].…”

mentioning

confidence: 99%

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Recent developments in hyaluronic acid-based nanomedicine for targeted cancer treatment

Rao

Yoon

Han

et al. 2015

Expert Opinion on Drug Delivery

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To develop a successful HA-based nanomedicine, it has to be prepared without significant deterioration of intrinsic property of HA. The chemical modification of HA with drugs or hydrophobic moieties may reduce the binding affinity of HA to the receptors. In addition, since the HA-based nanomedicines tend to accumulate in the liver after their systemic administration, new strategies to overcome this issue have to be developed.

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Section: Ha-based Nanoparticles For Small Molecular Drug Deliverymentioning

confidence: 96%

Section: Ha-based Nanoparticles For Small Molecular Drug Deliverymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…D. Schematic diagram for preparation of photo-cross-linked HA nanoparticles (c-HANPs) by UV-triggered cross-linking. Adapted with permission from[7,8,71].…”

mentioning

confidence: 99%

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Recent developments in hyaluronic acid-based nanomedicine for targeted cancer treatment

Rao

Yoon

Han

et al. 2015

Expert Opinion on Drug Delivery

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“…27 DOX-loaded NPs (5 mL) were added to a dialysis bag (MWCO 3,500 Da), which was placed in a container with PBS (100 mL) of different pH levels as corresponding mediums. At designed time points, 1 mL of the corresponding medium from each group was collected for concentration determination and replaced with an equal volume of fresh medium.…”

Section: Drug Release From Dox-loaded Nps In Vitromentioning

confidence: 99%

Stepwise pH-responsive nanoparticles for enhanced cellular uptake and on-demand intracellular release of doxorubicin

Chen¹,

Li²,

Tang³

et al. 2017

IJN

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Physicochemical properties, including particle size, zeta potential, and drug release behavior, affect targeting efficiency, cellular uptake, and antitumor effect of nanocarriers in a formulated drug-delivery system. In this study, a novel stepwise pH-responsive nanodrug delivery system was developed to efficiently deliver and significantly promote the therapeutic effect of doxorubicin (DOX). The system comprised dimethylmaleic acid-chitosan-urocanic acid and elicited stepwise responses to extracellular and intracellular pH. The nanoparticles (NPs), which possessed negative surface charge under physiological conditions and an appropriate nanosize, exhibited advantageous stability during blood circulation and enhanced accumulation in tumor sites via enhanced permeability and retention effect. The tumor cellular uptake of DOX-loaded NPs was significantly promoted by the first-step pH response, wherein surface charge reversion of NPs from negative to positive was triggered by the slightly acidic tumor extracellular environment. After internalization into tumor cells, the second-step pH response in endo/lysosome acidic environment elicited the on-demand intracellular release of DOX from NPs, thereby increasing cytotoxicity against tumor cells. Furthermore, stepwise pH-responsive NPs showed enhanced antiproliferation effect and reduced systemic side effect in vivo. Hence, the stepwise pH-responsive NPs provide a promising strategy for efficient delivery of antitumor agents.

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Marine Polysaccharide‐Based Nanomaterials

Manivasagan

2020

Encyclopedia of Marine Biotechnology

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Bioreducible core-crosslinked hyaluronic acid micelle for targeted cancer therapy

Cited by 104 publications

References 27 publications

Recent developments in hyaluronic acid-based nanomedicine for targeted cancer treatment

Recent developments in hyaluronic acid-based nanomedicine for targeted cancer treatment

Stepwise pH-responsive nanoparticles for enhanced cellular uptake and on-demand intracellular release of doxorubicin

Marine Polysaccharide‐Based Nanomaterials

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