Bioresorbable Collagen Membranes for Guided Bone Regeneration

Tal, Haim; Moses, Ofer; Nemcovsky, Carlos E.

doi:10.5772/34667

Cited by 24 publications

(28 citation statements)

References 67 publications

(79 reference statements)

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“…Other membranes such as BioGides and TutoDent are produced with non-crosslinked type I and III collagens or bovine type I collagen respectively [30]. Despite the effectiveness of the crosslinking of collagen with glutaraldehyde, these membranes showed in vitro [35] and in vivo [13] increase of cytotoxicity that has been attribute to glutaraldehyde release during the degradation of collagen, inhibiting cell proliferation [35]. The process of crosslinking of collagen with glutaraldehyde and the amount of glutaraldehyde used, has been improved to withdraw its cytotoxicity [35].…”

Section: Collagenmentioning

confidence: 97%

Membranes for periodontal tissues regeneration

Babo

Pires

Reis

et al. 2014

Ciência & Tecnologia dos Materiais

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Section: Collagenmentioning

confidence: 97%

Membranes for periodontal tissues regeneration

Babo

Pires

Reis

et al. 2014

Ciência & Tecnologia dos Materiais

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“…The resorbable membrane has the potential to support bone formation only with enough time to function as a barrier over a certain period. 7,8 Many ways are done to improve the stability of the collagen membrane material to make a longer degradation time, thus having sufficient time to function as a barrier. The degradation of collagen membranes caused by collagenase activity produced by matrix metalloproteinases(MMPs).…”

Section: Introductionmentioning

confidence: 99%

The influence of collagen membranes and tetracycline on the PDGF-BB expression and osteoblast amount in bone defects healing: Experimental study in mice

2018

IJCTR

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Introduction: Collagen membranes have been used in Guided Tissue Regeneration and Guided Bone Regeneration methods. Collagen membranes immersed in a tetracycline solution before the application is able to slow down the degradation of the membrane. Tetracycline is an antibiotic that has widely used in periodontal treatment, with an antibacterial effect that inhibits an MMP matrix which giving therapeutic advantages in the regenerative procedures. The objective of the study was to evaluate the effect of collagen and tetracycline membranes on the tissue regeneration by analyzing the PDGF-BB expression and osteoblast cells in the bone healing process. Methods: This study was an experimental study conducted on 48 male Wistar rats, divided into four treatment groups. The P1 group was the group with collagen membrane added with tetracycline; the P2 group was with collagen membrane collagen without tetracycline; the P3 was without any collagen membrane or tetracycline; the P4 group was without membrane but with tetracycline. Animal testing was conducted to see the effect of collagen and tetracycline membranes on wound healing by measuring the PDGF-BB expression, and the number of osteoblasts. Bone defects were made in the mandibular bones of mice, the PDGF-BB expression was analyzed by immunohistochemistry, and the histologic number of osteoblasts was analyzed with HE histological preparations. The examination or measurement of these parameters was performed on the third, seventh, fourteenth, and twenty-first days. All data were collected and analyzed statistically by using the ANOVA and t-test. Results: From the statistical analysis were obtained that the PDGF-BB expression among the treatment groups was p = 0.0003; the number of osteoblasts p = 0.001. The results of the correlation analysis of the PDGF-BB expression with osteoblast number was p = 0.001; r = 0.64. Conclusion: Collagen membrane with tetracycline was able to increase the PDGF-BB expression and the number of osteoblasts in the wound healing process.

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“…Cross‐linking among collagen fibrils has become an important method of slowing collagen membrane resorption times to maintain membrane‐protected spaces critical to successful bone regeneration 4‐9 . A number of cross‐linking agents have been used to modify GBR membranes, including formaldehyde, glutaraldehyde, and the sugar d ‐ribose 4‐6,10‐12 . Although successful in slowing resorption times, a number of studies suggest that cross‐linked membranes may be more prone to premature membrane exposure than non‐cross‐linked membranes 8,13,14 .…”

Section: Introductionmentioning

confidence: 99%

“…[4][5][6][7][8][9] A number of crosslinking agents have been used to modify GBR membranes, including formaldehyde, glutaraldehyde, and the sugar D-ribose. [4][5][6][10][11][12] Although successful in slowing resorption times, a number of studies suggest that cross-linked membranes may be more prone to premature membrane exposure than non-cross-linked membranes. 8,13,14 Although in the majority of cases overlying soft tissue dehiscences will heal, premature membrane exposure may nevertheless compromise new bone formation during GBR procedures.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Premature Membrane Exposure and Early Healing in Guided Bone Regeneration of Peri‐Implant Dehiscence and Fenestration Defects With a Slowly Resorbing Porcine Collagen Ribose Cross‐Linked Membrane: A Consecutive Case Series

Scheyer

McGuire

2015

Clin Adv Periodontics

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Introduction: Guided bone regeneration (GBR) is a well‐known and accepted procedure for effective treatment of oral bony defects that is dependent on sustained barrier membrane function for adequate new bone formation. Cross‐linking between collagen fibrils with various agents has proven to be effective in prolonging membrane integrity and function, both critical to positive bone regenerative outcomes. Overlying mucosal dehiscence with membrane exposure may lead to less than adequate new bone formation. The current case series examines guided bone regenerative outcomes for peri‐implant defects using a ribose cross‐linked porcine collagen membrane that appears to reduce the risk of cross‐linking–associated membrane exposure. Case Series: Seven patients with nine sites having peri‐implant dehiscence and fenestration defects were enrolled in this consecutive case series pilot study. At surgery, the linear range of implant thread exposure was 5 to 10 mm (mean of ≈6.3 mm). After implant insertion, grafting with mineralized allograft, and placement of a ribose cross‐linked collagen membrane, patients were followed for a minimum of 6 months. At 6‐month reentry surgery, all dehiscence and fenestration defects were eliminated with newly regenerated bone covering previously exposed implant threads. No membrane exposure occurred during this study. Conclusions: Successful GBR outcomes may be enhanced by avoiding premature membrane exposure. Although collagen cross‐linking may be associated with increased mucosal dehiscence, the ribose cross‐linked membrane examined in the current study may help promote positive regenerative outcomes by sustained functional and structural integrity and a reduction in membrane exposure incidence.

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Bioresorbable Collagen Membranes for Guided Bone Regeneration

Cited by 24 publications

References 67 publications

Membranes for periodontal tissues regeneration

Membranes for periodontal tissues regeneration

The influence of collagen membranes and tetracycline on the PDGF-BB expression and osteoblast amount in bone defects healing: Experimental study in mice

Evaluation of Premature Membrane Exposure and Early Healing in Guided Bone Regeneration of Peri‐Implant Dehiscence and Fenestration Defects With a Slowly Resorbing Porcine Collagen Ribose Cross‐Linked Membrane: A Consecutive Case Series

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