Bioresorbable pH- and temperature-responsive injectable hydrogels-incorporating electrosprayed particles for the sustained release of insulin

Nguyen, Dang Tri; Phan, Vu To-Anh; Lee, Sang Soo; Thambi, Thavasyappan; Huynh, Dai Phu

doi:10.1016/j.polymdegradstab.2019.02.013

Cited by 32 publications

(9 citation statements)

References 33 publications

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“…21 Nguyen et al have recently described the in situ hydrogel formation of novel pentablock copolymer sols, where insulin was released from coformulated chitosan inclusions. 22 Photo-cross linked types have also been suggested, such as that described by Custodio et al for hydrogels formed from laminarin, a low molecular weight glucan. 23 Some can be placed subcutaneously as dried pellets to hydrate in situ and deliver peptides such as insulin long term.…”

Section: Hydrogelsmentioning

confidence: 98%

“…Specific and non-specific binding, chelation and charge-related interactions are of particular importance for designs to form the basis of insulin boost dosage in either triggered or closed loop release (in addition to a basal dose rate). 54 Light, magnetism, electrical signal, salts, pH and ionic strength mechanisms [55][56][57][58] are all capable of physicochemical stimulus-sensitive design into polymers used for gels for insulin delivery (Figure 11).…”

Section: Release Mechanism: 2 -Bolusmentioning

confidence: 99%

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Gels for constant and smart delivery of insulin

2020

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The focus of this review is the role of gelatinous materials for oral, transdermal and peritoneal insulin platforms as alternatives to the ubiquitous subcutaneous depot approach. Hydrogels that form hydrated, cohesive materials and the topologically complex micellar types can add ligand interaction, bond vulnerability and rheological characteristics to develop reliable programmed release, including closed loop (automated basal and bolus) activity in non-oral routes. In addition, the potential protection of the protein and likely increased paracellular uptake mean that orally active insulin is feasible. While unlikely to be suitable for closed loop delivery, the driver for gut absorption is not only to increase the convenience and decrease dosage trauma, but to target the mesentery-portal vasculature rather than peripheral tissue, thus improving hepatic glycogen equilibrium and reducing the obesogenic effect and hypoglycaemic episodes.

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Section: Hydrogelsmentioning

confidence: 98%

Section: Release Mechanism: 2 -Bolusmentioning

confidence: 99%

Gels for constant and smart delivery of insulin

2020

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“…The pentablock copolymers showed gelation at biological environment (pH 7.4, 37 °C), a controlled degradation rate and hence controlled release of the entrapped compound. Chitosan nanoparticles loaded with insulin were included and 15wt%–35wt% pentablock copolymer-controlled release of the agent was noticed without any initial burst [ 27 ].…”

Section: Stimuli-sensitive Hydrogelsmentioning

confidence: 99%

Emerging Role of Hydrogels in Drug Delivery Systems, Tissue Engineering and Wound Management

et al. 2021

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The popularity of hydrogels as biomaterials lies in their tunable physical properties, ability to encapsulate small molecules and macromolecular drugs, water holding capacity, flexibility, and controllable degradability. Functionalization strategies to overcome the deficiencies of conventional hydrogels and expand the role of advanced hydrogels such as DNA hydrogels are extensively discussed in this review. Different types of cross-linking techniques, materials utilized, procedures, advantages, and disadvantages covering hydrogels are tabulated. The application of hydrogels, particularly in buccal, oral, vaginal, and transdermal drug delivery systems, are described. The review also focuses on composite hydrogels with enhanced properties that are being developed to meet the diverse demand of wound dressing materials. The unique advantages of hydrogel nanoparticles in targeted and intracellular delivery of various therapeutic agents are explained. Furthermore, different types of hydrogel-based materials utilized for tissue engineering applications and fabrication of contact lens are discussed. The article also provides an overview of selected examples of commercial products launched particularly in the area of oral and ocular drug delivery systems and wound dressing materials. Hydrogels can be prepared with a wide variety of properties, achieving biostable, bioresorbable, and biodegradable polymer matrices, whose mechanical properties and degree of swelling are tailored with a specific application. These unique features give them a promising future in the fields of drug delivery systems and applied biomedicine.

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“…It has been reported that the release profiles and drug dose can be tailored by varying the different trigger signals 16 . The overview of available literature showed that there have been various approaches to activate the drug release such as electrical trigger signal, 16 magnetic field gradients, 17 pH, temperature, and electrochemical system 18‐20 . Till present, electrochemically controlled release system has been activated using an electrochemical cell consisting of several electrodes with certain electrode configuration.…”

Section: Introductionmentioning

confidence: 99%

Degradation‐triggered release from biodegradable metallic surfaces

et al. 2021

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This work is dedicated to the investigation of drug‐release control by a direct effect of degradation from biodegradable metallic surfaces. Degradation behaviors characterized by surface morphology, immersion, and electrochemical techniques demonstrated that curcumin‐coated zinc (c‐Zn) had a higher degradation rate compared to curcumin‐coated Fe (c‐Fe). High anodic dissolution rate due to the higher degradation rate and widely extended groove‐like degradation structure of c‐Zn propelled a higher curcumin release. On the other hand, a slower curcumin release rate shown by c‐Fe scaffolds is ascribed to its lower anodic dissolution and to its pitting degradation regime with relatively smaller pits. These findings illuminate the remarkable advantage of different degradation behaviors of degradable metallic surfaces in directly controlling the drug release without the need for external electrical stimulus.

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Bioresorbable pH- and temperature-responsive injectable hydrogels-incorporating electrosprayed particles for the sustained release of insulin

Cited by 32 publications

References 33 publications

Gels for constant and smart delivery of insulin

Gels for constant and smart delivery of insulin

Emerging Role of Hydrogels in Drug Delivery Systems, Tissue Engineering and Wound Management

Degradation‐triggered release from biodegradable metallic surfaces

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