No abstract

This work is dedicated to the investigation of drug‐release control by a direct effect of degradation from biodegradable metallic surfaces. Degradation behaviors characterized by surface morphology, immersion, and electrochemical techniques demonstrated that curcumin‐coated zinc (c‐Zn) had a higher degradation rate compared to curcumin‐coated Fe (c‐Fe). High anodic dissolution rate due to the higher degradation rate and widely extended groove‐like degradation structure of c‐Zn propelled a higher curcumin release. On the other hand, a slower curcumin release rate shown by c‐Fe scaffolds is ascribed to its lower anodic dissolution and to its pitting degradation regime with relatively smaller pits. These findings illuminate the remarkable advantage of different degradation behaviors of degradable metallic surfaces in directly controlling the drug release without the need for external electrical stimulus.

No abstract

Bone scaffold architecture affects the performance of bone scaffold significantly. Recently, functionally graded architecture (FGA) has received wide attention in bone scaffold application due to its architecture that mimics the cancellous bone architecture. Hence, this study aims to evaluate the mechanical properties of PLA specimens that adopt FGA fabricated using additive manufacturing via fused filament fabrication (FFF). The mechanical properties of FGA PLA specimen (1 GPa -2 Gpa) was tailored to the cancellous bone (modulus: 0.01 GPa – 2 GPa). The result shows that radially dense- in rod (RDR) has the highest Young’s Modulus, and yield strength. However, the relationship between cross section area of specimen needs to be considered in comparing the performance of FGA PLA specimen.