Bioresponsive metal–organic frameworks: Rational design and function

Morozova, Sofia M.; Sharsheeva, Aziza; Morozov, Maxim I.; Виноградов, А. В.; Hey‐Hawkins, Evamarie

doi:10.1016/j.ccr.2020.213682

Cited by 20 publications

(10 citation statements)

References 257 publications

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“…1 The structural diversity and functional variety of MOFs are based on a combination of metal ions or clusters, organic linkers, and their specic coordination resulting in porous crystal structures. 2,3 These advantageous features allow using MOFs as an engineering platform for targeted drug delivery systems with high loading capacity and controllable release. 4,5 Zeolitic imidazolate frameworks (ZIFs) are a specic subclass of MOFs comprising imidazolate linkers and metal ions with structures similar to aluminosilicate zeolites.…”

Section: Introductionmentioning

confidence: 99%

Degradation kinetic study of ZIF-8 microcrystals with and without the presence of lactic acid

et al. 2021

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Section: Introductionmentioning

confidence: 99%

Degradation kinetic study of ZIF-8 microcrystals with and without the presence of lactic acid

et al. 2021

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“…Metal–organic frameworks (MOFs) are a class of microporous materials composed by the coordination of metal ions and organic ligands . MOFs, thanks to their appealing features, such as rich chemical surface, biocompatibility, and good stability, have shown promising results in the bioanalytical field, especially for biosensing, bioimaging, biomedical applications, and bioremediation applications. − Despite the benefits of these materials as host platforms for enzymes, , the combination with luciferase has been seldom explored. , A very preliminary study was reported, in which luciferase was immobilized onto MIL-53(Al) and NH 2 -MIL-88(Fe) via covalent and noncovalent bindings. Those approaches provided a significant improvement in luciferase stability; however, no full characterization was obtained in terms of thermal stability, storage influence, and potential reusability and applicability (e.g., in terms of limit of detection (LOD) or precision).…”

mentioning

confidence: 99%

Novel Nanozeolitic Imidazolate Framework (ZIF-8)–Luciferase Biocomposite for Nanosensing Applications

Martínez-Pérez-Cejuela

Gregucci

Calabretta

et al. 2022

Anal. Chem.

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The identification of new strategies to improve the stability of proteins is of utmost importance for a number of applications, from biosensing to biocatalysis. Metal−organic frameworks (MOFs) have been shown as a versatile host platform for the immobilization of proteins, with the potential to protect proteins in harsh conditions. In this work, a new thermostable luciferase mutant has been selected as a bioluminescent protein model to investigate the suitability of MOFs to improve its stability and prompt its applications in real-world applications, for example, ATP detection in portable systems. The luciferase has been immobilized onto zeolitic imidazolate framework-8 (ZIF-8) to obtain a bioluminescent biocomposite with enhanced performance. The biocomposite ZIF-8@luc has been characterized in harsh conditions (e.g., high temperature, non-native pH, etc.). Bioluminescence properties confirmed that MOF enhanced the luciferase stability at acidic pH, in the presence of organic solvents, and at −20 °C. To assess the feasibility of this approach, the recyclability, storage stability, precision, and Michaelis−Menten constants (K m ) for ATP and D-luciferin have been also evaluated. As a proof of principle, the suitability for ATP detection was investigated and the biocomposite outperformed the free enzyme in the same experimental conditions, achieving a limit of detection for ATP down to 0.2 fmol.

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“…Table 2 represents a list of MOFs with their biosensing applications. The biosensors detect the targeting agent based on the various techniques like electrochemical, colorimetric, luminescence, and electroluminescent methods, as represented in Figure 4 [ 64 ].…”

Section: Biological Applications Of Mofmentioning

confidence: 99%

“… Representation of the many detection techniques utilized in the MOF-based biosensor for the sensing of biomolecules, bacteria, ions, and cells (adapted from [ 64 ]). …”

Section: Figurementioning

confidence: 99%

Progressive Trends on the Biomedical Applications of Metal Organic Frameworks

et al. 2022

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Novel materials have been developed because of technological advancements combined with material research. Metal-organic frameworks (MOF) technology has been investigated for biomedical applications in this line. Nonetheless, as our team has learned from current literature, selecting metal ions/organic linkers, synthesis techniques, water stability/solubility, toxicity, and the possibility of biomolecules/drugs (enzyme, protein, DNA/RNA, and antibodies, among others) tagging/conjugation are the major challenges/factors. These issues/factors have an impact on MOFs’ performance in biomedical applications, and they also raise a lot of doubts about its real-time biological utility in the near future. We targeted a comprehensive review on the MOFs for biomedical applications to keep these considerations in mind. The evolution of MOF technology is based on their interesting features such as biological or pharmacological activity, biocompatibility, limited toxicity, and particular host–guest interactions, as well as environmental friendliness. In this paper, we have summarized the state-of-the-art progress pertaining to MOFs’ biomedical applications such as biosensing, biomedical, and drug delivery applications in this field that is still very new.

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Bioresponsive metal–organic frameworks: Rational design and function

Cited by 20 publications

References 257 publications

Degradation kinetic study of ZIF-8 microcrystals with and without the presence of lactic acid

Degradation kinetic study of ZIF-8 microcrystals with and without the presence of lactic acid

Novel Nanozeolitic Imidazolate Framework (ZIF-8)–Luciferase Biocomposite for Nanosensing Applications

Progressive Trends on the Biomedical Applications of Metal Organic Frameworks

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