Biorevitalization of postmenopausal labia majora, the polynucleotide/hyaluronic acid option

Palmieri, Isabella Pia; Raichi, Mauro

doi:10.15761/ogr.1000135

Cited by 13 publications

(27 citation statements)

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“…This innovative concept of "PN-HPT™ priming" is most likely to apply to many procedures, both in wound care 10 and in dermatology/aesthetic medicine. 11 The present Consensus Project supports a combination approach for skin priming and revitalization with PN-HPT™-based medical devices. Specifically, almost all the Experts agree on using PN-HPT™ in association with hyaluronic acid (PNHA) in combined formulations in the same device.…”

Section: Benefits Of Pn-hpt™-based Skin Treatmentmentioning

confidence: 73%

Consensus report on the use of PN‐HPT™ (polynucleotides highly purified technology) in aesthetic medicine

Cavallini

Bartoletti

Maioli

et al. 2020

J of Cosmetic Dermatology

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Section: Benefits Of Pn-hpt™-based Skin Treatmentmentioning

confidence: 73%

Consensus report on the use of PN‐HPT™ (polynucleotides highly purified technology) in aesthetic medicine

Cavallini

Bartoletti

Maioli

et al. 2020

J of Cosmetic Dermatology

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“…Such compounds have evolved to evoke appropriate tissue responses to the wound, with the goal of facilitating healing. A PN and HA-based hydrogel has yielded promising results in soft tissue [17] and intra-articular [18] applications. In the present paper we investigated the effects of a PN/Hyaluronic acid hydrogel on primary fibroblasts of gingival origin and assessed cell responses using assays that are relevant to wound healing.…”

Section: Introductionmentioning

confidence: 99%

A Biomimetic Polynucleotides–Hyaluronic Acid Hydrogel Promotes Wound Healing in a Primary Gingival Fibroblast Model

et al. 2021

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Polynucleotides (PN) have long been known as an effective supportive therapy for wound healing. The present study investigated whether a hydrogel formulation containing PN and hyaluronic acid (PN + HA) could promote wound healing in an in vitro model of gingival fibroblasts. PN promoted cell growth and viability as assessed by different assays, and PN + HA, though not significantly further increasing cell growth as compared to PN, supported the formation of dense multilayered cell nodules. PN promoted fibroblasts’ clonogenic efficiency and PN + HA further enhanced the formation of more numerous dense colonies. PN + HA appeared to significantly increase the expression of collagen 1a1 and 3a1, while not affecting proteoglycans deposition. Interestingly, when tested in a scratch assay, PN + HA achieved gap closure after 48 h, while cells in the comparison groups had not completely bridged the scratch even after 96 h. Taken together, these results demonstrate that PN + HA is a promising candidate for a supportive therapy to promote soft tissue healing in the oral cavity.

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“…Finally, positive outcomes were obtained with only one treatment and lasted up to 5 months. Based on this result and the lack of specific literature, we can assume that the treatment might be repeated not earlier than 6/12 months (depending on the subjective and individual response), which means less frequent application than other currently used approaches (18)(19)(20)(21)(22).…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, hyaluronic acid injections have been proposed as a therapeutic option: hyaluronic acid injection aims to improve tissue healing and the extracellular matrix to reduce the symptoms of GSM. The patient may appreciate the results after a while, but the effects do not last long, and the patient needs to repeat the treatment frequently to maintain the results 22 …”

Section: Introductionmentioning

confidence: 99%

“…The patient may appreciate the results after a while, but the effects do not last long, and the patient needs to repeat the treatment frequently to maintain the results. 22 The rationale of using ADSC in GSM treatment lies in their ability to differentiate to a cell lineage according to the tissue features in which they have implanted. 14 At the level of an aging vaginal mucosa, they might increase the content of elastin-producing fibroblasts, so restoring tissue turgor, elasticity, and spontaneous lubrication.…”

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A new approach to regenerative medicine in gynecology

Mantovani

Gennai²,

Russo³

2021

Intl J Gynecology & Obste

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Therapies based on the autologous grafting of adult mesenchymal stem cells (MSC) are known to effectively accelerate the skin's healing and the regenerative processes of mesenchymal tissues. [1][2][3] Regenerative medicine mostly uses adipose-derived stem cells (ADSC), which are pluripotent adult progenitor cells derived from embryonic connective tissue. 3,4 Adipose tissue is found throughout the adult human body in bone marrow, adipose tissue, muscle, and dermis. 3,4 ADSC share similar characteristics with bone marrow mesenchymal cells. Still, they have some advantages, including their easy availability and harvesting through a less invasive surgical procedure. 3,[5][6][7] Compared with the bone marrow, the adipose tissue is richer in adult MSCs and stromal components (the stromal vascular fraction [SVF]). 6,7 ADSC have the potential to differentiate into mesodermal cells (e.g. adipocytes, cartilage, bone, and skeletal muscle) and cells of non-mesodermal lineage (e.g. neurons, cardiomyocytes, and vascular endothelial cells). 3,6,7 Moreover, ADSC can release trophic and soluble factors with anti-fibrotic, anti-apoptotic, and pro-angiogenic properties that provide ADSC with regenerative and immune-modulatory activities. 3,7 The ADSCs regenerative and anti-inflammatory properties currently find therapeutic applications in various medical fields including, but not limited to, reconstructive and esthetic surgery

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Biorevitalization of postmenopausal labia majora, the polynucleotide/hyaluronic acid option

Cited by 13 publications

References 0 publications

Consensus report on the use of PN‐HPT™ (polynucleotides highly purified technology) in aesthetic medicine

Consensus report on the use of PN‐HPT™ (polynucleotides highly purified technology) in aesthetic medicine

A Biomimetic Polynucleotides–Hyaluronic Acid Hydrogel Promotes Wound Healing in a Primary Gingival Fibroblast Model

A new approach to regenerative medicine in gynecology

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