Biosensors for detection of Low-Density Lipoprotein and its modified forms

Andrade, César A.S.; Oliveira, Maria D.L.; Faulin, Tanize do Espirito Santo; Hering, Vitor Renaux; Abdalla, Dulcinéia Saes Parra

doi:10.5772/19938

Cited by 7 publications

(7 citation statements)

References 83 publications

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“…EC (bio)sensor configuration typically comprises two main parts: (i) immobilized recognition element providing the selectivity to the target analyte (T) and (ii) the EC transducer serving as a converter of the biorecognition event to an electronic signal. 107,108 …”

Section: Design Of Electrochemical Sensors For Detection Of Protein Biomarkers Relevant To Mtbimentioning

confidence: 99%

Electrochemical sensing of blood proteins for mild traumatic brain injury (mTBI) diagnostics and prognostics: towards a point-of-care application

2021

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Section: Design Of Electrochemical Sensors For Detection Of Protein Biomarkers Relevant To Mtbimentioning

confidence: 99%

Electrochemical sensing of blood proteins for mild traumatic brain injury (mTBI) diagnostics and prognostics: towards a point-of-care application

2021

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“…As the biological species is monitored by a sensing element in a biosensor, measurable electrical signals proportional to the concentration of the analyte are generated. As shown in Figure 2, a biosensor is mainly composed of a bioreceptor, transducer, and electronic module [55]. Various sensing elements, such as antibodies, cells, enzymes, and tissues, can be used as bioreceptors that interact with specific analytes.…”

Section: Biosensorsmentioning

confidence: 99%

mentioning

confidence: 99%

Research Progress on Conducting Polymer-Based Biomedical Applications

2019

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Conducting polymers (CPs) have attracted significant attention in a variety of research fields, particularly in biomedical engineering, because of the ease in controlling their morphology, their high chemical and environmental stability, and their biocompatibility, as well as their unique optical and electrical properties. In particular, the electrical properties of CPs can be simply tuned over the full range from insulator to metal via a doping process, such as chemical, electrochemical, charge injection, and photo-doping. Over the past few decades, remarkable progress has been made in biomedical research including biosensors, tissue engineering, artificial muscles, and drug delivery, as CPs have been utilized as a key component in these fields. In this article, we review CPs from the perspective of biomedical engineering. Specifically, representative biomedical applications of CPs are briefly summarized: biosensors, tissue engineering, artificial muscles, and drug delivery. The motivation for use of and the main function of CPs in these fields above are discussed. Finally, we highlight the technical and scientific challenges regarding electrical conductivity, biodegradability, hydrophilicity, and the loading capacity of biomolecules that are faced by CPs for future work. This is followed by several strategies to overcome these drawbacks.

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“…107,109,110 However, this was used to explore potential interactions between LDL and the vasculature, rather than to quantify LDL-C levels In addition, although QCM biosensors have been found to be very useful as laboratory-based investigative tools, their cost has Table 6 Percentage total error results of a single measurement based on the first result (no replication) for five homogeneous HDL-C and LDL-C assay methods 58 …”

Section: -106mentioning

confidence: 99%

“…107 Piezoelectric devices have been extensively investigated as the basis for sensing due to their small size, small sample requirements and high sensitivity.…”

Section: -106mentioning

confidence: 99%

The evolution of selective analyses of HDL and LDL cholesterol in clinical and point of care testing

Ahmadraji

Killard

2013

Anal. Methods

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Cardiovascular disease is a leading cause of death worldwide and is caused by the build up of atherosclerotic plaques in the vasculature. It is now well established that the formation of these plaques is closely related to levels of both high density lipoprotein (HDL) and low density lipoprotein (LDL) cholesterol. Thus, the importance of the effective measurement of these is critical for the improved diagnosis and management of atherosclerosis. This review discusses the emergence of methodologies for the selective determination of both LDL and HDL cholesterol. It begins with an explanation of the first methodologies based on ultracentrifugation and precipitation techniques, the development of reference methods, through to the emergence of methodologies suitable for routine laboratory use, followed by the development of professional use, point of care technologies. Finally, the current status of selective tests for cholesterol based on biosensor methodologies is reviewed and the potential for application in consumer diagnostics is discussed.

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Biosensors for detection of Low-Density Lipoprotein and its modified forms

Cited by 7 publications

References 83 publications

Electrochemical sensing of blood proteins for mild traumatic brain injury (mTBI) diagnostics and prognostics: towards a point-of-care application

Electrochemical sensing of blood proteins for mild traumatic brain injury (mTBI) diagnostics and prognostics: towards a point-of-care application

Research Progress on Conducting Polymer-Based Biomedical Applications

The evolution of selective analyses of HDL and LDL cholesterol in clinical and point of care testing

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