Biosimilars: achieving long-term savings and competitive markets

Mestre-Ferrandiz, J.; Towse, Adrian; Berdud, Mikel

doi:10.5639/gabij.2016.0503.027

Cited by 2 publications

(2 citation statements)

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“…Drug development for chronic lung diseases continues to lag behind other fields of medicine [153] and the lack of effective and curative therapies for diseases like COPD has meant that only lung transplantation offers any real hope for prolonged survival. For many years, this option has not been available to PLWH, HIV being considered either an absolute or a relative contraindication to lung transplantation [154,155].…”

Section: The Future Of Respiratory Care In Plwhmentioning

confidence: 99%

HIV and chronic lung disease

Leung

2022

Current Opinion in HIV and AIDS

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Purpose of reviewAs people living with human immunodeficiency virus (HIV, PLWH) age, aging-related comorbidities have come into focus as major challenges to their overall health. In this review, an in-depth overview of the two most commonly encountered chronic lung diseases in PLWH, chronic obstructive pulmonary disease (COPD) and lung cancer, is provided. Recent findingsThe risk for both COPD and lung cancer remains significantly higher in PLWH compared to the HIVuninfected population, although fortunately rates of lung cancer appear to be declining over the last two decades. Outcomes for PLWH with these conditions, though, continue to be poor with worse survival rates in comparison to the general population. PLWH still face major barriers in accessing care for these conditions, including a higher likelihood of being underdiagnosed with COPD and a lower likelihood of being referred for lung cancer screening or treatment. A lack of evidence for optimal treatment strategies for both COPD and lung cancer still hampers the care of PLWH with these conditions. SummaryCOPD and lung cancer represent substantial burdens of disease in PLWH. Improved access to standard-ofcare screening and treatment and greater investigation into therapeutic responses specifically in this population are recommended.

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Section: The Future Of Respiratory Care In Plwhmentioning

confidence: 99%

HIV and chronic lung disease

Leung

2022

Current Opinion in HIV and AIDS

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“…The issue of extrapolation is a topic of great interest. EMA has backed up its position with evidence from post-marketing authorization [15]. In the US, FDA approved Infl ectra for the same indications as Remicade.…”

Section: Extrapolationmentioning

confidence: 99%