Biospecimens and the ABCD study: Rationale, methods of collection, measurement and early data

Uban, Kristina A.; Horton, Megan; Jacobus, Joanna; Heyser, Charles J.; Thompson, Wesley K.; Tapert, Susan F.; Madden, Pamela A. F.; Sowell, Elizabeth R.

doi:10.1016/j.dcn.2018.03.005

Cited by 123 publications

(95 citation statements)

References 96 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Youth and their parent/guardian were in separate, private rooms during study participation to maintain confidentiality of their survey responses. The baseline measures included questionnaires, neurocognitive testing, biological samples, and an MRI scan (Lisdahl et al, 2018; Luciana et al, 2018; Uban et al, 2018). Study assessment was completed over an 8‐hour research session (or two 4‐hour sessions).…”

Section: Methodsmentioning

confidence: 99%

Parental Family History of Alcohol Use Disorder and Neural Correlates of Response Inhibition in Children From the Adolescent Brain Cognitive Development (ABCD) Study

Lees

Aguinaldo

Squeglia

et al. 2020

Alcoholism Clin & Exp Res

Self Cite

View full text Add to dashboard Cite

Background: Youth whose parents have alcohol use disorder (AUD) are at higher risk for earlier initiation and greater magnitude of alcohol use, and have a higher likelihood of developing an AUD than their peers without parental history of AUD. This increased risk may be partly attributable to altered development of inhibitory control and related neural circuitry. This study examined neural activation during a motor response inhibition Stop Signal Task (SST) in substance-na€ ıve youth aged 9 to 10 years with and without parental family history of AUD.Methods: Baseline cross-sectional survey and functional magnetic resonance imaging (fMRI) data were drawn from 6,898 youth in the US-based Adolescent Brain Cognitive Development Study. Generalized additive mixed models were conducted to examine the association between maternal, paternal, and parental (both mother and father) family history of AUD with neural activation during successful and failed response inhibition. Family history interactions with sex and stratification by ethnicity were explored.Results: Of 6,898 participants, 951 (14%) were family history positive for any parental AUD. Paternal history of AUD was associated with greater activation for successful inhibition in the right medial orbital frontal gyrus, compared to youth with no family history. Maternal history of AUD was associated with greater activation for failed response inhibition among females in the cerebellum, compared to females with no such history. Parental history (both mother and father) of AUD was associated with greater activation during successful inhibition in the left paracentral gyri and left superior parietal lobule. Maternal history and parental history of AUD findings were accounted for by a family history of substance use disorder in general. All effect sizes were relatively small.Conclusions: Substance-na€ ıve children with a parental family history of AUD exhibit greater neural activation in some regions of the fronto-basal ganglia and cerebellar networks when they successfully or unsuccessfully inhibit a response as compared to children with no such family history. This unique neural response pattern could reflect a compensatory response and may represent an inherent neurobiological vulnerability to risk-related behaviors in these youth which will be examined in future longitudinal analyses of this cohort.

show abstract

Section: Methodsmentioning

confidence: 99%

Parental Family History of Alcohol Use Disorder and Neural Correlates of Response Inhibition in Children From the Adolescent Brain Cognitive Development (ABCD) Study

Lees

Aguinaldo

Squeglia

et al. 2020

Alcoholism Clin & Exp Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…Furthermore, a recent nationwide longitudinal study has been launched to assess the extent to which genetic and environmental factors influence the variation and covariation between a plethora of biological and psychosocial measures, such as brain structure and function and neurocognitive measures, in developing adolescents, which will include a subset of twins (Iacono et al, ). Importantly, the study also aims to collect various bio‐specimens including blood, saliva, urine, hair, and fecal samples to assess the impact of genomic, transcriptomic, epigenomic, metabolomic, and microbiome factors on brain development and behavior (Uban et al, ). As the field of psychiatric research moves forward, the use of transcriptomic and other omic datasets will help provide a more comprehensive understanding of the processes that cause psychiatric diseases and hopefully help overcome current limitations in generating clinically useful tests for psychiatric diseases (Kapur, Phillips, & Insel, ).…”

Section: Concepts and Methodsologies Used To Study Suicide Transcriptomentioning

confidence: 99%

Suicide and suicide behaviors: A review of transcriptomics and multiomics studies in psychiatric disorders

Zhou

Lutz

Ibrahim

et al. 2018

J of Neuroscience Research

View full text Add to dashboard Cite

Aberrant gene expression can contribute to brain and nervous system dysfunction that causes many psychiatric illnesses. Here, we review how transcriptomic approaches have deepened our understanding of the neurobiological underpinnings of psychiatric disorders and how they have to the identification of biomarkers for these disorders, with a focus on their relevance to suicide and suicide behaviors. We begin by providing an overview of the genetic, transcriptomic, and epigenetic factors (including non‐coding RNAs) implicated in suicide and their roles in the regulation of gene expression. Then, we highlight the unique benefits and limitations of using either postmortem brain or peripheral tissues in transcriptomic analyses. We examine the current shift from candidate gene to genome‐wide approaches in psychiatric research, which are concurrently emerging with the increased consideration of the Research Domain Criteria (RDoC) framework for classifying mental illnesses. Furthermore, we discuss the use of transcription networks and how they can be integrated into multiomic analyses. Finally, we end by highlighting recent findings of peripheral markers of suicide risk identified through the use of transcriptomic tools. Technological advancements and increased accessibility of these technologies are drastically shaping the current research landscape. We present an overview of the significant changes currently taking place to usher in a new era of psychiatric research.

show abstract

“…Research procedures of each site were governed by local, state, and federal regulations, overseen by local and/or centralized human subjects institutional review boards, and monitored by the ABCD External Advisory Board and the Bioethics and Medical Oversight advisory panel (Bjork, Straub, Provost, & Neale, 2017;Clark et al, 2017). All participants underwent informed consent or assent procedures (Uban et al, 2018).…”

Section: Participantsmentioning

confidence: 99%

Distinguishing Remitted Bipolar Disorder From Remitted Unipolar Depression in Preadolescent Children: A Neural Reward Processing Perspective

Alloy

Smith

2020

Biological Psychiatry

View full text Add to dashboard Cite

Bipolar disorder (BD) and unipolar depression (UD) are two severe mood disorders, with BD often misdiagnosed as UD. Given their severity and high rates of misdiagnosis, it is of paramount importance to understand the psychological and neurobiological mechanisms underlying these disorders to enhance our ability to diagnose, treat, and prevent them effectively. Many neuroimaging studies have shown that mood disorders are associated with abnormal reward-related responses, particularly in the ventral striatum (VS). Yet, the link between mood disorders and reward-related responses in other regions remains inconclusive, thus limiting our understanding of the pathophysiology of mood disorders. To provide insights into the neurobiological underpinnings of reward processing dysfunction in mood disorders, two studies were conducted. Study 1 (Chapter 2) is a coordinate-based meta-analysis of 41 whole-brain neuroimaging studies encompassing reward-related responses from a total of 794 patients with major depressive disorder (MDD), and 803 healthy controls (HC). It aims to address inconsistencies in the literature by synthesizing the literature quantitatively. The findings of Study 1 indicate that MDD is associated with opposing abnormalities in the reward circuit: hypo-responses in the VS and hyper-responses in the orbitofrontal cortex (OFC). These findings provide a foundation for Study 2 (Chapter 3) and help to reconceptualize our understanding of reward processing abnormalities in UD by suggesting a role for dysregulated corticostriatal connectivity. Study 2 is the first fMRI study to employ region-of-interest (VS and OFC), whole-brain, activation, connectivity, and network analyses to examine the similarities and differences in reward-related brain activation patterns between 46 children with remitted bipolar I disorder, 48 children with remitted MDD, and 46 HC. iii The results of Study 2 revealed differential connectivity in corticostriatal circuitry during reward processing among BD, UD, and HC in pre-adolescence. Specifically, BD exhibited increases in OFC-VS connectivity during anticipation of larger reward, whereas UD and HC showed no changes in OFC-VS connectivity across anticipation conditions ranging from large loss to large reward. Furthermore, BD and UD generally showed more abnormal whole-brain responses to reward anticipation in accordance with the valence of the stimuli than HC. These findings suggest that preadolescents with BD and UD exhibit reward processing dysfunction during reward anticipation relative to HC even outside of acute periods of illness. Taken together, the dissertation provides novel insight into the nature of reward processing abnormalities in mood disorders in pre-adolescence. As early onset BD or UD often is associated with long treatment delays and a persistently pernicious illness course, this dissertation may aid efforts to ensure early accurate diagnosis, which may improve our ability to intervene with appropriate treatments and result in a more benign prognosis and course of illnes...

show abstract

Biospecimens and the ABCD study: Rationale, methods of collection, measurement and early data

Cited by 123 publications

References 96 publications

Parental Family History of Alcohol Use Disorder and Neural Correlates of Response Inhibition in Children From the Adolescent Brain Cognitive Development (ABCD) Study

Parental Family History of Alcohol Use Disorder and Neural Correlates of Response Inhibition in Children From the Adolescent Brain Cognitive Development (ABCD) Study

Suicide and suicide behaviors: A review of transcriptomics and multiomics studies in psychiatric disorders

Distinguishing Remitted Bipolar Disorder From Remitted Unipolar Depression in Preadolescent Children: A Neural Reward Processing Perspective

Contact Info

Product

Resources

About