Biosurfactant assisted silver nanoparticle synthesis: a critical analysis of its drug design aspects

Abstract

Silver nanoparticles exhibit wide dimensional antimicrobial and antifungal properties and therefore they are preferred for their applications in medical and cosmetics sector. They are synthesized by physical, chemical and biochemical methods. Biochemical methods are the best technique because of their non-toxic and energy efficient nature and hence are alternatives for the production of silver nanoparticles. One of the biochemical methods proposed in this work is the use of microbial surfactant for the synthesis of silver nanoparticles. The synthesis of surfactant was performed using Bacillus subtilis. The surfactant thus produced was analyzed by emulsification assay, oil spilling test, and hemolytic test. Silver nanoparticles synthesized from surfactant were observed by UV–Vis spectroscopy in the range of 400–600 nm. The surface plasmon resonance peak was observed at 410 nm corresponding to the peak of silver nanoparticles. The x-ray diffraction pattern showed an intense diffraction peak at with an average particle size of 14 nm. In silico drug designing of surfactin A synthetase C was performed using Schrödinger software for identification of novel drugs. All the two identified ligands, leucine and lysine, exhibited docking with the target protein which shows their potential as drug molecules.

Microbial Surfactants: The Next Generation Multifunctional Biomolecules for Applications in the Petroleum Industry and Its Associated Environmental Remediation

“…Also, biosurfactants have been proven to have potential in metallic nanoparticle synthesis [171]. Eswari et al [193] synthesized silver nanoparticles from AgNO 3 using surfactin from Bacillus subtilis . A blend of biosurfactant and nanoparticles serves as a dual function recovery mechanism for oil recovery [194].…”

Microbial Surfactants: The Next Generation Multifunctional Biomolecules for Diverse Applications

“…Also, biosurfactants have been proved to have potential in metallic nanoparticle synthesis [171]. Eswari et al [193] synthesized silver nanoparticles from AgNO3 using surfactin from Bacillus subtilis. A blend of biosurfactant and nanoparticles serve as a dual function recovery mechanism for oil recovery [194].…”

“…Silver and gold nanoparticles EPS from algae Biosurfactant producing organisms converts (Ag-Au) NO3 to silver/gold particle using enzyme such as nitrate reductase. [176,193] Agriculture Improvement of soil quality…”

Green Synthesis of Silver Nanoparticles Using a Biosurfactant from Bacillus cereus UCP 1615 as Stabilizing Agent and Its Application as an Antifungal Agent

“…Since AgNPs have nontoxic, inorganic, and antibacterial properties [4], they are used in several applications such as in drug delivery, ointments, nanomedicine, chemical detection, data storage, cell biology, agriculture, cosmetics, textiles, food industry, photocatalytic organic dye degradation activity, antioxidants, and antimicrobial agents [1]. The reason for the interest in using silver in the form of nanoparticles, especially in medical applications, is that the release of this metal is very fast and uncontrollable in the form of silver salts, but somewhat inefficient in the form of bulk metal [5].…”

“…Among the green synthesis approaches for AgNP preparation, there is the Tollens method, in which saccharides are used to reduce silver ions in the presence of ammonia [4]. Le et al [5] proposed to associate with this method stabilizers, including surfactants, to compose the surface layer (outer core) of NPs.…”