Biosynthesis and Anti‐inflammatory Activity of Zinc Oxide Nanoparticles Using Leaf Extract of Senecio chrysanthemoides

Abstract

Nanotechnology has recently appeared as an important study subject in modern material sciences. Greener synthesis of nanoparticles has gained the attention of many scientists because of its integral characteristics such as effectiveness, eco-friendly, and low cost. In the present study by following the green synthesis approach, zinc oxide nanoparticles (ZnO NPs) were formed for the very first time by using Senecio chrysanthemoides leaf extract as a reducing agent. The UV-Vis spectrophotometer was used to study the synthesized ZnO NPs, and the specific peak was found to be at 349 nm. The characteristic Fourier transform infrared (FTIR) peak was found to be at 449 cm-1 which displays the peak of ZnO molecules. The surface morphology of the ZnO NPs was determined via scanning electron microscopy (SEM). The energy-dispersive X-ray spectroscopy (EDX) study showed that the synthesized ZnO NPs are present at the weight percentage of 66.38%. The X-ray diffraction (XRD) spectrum confirmed the hexagonal phase wurtzite structure, with the average particle size of 31 nm, and demonstrated the crystalline structure of ZnO NPs. Additionally, to all these experiments, we compared the anti-inflammatory properties of biogenic ZnO NPs to a standard drug. Biosynthesized ZnO NPs have revealed an effective anti-inflammatory activity at a higher concentration (100 mL-1) and showed 73% inhibition in comparison with diclofenac sodium drug. Zinc oxide was shown to be compatible with diclofenac sodium, according to the results. The ZnO NPs produced using the greener synthesis process have the potential to be used in a broad range of fields and also used as a good anti-inflammatory agent.

Comparative Anti-inflammatory Activity of Silver and Zinc Oxide Nanoparticles Synthesized Using Ocimum tenuiflorum and Ocimum gratissimum Herbal Formulations

“…On the other hand, ZnONPs have shown promise in fighting inflammation. Studies have shown that they can be made in a green way using plant extracts, such as Senecio chrysanthemoides, Euphorbia retusa, and Kalanchoe pinnata [22]. These biosynthesized ZnONPs have been shown to reduce inflammation through mechanisms that involve activating caspase-8 and stopping the production of cytokines that cause inflammation.…”

Cytotoxicity and Characterization of Zinc Oxide and Silver Nanoparticles Synthesized Using Ocimum tenuiflorum and Ocimum gratissimum Herbal Formulation

“…The EDX spectra displayed the elemental composition, with silver and carbon as predominant elements, suggesting the influence of herbal extracts. In the case of ZnONPs, SEM images revealed distinctive rod-like to short prism shapes, highlighting the versatility of morphology achievable through green synthesis [ 16 ]. The EDX spectra validated the existence of zinc, carbon, and oxygen, in alignment with the synthesis process.…”

Recent Advances in Nanotechnology-Based Drug Delivery Systems for the Diagnosis and Treatment of Reproductive Disorders

“…Additionally, ongoing research is exploring the use of nanomaterials for diagnostic purposes, such as imaging and sensing techniques, further expanding their potential in the field of medicine . Nanotechnology holds promise to treat many chronic diseases, which include cardiovascular, neurological, gastrointestinal, autoimmune inflammatory, infectious, and reproductive diseases, as well as various types of cancer …”

“…Additionally, ongoing research is exploring the use of nanomaterials for diagnostic purposes, such as imaging and sensing techniques, 7 further expanding their potential in the field of medicine. 8 Nanotechnology holds promise to treat many chronic diseases, which include cardiovascular, 9 neurological, 10 gastrointestinal, 11 autoimmune inflammatory, 12 infectious, 13 and reproductive diseases, 14 as well as various types of cancer. 15 With the help of nanoscience, reproductive assistive technology has revolutionized the field of fertility treatments, and scientists have been able to develop innovative methods that improve the success rates of procedures such as in vitro fertilization (IVF) and sperm selection by utilizing nano-technology.…”