Biosynthesis of bacteriocins in lactic acid bacteria

Nes, Ingolf F.; Diep, Dzung B.; Håvarstein, Leiv Sigve; Brurberg, May Bente; Eijsink, Vincent G. H.; Holo, Helge

doi:10.1007/978-94-009-1774-3_3

Cited by 244 publications

(465 citation statements)

References 73 publications

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“…This observation is in contrast to what has been described for the production of bacteriocins in lactobacilli, where only a specific type II bacteriocin-like peptide (CS functional homolog) appears to be involved in regulation of production [5,6,8,14,15]. Activation of transcription of the genes under control of cbn promoters requires a two-component signal transduction system composed of the putative peptide pheromone receptor CbnK and its corresponding response regulator CbnR.…”

Section: Cs and Cb2 Control Cbn Promoter Activity Via Cbnk And Cbnrcontrasting

confidence: 74%

“…The encoding genes are generally located directly upstream of the genes encoding the two-component regulatory system that is supposed to be triggered by these peptides (for reviews see 8,11,14,15). Based on these characteristics, the cbnS gene represents the most likely candidate to encode a second peptide pheromone involved in regulation of carnobacteriocin production (Fig.…”

Section: Identification Of a Second Peptide Pheromone Encoded By Pcp40mentioning

confidence: 99%

“…However, experimental evidence supporting regulatory cross talk has not been presented to date. The regulatory direct repeat sequence motifs appears to be conserved among several antimicrobial peptide biosynthesis systems, as they are also found in the promoter regions of genes involved in production of bacteriocins by various Lactobacillus species (L. plantarum C11, L. curvatus LTH1174, L. Sakei Lb706, Lb674) [7,14,15]. Moreover, for some of these repeats it has been shown that they act as the target site for the corresponding response regulator [21,22].…”

Section: Introductionmentioning

confidence: 99%

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A two-component signal-transduction cascade in Carnobacterium piscicola LV17B: two signaling peptides and one sensor-transmitter

et al. 2001

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A two-component signal-transduction cascade in Carnobacterium piscicola LV17B Kleerebezem, M; Kuipers, Oscar; de Vos, WM; Stiles, ME; Quadri, LEN; Vos, Willem M. de; Stiles, Michael E.; Quadri, Luis E.N. Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. AbstractIn the lactic acid bacterium Carnobacterium piscicola LV17B a peptide-pheromone dependent quorum-sensing mode is involved in the regulation of bacteriocin production. Bacteriocin CB2 was identified as an environmental signal that induces bacteriocin production. Here, we demonstrate that a second 24 amino acid peptide (CS) also induces bacteriocin production. Transcription activation of several carnobacteriocin operons is triggered by CB2 or CS via a two-component signal transduction system composed of CbnK and CbnR.

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Section: Cs and Cb2 Control Cbn Promoter Activity Via Cbnk And Cbnrcontrasting

confidence: 74%

Section: Identification Of a Second Peptide Pheromone Encoded By Pcp40mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A two-component signal-transduction cascade in Carnobacterium piscicola LV17B: two signaling peptides and one sensor-transmitter

et al. 2001

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“…Many lactic acid bacteria, such as members of the genera Lactococcus, Lactobacillus and Pediococcus, secrete antimicrobial peptides called bacteriocins (Jack et al, 1995;Venema et al, 1995a;Nes et al, 1996). These peptides are usually directed against closely related species and may therefore provide the producing organism with a selective advantage over its natural competitors (Dykes, 1995).…”

Section: Introductionmentioning

confidence: 99%

Pheromone‐induced production of antimicrobial peptides in Lactobacillus

Brurberg

Nes

Eijsink

1997

Molecular Microbiology

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158

176

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SummaryProduction of the bacteriocin sakacin P by Lactobacillus sake LTH673 is dependent on a secreted 19-residue peptide pheromone (IP-673). The gene encoding IP-673 (sppIP ) was identified and sequenced. SppIP was shown to be co-transcribed with genes encoding a histidine kinase (sppK ) and a response regulator (sppR ) typical for signal transduction in bacteria. Further sequencing and transcription studies have shown that IP-673 induces transcription of its own gene and of what are often considered to be all genes necessary for bacteriocin production and immunity. Studies with a reporter gene showed that the promoter in front of the sakacin P structural gene (sppA) is strictly regulated. The promoter in front of sppIP turned out to be less strictly regulated, and low basal promoter activity could be detected in uninduced cells. Bacteriocin production in Bac ¹ isolates of L. plantarum C11 could be induced by the non-cognate IP-673 only after the introduction of sppK, indicating that sppK encodes the pheromone receptor. These results show that bacteriocin production in lactobacilli is regulated using a short, strain-specific peptide pheromone. Growth conditions were shown to have considerable effects on the functionality of this regulatory mechanism.

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“…Table 6 summarizes some selected characteristics (for further information refer to de Vuyst & Vandamme, 1994;Holzapfel et al, 1995;Desmazeaud, 1994;Nes et al, 1996;Richard, 1996;Marshall & Tamime, 1997a).…”

Section: Bacteriocin Productionmentioning

confidence: 99%

Fermented milks: a historical food with modern applications–a review

2002

Eur J Clin Nutr

161

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Background: This paper was presented at the symposium which was organized by Instituto Danone Mexico in May 2001, and it provides an overview of the current scientific knowledge on fermented milks concerning the historical developments, manufacturing stages, classification of such products, and nutritional aspects. Particular attention has been paid to the human health benefits associated with the consumption of these products, the use of probiotic starter cultures and their industrial applications, and the significance of using a trained sensory panel for the evaluation of probiotic fermented milks made with different commercial blends of starter cultures. The paper also highlights the future research areas for the exploitation of starter microflora (Lactobacillus, Bifidobacterium and Enterococcus species) in fermented milk products. Conclusion: This review indicates that the complex metabolism of the starter cultures is well established; however, more information is still needed on specific microbial metabolites such as polymerization of milk sugars for the production of exopolysaccharides and the modification of the milk peptides and secretion of bacteriocins. More clinical studies are still required to establish the 'functional' health benefits of probiotic fermented milks to humans. Sponsorship: The visit to Mexico City was supported by Instituto Danone Mexico.

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Biosynthesis of bacteriocins in lactic acid bacteria

Cited by 244 publications

References 73 publications

A two-component signal-transduction cascade in Carnobacterium piscicola LV17B: two signaling peptides and one sensor-transmitter

A two-component signal-transduction cascade in Carnobacterium piscicola LV17B: two signaling peptides and one sensor-transmitter

Pheromone‐induced production of antimicrobial peptides in Lactobacillus

Fermented milks: a historical food with modern applications–a review

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