1997
DOI: 10.1016/s0040-4020(97)00015-x
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Biosynthesis of polyketide-terpenoid (meroterpenoid) metabolites andibenin B and andilesin A in Aspergillus variecolor

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Cited by 53 publications
(45 citation statements)
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“…[5,5- 2 H 2 ]-1-deoxy-D-xylulose was synthesized according to Meyer et al (2004), while [5,5- 2 H 2 ]-mevalonic acid lactone was prepared according to Simpson et al (1997). The spectral data of the synthesized compounds were in agreement with the data given in the original references.…”
Section: Methodssupporting
confidence: 70%
“…[5,5- 2 H 2 ]-1-deoxy-D-xylulose was synthesized according to Meyer et al (2004), while [5,5- 2 H 2 ]-mevalonic acid lactone was prepared according to Simpson et al (1997). The spectral data of the synthesized compounds were in agreement with the data given in the original references.…”
Section: Methodssupporting
confidence: 70%
“…Shamixhantone may be formed by cyclization of one of the emericellin isoprenylated chains. The biosynthesis of dehydroaustinol would involve a different mixed polyketide-terpenoid route, as has been demonstrated for the compound austin in Aspergillus ustus, which is derived from the polyketide dimethylorsellinate (49,51). Therefore, CfwA would be needed for the activation of at least two as-yet-unidentified PKSs involved in the biosynthesis of emericellin (and shamixhantone) and dehydroaustinol.…”
Section: Discussionmentioning
confidence: 93%
“…25-29 Several studies have concluded that all of these compounds were derived by alkylation of polyketide intermediate 3,5-dimethylorsellinate by the terpenoid precursor farnesyl pyrophosphate. 29 Berkeleyacetal C 5, berkeleydione 1 and berkeleytrione 2 inhibited both MMP-3 and caspase-1 in the micromolar range, while berkeleyacetals A and B inhibited these enzymes in the millimolar range. Only berkeleyacetal C was accepted in the NCI Developmental Therapeutics Program for human cell line screening and tested in the single dose response assay.…”
mentioning
confidence: 94%