Biosynthesis of polynucleotides. 5. The effect of adenine on the utilization of glucose for ribonucleic acid synthesis in <i>Candida utilis</i>

Barker, G. R.; Jechová, V.; Nicholson, Bruce H.; Thompson, J

doi:10.1042/bj0910322

Cited by 3 publications

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“…In a subsequent experiment, David & Renaut (1955) found that all the activity was located at C(1) of the ribose molecule. Thus there is some evidence that the oxidative pathway from glucose to ribose plays a major role in this organism, and this is in agreement with results presented by Barker et al (1964). In the present studies, an attempt has been made to investigate the part played by major and minor contributory processes, and their possible susceptibility to exogenous adenine.…”

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confidence: 92%

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Biosynthesis of polynucleotides. 6. The utilization of glucose in the synthesis of ribose in Candida utilis

Barker¹,

Nicholson²

1964

Biochemical Journal

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Addition of adenine to the culture medium results in a depression of the labelling of RNA in Candida utilis growing exponentially in the presence of radioactive glucose as the sole carbon source (Barker, Jechova, Nicholson & Thompson, 1964). Evidence suggests that the effect may be due in part to changes in the contribution of the various metabolic pathways concerned in ribose formation. The reactions involved in the formation of ribose in C. Utili8 have not been fully defined. Sowden

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confidence: 92%

“…of liquid medium, harvested and the cells were suspended in 600 ml. of fresh medium as described by Barker et al (1964). The cell suspension was divided equally between two flasks; 15 mg. of adenine dissolved in 1 ml.…”

Section: Resultsmentioning

confidence: 99%