Biosynthesis of Ribose and Deoxyribose

Sable, Henry Z.

doi:10.1002/9780470122730.ch7

Cited by 8 publications

(1 citation statement)

References 171 publications

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“…One component of this robustness is redundancy, which can be mediated by isoenzymes that perform the same catalytic reaction (David and Wiesmeyer 1970;Skinner and Cooper 1974;Primerano and Burns 1983), multiple pathways or routes that generate a particular metabolite (Sable 1966;Ramos et al 2008), and systems that maintain homeostasis of the cellular environment (Tokumoto and Takahashi 2001;Takahashi and Tokumoto 2002). It has been suggested that metabolic redundancies exist to safeguard vital cellular processes by providing overlapping levels of biological function (de Visser et al 2003), but there is increasing evidence that metabolic redundancy in a cell may be a signature of pathway evolution (Wang and Zhang 2009).…”

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confidence: 99%

Plasticity in the Purine–Thiamine Metabolic Network of Salmonella

Bazurto

Downs

2011

Genetics

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In Salmonella enterica, 5-aminoimidazole ribonucleotide (AIR) is the precursor of the 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP) pyrophosphate moiety of thiamine and the last intermediate in the common HMP/purine biosynthetic pathway. AIR is synthesized de novo via five reactions catalyzed by the purF, -D, -T, -G, and -I gene products. In vivo genetic analysis demonstrated that in the absence of these gene products AIR can be generated if (i) methionine and lysine are in the growth medium, (ii) PurC is functional, and (iii) 5-amino-4-imidazolecarboxamide ribotide (AICAR) has accumulated. This study provides evidence that the five steps of the common HMP/purine biosynthetic pathway can be bypassed in the synthesis of AIR and thus demonstrates that thiamine synthesis can be uncoupled from the early purine biosynthetic pathway in bacteria.

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