Biosynthesis of silver nanoparticles from Arum dioscoridis plant leaf aqueous extract: anticancer and antimicrobial properties

İpek, Polat; Baran, Mehmet Fırat; Yıldız, Reşit; Hatipoğlu, Abdulkerim

doi:10.31015/jaefs.2023.2.18

Cited by 4 publications

(1 citation statement)

References 58 publications

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“…5 Synthesis studies using plant sources for these methods attracted attention with advantages such as being cheap, being easy, not requiring special conditions to obtain the source, and showing biocompatible properties. 6,7 Plant parts used as supplies for synthesis include leaves, flowers, fruits, seeds, and roots. Extracts from plant sources are a rich source of phytochemicals.…”

Section: Introductionmentioning

confidence: 99%

Morus alba L. Leaves-Based Silver Nanoparticles for Aging-Related Infectious Diseases

Baran,

Meşe,

Eftekhari

2023

Int J Aging

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Objectives: One of the most common types of aging-related diseases is infection for which ample medications are available, and most antibacterial agents are ineffective as drug resistance spreads globally. Design: An original study. Setting(s): Batman University, Batman, Turkiye. Outcome measures: The presence of silver nanoparticles was analyzed with their maximum wavelength absorbance. Morphological appearances and distributions of synthesized nanoparticles were evaluated using transmissive electron microscope (TEM) and atomic power microscopy, respectively. The crystal patterns and sizes of nanoparticles were determined using an X-ray diffraction (XRD) instrument, and the crystal nanosizes were calculated by the DebyeScherrer equation. Minimum inhibition concentrations (MICs) were used for identifying an antibacterial effect on Gram-positive and Gram-negative strains of the bacteria Staphylococcus aureus ATCC 29213 and Escherichia coli ATCC 25922. Results: The Malatya Orduzu region provided the leaves of the Morus alba L. plant used in this study. The resulting extract was used to create silver nanoparticles. The outcomes of several microscopic and spectroscopic analyses were used to evaluate the properties of silver nanoparticles. Conclusions: Morus alba L. leaves were used to create silver nanoparticles (Ma-AgNPs), which had a size distribution below 100 nm and a maximum absorbance of 457.92 nm. Ma-AgNP’s antibacterial activity was used for pathogen gram-positive and gram-negative bacteria.

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Section: Introductionmentioning

confidence: 99%

Morus alba L. Leaves-Based Silver Nanoparticles for Aging-Related Infectious Diseases

Baran,

Meşe,

Eftekhari

2023

Int J Aging

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Impact of metallic nanoparticles on gut microbiota modulation in colorectal cancer: A review

Kumar,

Pramanik,

Batta

et al. 2024

Cancer Innovation

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Colorectal cancer (CRC) is the third most prevalent cancer. Ongoing research aims to uncover the causes of CRC, with a growing focus on the role of gut microbiota (GM) in carcinogenesis. The GM influences CRC development, progression, treatment efficacy, and therapeutic toxicities. For example, Fusobacterium nucleatum and Escherichia coli can regulate microbial gene expression through the incorporation of human small noncode RNA and potentially contribute to cancer progression. Metallic nanoparticles (MNPs) have both negative and positive impacts on GM, depending on their type. Several studies state that titanium dioxide may increase the diversity, richness, and abundance of probiotics bacteria, whereas other studies demonstrate dose‐dependent GM dysbiosis. The MNPs offer cytotoxicity through the modulation of MAPK signaling pathways, NF‐kB signaling pathways, PI3K/Akt signaling pathways, extrinsic signaling pathways, intrinsic apoptosis, and cell cycle arrest at G1, G2, or M phase. MNPs enhance drug delivery, enable targeted therapy, and may restore GM. However, there is a need to conduct well‐designed clinical trials to assess the toxicity, safety, and effectiveness of MNPs‐based CRC therapies.

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Anticancer Activities of Zinc Oxide Nanoparticles (ZnONPs) Synthesized from Mentha longifolia L. Leaf Extract

İPEK,

BARAN,

HATİPOĞLU

et al. 2024

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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Recently, there has been a remarkable increase in cancer and cancer-related deaths. In this study, the impacts of zinc oxide nanoparticles (ZnONPs) produced from the aqueous leaf extract of Mentha longifolia L. (ML) on ovary adenocarcinoma (OVCAR-3), colorectal carcinoma (HCT-116), and healthy retinal pigment epithelial cell (RPE-1) lines were investigated. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) test was performed to discover its antiproliferative properties. As a result of the application of ML-ZnONPs on RPE-1, OVCAR-3, and HCT-116 cell lines at doses (µg/mL) of 250, 500, and 1000 for 24 hours, the viability rates (%) in the cell lines were 18.73-30.56, 21.98-28.76, and 27.27-40.93, respectively. In the 48-hour application, the viability rates (%) of the same cells were between 29.51-46.83, 32.49-40.81, and 46.82-44.37, respectively. The MTT test revealed that ML-ZnONPs strongly suppressed the growth of RPE-1, OVCAR-3, and HCT-116 cell lines. The test showed that the effect of dose increase and time on the viability of both cancer cell lines was negative.

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Biosynthesis of silver nanoparticles from Arum dioscoridis plant leaf aqueous extract: anticancer and antimicrobial properties

Cited by 4 publications

References 58 publications

Morus alba L. Leaves-Based Silver Nanoparticles for Aging-Related Infectious Diseases

Morus alba L. Leaves-Based Silver Nanoparticles for Aging-Related Infectious Diseases

Impact of metallic nanoparticles on gut microbiota modulation in colorectal cancer: A review

Anticancer Activities of Zinc Oxide Nanoparticles (ZnONPs) Synthesized from Mentha longifolia L. Leaf Extract

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