Biosynthesis of Violacein: Origins of Hydrogen, Nitrogen and Oxygen Atoms in the 2-Pyrrolidone Nucleus

Hoshino, Tsutomu; Takano, Tsuyoshi; Hori, Shigeki; Ogasawara, Nagahiro

doi:10.1080/00021369.1987.10868447

Cited by 11 publications

(18 citation statements)

References 7 publications

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“…Efforts were made to study the biosynthetic pathway of violacein from C. violaceum through studying of the role of tryptophan and other indol derivates in the stimulation of violacein biosynthesis (Hoshino et al . 1987a,b; Hoshino and Ogasawara 1990; Durán et al .…”

Section: Discussionmentioning

confidence: 99%

Effect of agitation on violacein production in Pseudoalteromonas luteoviolacea isolated from a marine sponge

Yang

Xiong

Lee

et al. 2007

Lett Appl Microbiol

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Aims: Experiments were designed to investigate the effect of agitation on the production of violacein by a marine bacterium Pseudoalteromonas luteoviolacea. Methods and Results: A marine sponge‐associated bacterium, P. luteoviolacea, was grown at different agitation speeds. Agitation did not have a significant effect on bacterial growth, but had a profound effect on the size of bacterial aggregate. The production of violacein was the highest under stagnant conditions and decreased with the increase of the agitation speed. Conclusions: Agitation affected the aggregation of bacterial cells, which, in turn, affected violacein production by P. luteoviolacea. Significance and Impact of the Study: This study suggests that P. luteoviolacea produced the highest amount of violacein when it was cultured under stagnant conditions.

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Section: Discussionmentioning

confidence: 99%

Effect of agitation on violacein production in Pseudoalteromonas luteoviolacea isolated from a marine sponge

Yang

Xiong

Lee

et al. 2007

Lett Appl Microbiol

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“…The strain was not haemolytic on sheep blood. In the presence of oxygen, the strain was found to produce a violet pigment, matching the spectral and solubility properties of violacein (Hoshino et al, 1987).…”

Section: Phenotypic Characterizationmentioning

confidence: 81%

“…Preliminary characterization, including positive protease and lecithinase activity and deep-violet colonies on nutrient agar, suggested that it was a member of the genus Chromobacterium (Gillis & Logan, 2005) rather than Janthinobacterium, another genus that contains species which produce violet pigment. Chromobacterium violaceum, the type species of the genus, produces a violet pigment, violacein (Hoshino et al, 1987), synthesis of which is controlled by quorum sensing (McClean et al, 1997). Violacein has been described as a trypanocide and having antibiotic properties (Durán et al, 1994).…”

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confidence: 99%

Chromobacterium subtsugae sp. nov., a betaproteobacterium toxic to Colorado potato beetle and other insect pests

Martin

Gundersen‐Rindal

Blackburn

et al. 2007

International Journal of Systematic and Evolutionary Microbiology

123

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Strain PRAA4-1T, a motile, Gram-negative, violet-pigmented bacterium, was isolated from Maryland forest soil and found to be orally toxic to Colorado potato beetle larvae and other insects. Morphological, biological, biochemical and molecular characterization revealed that this strain was most similar to Chromobacterium violaceum, the type species and only currently recognized member of the genus Chromobacterium. DNA–DNA hybridization with C. violaceum ATCC 12472T was 27 %. Phylogenetic analysis of 16S rRNA gene sequences revealed that strain PRAA4-1T and Chromobacterium violaceum form a monophyletic clade, with the closest ancestral taxon Vogesella indigofera within the Betaproteobacteria. On the basis of phenotypic, genotypic and phylogenetic analyses, strain PRAA4-1T (=NRRL B-30655T=DSM 17043T) is proposed as the type strain of a novel species of the genus Chromobacterium, Chromobacterium subtsugae sp. nov.

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“…This compound is, probably, synthetized via condensation of the lateral chain of two tryptophan molecules (3,4). Although violacein has antibacterial (5,6), antitumor (4,7), anti-viral (8) antimicobacterial (9) and antileishmanial activities (10), it has hightoxicity for mammal cells (11).…”

Section: Introductionmentioning

confidence: 99%

The use of violacein to study biochemical behaviour ofSaccharomyces cerevisiae cells

Pereira

Volpe

2005

European Journal of Drug Metabolism and Pharmacokinetics

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Violacein, a biochemical compound produced by Chromobacterium violaceum which has antichagasic properties, was used to study biochemical behaviour of Saccharomyces cerevisiae cells. At 20 microM and 40 microM, violacein did not alter the membrane potential (deltapsi) of S. cerevisae cells, which means that the integrity of the cell membrane was maintained. On the other hand, at 60 microM and 80 microM, violacein produced significant alterations in the membrane potential. This information will be very useful in using S. cerevisiae cells as a model to test the toxicity of new drugs before using in animals or human beings.

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Biosynthesis of Violacein: Origins of Hydrogen, Nitrogen and Oxygen Atoms in the 2-Pyrrolidone Nucleus

Cited by 11 publications

References 7 publications

Effect of agitation on violacein production in Pseudoalteromonas luteoviolacea isolated from a marine sponge

Effect of agitation on violacein production in Pseudoalteromonas luteoviolacea isolated from a marine sponge

Chromobacterium subtsugae sp. nov., a betaproteobacterium toxic to Colorado potato beetle and other insect pests

The use of violacein to study biochemical behaviour ofSaccharomyces cerevisiae cells

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