Biotech nanocellulose: A review on progress in product design and today’s state of technical and medical applications

Klemm, Dieter; Petzold‐Welcke, Katrin; Krämer, Friederike; Richter, T.; Raddatz, Vanessa; Fried, Wolfgang; Nietzsche, Sándor; Bellmann, Tom; Fischer, Dagmar

doi:10.1016/j.carbpol.2020.117313

Cited by 44 publications

(56 citation statements)

References 95 publications

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“…The BNC grafts with an inner diameter of 5.0 mm were produced in a standardized fashion as described before [ 36 , 37 , 38 ]. Briefly, in a customized bioreactor, cylindrical templates made of bamboo with a diameter of 5.0 mm were moved periodically between air space and a reservoir, which was filled with liquid culture medium and bacteria of the genus Komagataeibacter xylinus (German Collection of Microorganisms and Cell Cultures GmbH, DSM 32384).…”

Section: Methodsmentioning

confidence: 99%

Comparative Evaluation on Impacts of Fibronectin, Heparin–Chitosan, and Albumin Coating of Bacterial Nanocellulose Small-Diameter Vascular Grafts on Endothelialization In Vitro

et al. 2021

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In this study, we contrast the impacts of surface coating bacterial nanocellulose small-diameter vascular grafts (BNC-SDVGs) with human albumin, fibronectin, or heparin–chitosan upon endothelialization with human saphenous vein endothelial cells (VEC) or endothelial progenitor cells (EPC) in vitro. In one scenario, coated grafts were cut into 2D circular patches for static colonization of a defined inner surface area; in another scenario, they were mounted on a customized bioreactor and subsequently perfused for cell seeding. We evaluated the colonization by emerging metabolic activity and the preservation of endothelial functionality by water soluble tetrazolium salts (WST-1), acetylated low-density lipoprotein (AcLDL) uptake assays, and immune fluorescence staining. Uncoated BNC scaffolds served as controls. The fibronectin coating significantly promoted adhesion and growth of VECs and EPCs, while albumin only promoted adhesion of VECs, but here, the cells were functionally impaired as indicated by missing AcLDL uptake. The heparin–chitosan coating led to significantly improved adhesion of EPCs, but not VECs. In summary, both fibronectin and heparin–chitosan coatings could beneficially impact the endothelialization of BNC-SDVGs and might therefore represent promising approaches to help improve the longevity and reduce the thrombogenicity of BNC-SDVGs in the future.

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Section: Methodsmentioning

confidence: 99%

Comparative Evaluation on Impacts of Fibronectin, Heparin–Chitosan, and Albumin Coating of Bacterial Nanocellulose Small-Diameter Vascular Grafts on Endothelialization In Vitro

et al. 2021

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“…Bacterial nanocellulose can also conform hydrogel tubes with multi-layered structure with the possibility of containing additives. Tubular nanocellulose can be used for cardiovascular implants as well as restorative material to repair areas of the bile duct, ureter and esophagus [110]. Some specific modifications of BNC have resulted in the production of compounds that can be substitutes for cartilage of the meniscus, auricular and nasal concha or even tubes for the regeneration of the nerves.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Nanocellulose from Agricultural Wastes: Products and Applications—A Review

et al. 2021

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The isolation of nanocellulose from different agricultural residues is becoming an important research field due to its versatile applications. This work collects different production processes, including conditioning steps, pretreatments, bleaching processes and finally purification for the production of nanocellulose in its main types of morphologies: cellulose nanofiber (CNF) and cellulose nanocrystal (CNC). This review highlights the importance of agricultural wastes in the production of nanocellulose in order to reduce environmental impact, use of fossil resources, guarantee sustainable economic growth and close the circle of resource use. Finally, the possible applications of the nanocellulose obtained as a new source of raw material in various industrial fields are discussed.

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“…[ 1,2 ] Cellulose is the most abundant natural renewable biopolymer on earth [ 3 ] and has good biosafety. [ 4,5 ] Due to its inherent advantages, compared with synthetic materials, it has attracted increasingly attention in the field of biology [ 6,7 ] and medicine. [ 8,9 ] However, many problems still need to be solved if cellulose is used as a raw material for wound dressings, [ 10–12 ] such as low mechanical strength leading to low durability of the material, difficulty in uniform dispersing of hydrophobic drugs in the hydrophilic cellulose matrix, and higher swelling rate making it compressive to the wound.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Cellulose Hydrogel Dressing with Evenly Dispersed Hydrophobic Drugs by Hydrogen Bonding and Encapsulation Methods

Wang

Jiang

et al. 2021

Macro Materials & Eng

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A transparent cellulose‐based functional hydrogel dressing is prepared by hydrogen bonding interaction and encapsulation technique, which can uniformly disperse hydrophobic drugs and has the advantages of simple preparation, good biocompatibility, fast self‐healing ability, and slow drug release. Menthol, which is insoluble and irritating, is used as a model drug, encapsulated by ethylenediamine‐modified cyclodextrin, and then loaded onto a hydrogel dressing. The introduction of modified cyclodextrin not only improves the stability and solubility of menthol, but also makes the hydrophobic menthol uniformly dispersed in hydrophilic hydrogel dressing, and the large amount of hydrogen bonding can enable rapid hydrogel generation. In addition, the microstructure, swelling, biocompatibility and drug loading properties of the hydrogel are investigated, and the results show that the hydrogel has good prospects for application in the field of wound dressings.

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Biotech nanocellulose: A review on progress in product design and today’s state of technical and medical applications

Cited by 44 publications

References 95 publications

Comparative Evaluation on Impacts of Fibronectin, Heparin–Chitosan, and Albumin Coating of Bacterial Nanocellulose Small-Diameter Vascular Grafts on Endothelialization In Vitro

Comparative Evaluation on Impacts of Fibronectin, Heparin–Chitosan, and Albumin Coating of Bacterial Nanocellulose Small-Diameter Vascular Grafts on Endothelialization In Vitro

Nanocellulose from Agricultural Wastes: Products and Applications—A Review

Preparation of Cellulose Hydrogel Dressing with Evenly Dispersed Hydrophobic Drugs by Hydrogen Bonding and Encapsulation Methods

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