Biotechnological Applications of Scyphomedusae

Merquiol, Louise; Romano, Giovanna; Ianora, Adrianna; D’Ambra, Isabella

doi:10.3390/md17110604

Cited by 38 publications

(81 citation statements)

References 152 publications

(96 reference statements)

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“…However, as reported by [ 11 , 16 ], receptor site three has been identified as the binding site for sea anemone Type I and Type III sodium channel inhibitors. Toxins have been recently reviewed in Scyphozoa [ 13 , 14 , 17 ] and in sea anemones (Actinaria) [ 11 , 14 ]. In this review, we provide an updated synopsis of the main compounds identified to present in the venom of cnidarians and discuss the recent application of omics and biotechnological tools in the field.…”

Section: Venoms Of Cnidariamentioning

confidence: 99%

“…The crude venom extracted from cnidarians has a wide range of effects on humans, such as dermonecrosis, edema, diffused neurotoxicity, motorial and respiratory problems, cardiovascular symptoms, hypotension and occasionally death [ 17 ]. Cytotoxic, cytolytic, hemolytic and neurotoxic activities are the most common effects observed for crude Cnidaria venom ( Table 2 ).…”

Section: Cnidaria Bioprospectingmentioning

confidence: 99%

“…In addition to these therapeutic possible applications, it is important to remind the reader that various Cnidaria species, mainly scyphomedusae, are a common ingredient in the Eastern cooking tradition and suggested in Western countries as an alternative/integrative source of food thanks to their rich composition of proteins and fatty acids (see review of Merquiol et al [ 17 ]). Scyphomedusae have been also suggested as providing a contribution to the cosmeceutical and biomaterial industries (for more details, see the reviews by [ 17 , 209 ]). However, at present these remain potential biotechnological applications that still need to be developed.…”

Section: Cnidaria Bioprospectingmentioning

confidence: 99%

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A Review of Toxins from Cnidaria

D’Ambra

Lauritano

2020

Marine Drugs

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Cnidarians have been known since ancient times for the painful stings they induce to humans. The effects of the stings range from skin irritation to cardiotoxicity and can result in death of human beings. The noxious effects of cnidarian venoms have stimulated the definition of their composition and their activity. Despite this interest, only a limited number of compounds extracted from cnidarian venoms have been identified and defined in detail. Venoms extracted from Anthozoa are likely the most studied, while venoms from Cubozoa attract research interests due to their lethal effects on humans. The investigation of cnidarian venoms has benefited in very recent times by the application of omics approaches. In this review, we propose an updated synopsis of the toxins identified in the venoms of the main classes of Cnidaria (Hydrozoa, Scyphozoa, Cubozoa, Staurozoa and Anthozoa). We have attempted to consider most of the available information, including a summary of the most recent results from omics and biotechnological studies, with the aim to define the state of the art in the field and provide a background for future research.

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Section: Venoms Of Cnidariamentioning

confidence: 99%

Section: Cnidaria Bioprospectingmentioning

confidence: 99%

Section: Cnidaria Bioprospectingmentioning

confidence: 99%

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A Review of Toxins from Cnidaria

D’Ambra

Lauritano

2020

Marine Drugs

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“…A recent review has shown that rhizostome scyphomedusae contain more collagen than semaeostomeae scyphomedusae [51], as shown in Table 1. The collagen content in Rhopilema esculentum is significantly high, considering that the value in Table 1 is based on dry mass.…”

Section: Introductionmentioning

confidence: 99%

Marine Collagen from Alternative and Sustainable Sources: Extraction, Processing and Applications

et al. 2020

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Due to its unique properties, collagen is used in the growing fields of pharmaceutical and biomedical devices, as well as in the fields of nutraceuticals, cosmeceuticals, food and beverages. Collagen also represents a valid resource for bioplastics and biomaterials, to be used in the emerging health sectors. Recently, marine organisms have been considered as promising sources of collagen, because they do not harbor transmissible disease. In particular, fish biomass as well as by-catch organisms, such as undersized fish, jellyfish, sharks, starfish, and sponges, possess a very high collagen content. The use of discarded and underused biomass could contribute to the development of a sustainable process for collagen extraction, with a significantly reduced environmental impact. This addresses the European zero-waste strategy, which supports all three generally accepted goals of sustainability: sustainable economic well-being, environmental protection, and social well-being. A zero-waste strategy would use far fewer new raw materials and send no waste materials to landfills. In this review, we present an overview of the studies carried out on collagen obtained from by-catch organisms and fish wastes. Additionally, we discuss novel technologies based on thermoplastic processes that could be applied, likewise, as marine collagen treatment.2 of 23 protective colloid functions and film-forming capacity. Also, collagen is a good surface-active agent, with its ability to penetrate lipid-free interfaces [2].Collagen can be utilized in a variety of applications because of its biocompatibility and excellent degradability [3,4]. Furthermore, it is known that collagen is a molecule with weak immunogenicity, which decreases the possibilities of rejection when it is ingested or injected into a different body. Although this molecule has already low antigenicity, this property can be enhanced by modifying it to suppress any immune response [5,6]. Additionally, collagen peptides and gelatin (denatured collagen) have been widely utilized in different fields such as food, medicine, cosmetics, leather and film industries, diagnostic imaging, and therapeutic delivery [7].For many years, most available collagen was extracted from discards from the bovine and porcine processing industries, but during the last few decades the use of collagen from these sources has been limited. The use of porcine and bovine-derived products is occasionally prevented by dietary regimes, due to specific needs or personal choices. It is forbidden by religious constraints, to Muslims, Hindus and Jews who make up 38.4% of the global population [8]. Moreover, the use of bovine-derived products became a concern for a wider section of the population during the bovine spongiform encephalopathy (BSE), transmissible spongiform encephalopathy (TSE) and foot-and-mouth disease (FMD) crises that occurred over the last few decades in all areas of the world, mostly in the United Kingdom and Asia. Bovine-derived products might be a vehicle of transmission of these diseases ...

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“…Jellyfish extracted molecules (proteins, peptides, mucins) have antioxidant, wound healing and antimicrobial properties (Merquiol et al, 2019;Nudelman et al, 2019). The most famous jellyfish-derived compound is the green fluorescent protein (GFP), one of the most important tools in molecular biology research, serving as a molecular marker alongside other that found important applications in wider scientific research, and was awarded the Nobel Prize in Chemistry in 2008 to Osamu Shimomura, Martin Chalfie, and Roger Tsien.…”

Section: Potential Future Prospects In Healthcare and Well-beingmentioning

confidence: 99%

The Essentials of Marine Biotechnology

Barbier²,

et al. 2021

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Coastal countries have traditionally relied on the existing marine resources (e.g., fishing, food, transport, recreation, and tourism) as well as tried to support new economic endeavors (ocean energy, desalination for water supply, and seabed mining). Modern societies and lifestyle resulted in an increased demand for dietary diversity, better health and well-being, new biomedicines, natural cosmeceuticals, environmental conservation, and sustainable energy sources. These societal needs stimulated the interest of researchers on the diverse and underexplored marine environments as promising and sustainable sources of biomolecules and biomass, and they are addressed by the emerging field of marine (blue) biotechnology. Blue biotechnology provides opportunities for a wide range of initiatives of commercial interest for the pharmaceutical, biomedical, cosmetic, nutraceutical, food, feed, agricultural, and related industries. This article synthesizes the essence, opportunities, responsibilities, and challenges encountered in marine biotechnology and outlines the attainment and valorization of directly derived or bio-inspired products from marine organisms. First, the concept of bioeconomy is introduced. Then, the diversity of marine bioresources including an overview of the most prominent marine organisms and their potential for biotechnological uses are described. This is followed by introducing methodologies for exploration of these resources and the main use case scenarios in energy, food and feed, agronomy, bioremediation and climate change, cosmeceuticals, bio-inspired materials, healthcare, and well-being sectors. The key aspects in the fields of legislation and funding are provided, with the emphasis on the importance of communication and stakeholder engagement at all levels of biotechnology development. Finally, vital overarching concepts, such as the quadruple helix and Responsible Research and Innovation principle are highlighted as important to follow within the marine biotechnology field. The authors of this review are collaborating under the European Commission-funded Cooperation in Science and Technology (COST) Action Ocean4Biotech – European transdisciplinary networking platform for marine biotechnology and focus the study on the European state of affairs.

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Biotechnological Applications of Scyphomedusae

Cited by 38 publications

References 152 publications

A Review of Toxins from Cnidaria

A Review of Toxins from Cnidaria

Marine Collagen from Alternative and Sustainable Sources: Extraction, Processing and Applications

The Essentials of Marine Biotechnology

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