Biotechnological Exploitation of Actinobacterial Members

Hamedi, Javad; Mohammadipanah, Fatemeh; Panahi, Hamed Kazemi Shariat

doi:10.1007/978-3-319-14595-2_3

Cited by 18 publications

(8 citation statements)

References 524 publications

(227 reference statements)

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“…Microorganisms are capable of producing a wide range of metabolites from antibiotics, [1][2][3] pigments, 4 and vitamins, to antioxidants, 5,6 enzymes, 7 and toxins. 8 They can exert positive or negative effects through the production of some of these metabolites when they live in the human body as microbiota.…”

Section: Introductionmentioning

confidence: 99%

Microorganisms, Tryptophan Metabolism, and Kynurenine Pathway: A Complex Interconnected Loop Influencing Human Health Status

Dehhaghi

Panahi

Guillemin

2019

Int J�Tryptophan�Res

158

122

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The kynurenine pathway is important in cellular energy generation and limiting cellular ageing as it degrades about 90% of dietary tryptophan into the essential co-factor NAD+ (nicotinamide adenine dinucleotide). Prior to the production of NAD+, various intermediate compounds with neuroactivity (kynurenic acid, quinolinic acid) or antioxidant activity (3-hydroxykynurenine, picolinic acid) are synthesized. The kynurenine metabolites can participate in numerous neurodegenerative disorders (Alzheimer disease, amyotrophic lateral sclerosis, Huntington disease, and Parkinson disease) or other diseases such as AIDS, cancer, cardiovascular diseases, inflammation, and irritable bowel syndrome. Recently, the role of gut in affecting the emotional and cognitive centres of the brain has attracted a great deal of attention. In this review, we focus on the bidirectional communication between the gut and the brain, known as the gut-brain axis. The interaction of components of this axis, namely, the gut, its microbiota, and gut pathogens; tryptophan; the kynurenine pathway on tryptophan availability; the regulation of kynurenine metabolite concentration; and diversity and population of gut microbiota, has been considered.

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Section: Introductionmentioning

confidence: 99%

Microorganisms, Tryptophan Metabolism, and Kynurenine Pathway: A Complex Interconnected Loop Influencing Human Health Status

Dehhaghi

Panahi

Guillemin

2019

Int J�Tryptophan�Res

158

122

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“…The second phylum of this study Actinobacteria was recovered from both soil and root of the sea grass. Actinobacteria both in terrestrial and marine environment are rich source of antibiotic production and are resistant to different fungal and bacterial pathogens (Manivasagan et al 2014;Hamedi et al 2015). In this study, most of the Actinobacteria were isolated from roots of the sea grass.…”

Section: Discussionmentioning

confidence: 95%

Diversity and antagonistic potential of bacteria isolated from marine grass Halodule uninervis

et al. 2018

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The aim of this study was to isolate bacteria from sea grass, Halodule uninervis collected from the coastal area of Jeddah, Saudi Arabia and to screen them for antifungal and enzymatic activities. We have isolated 162 rhizo and endophytic bacteria from soil, roots, and leaves of the sea grass. Antifungal screening of isolated bacteria revealed 19 strains (11.7%) capable to inhibit growth of four pathogenic fungi, Pythium ultimum, Phytophthora capsici, pyricularia oryzae, and Rhizoctonia solani in an in vitro assay. Taxonomic and phylogenetic analyses on the basis of 16S rRNA gene sequence revealed 97-99.9% sequence identity to recognized species. Bacillus, Staphylococcus, Jeotgalicoccus, and Planococcus, within the Phylum Firmicutes, Kocuria, Arthrobacter, Ornithinimicrobium and Corynebacterium (Actinobacteria), Sulfitobacter, Roseivivax, Ruegeria (α-Proteobacteria), Moraxella, and Vibrio (γ-Proteobacteria), were isolated. Strains belong to Phylum Firmicutes remain dominant antagonistic bacteria in this study. Further hydrolytic enzyme production was determined for these antagonistic bacteria. Our results demonstrated that the sea grass represents an important source of diverse antagonistic bacteria capable of producing antifungal metabolite.

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“…Microorganisms occur ubiquitously and have abilities to metabolize a diverse range of metabolites ranging from enzymes (Hamedi et al, 2015;Mohammadipanah et al, 2015), therapeutic lead compounds (Mohammadipanah et al, 2016;Sajedi et al, 2018), and antioxidants (Dehhaghi et al, 2018b(Dehhaghi et al, , 2019a(Dehhaghi et al, ,c, 2020 to hydrocarbon-rich compounds, i.e., ethanol (Dehhaghi et al, 2019a;Kazemi Shariat Panahi et al, 2019b), butanol (Dehhaghi et al, 2019b), and methane (Dehhaghi et al, 2019b;Tabatabaei et al, 2019).…”

Section: The Gut Microbiota-brain Axismentioning

confidence: 99%

The Gut Microbiota, Kynurenine Pathway, and Immune System Interaction in the Development of Brain Cancer

Dehhaghi

Panahi

Heng

et al. 2020

Front. Cell Dev. Biol.

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Human gut microbiota contains a large, complex, dynamic microbial community of approximately 10 14 microbes from more than 1,000 microbial species, i.e., equivalent to 4 × 10 6 genes. Numerous evidence links gut microbiota with human health and diseases. Importantly, gut microbiota is involved in the development and function of the brain through a bidirectional pathway termed as the gut-brain axis. Interaction between gut microbiota and immune responses can modulate the development of neuroinflammation and cancer diseases in the brain. With respect of brain cancer, gut microbiota could modify the levels of antioxidants, amyloid protein and lipopolysaccharides, arginase 1, arginine, cytochrome C, granulocytemacrophage colony-stimulating factor signaling (GM-CSF), IL-4, IL-6, IL-13, IL-17A, interferon gamma (IFN-γ), reactive oxygen species (ROS), reactive nitrogen species (e.g., nitric oxide and peroxynitrite), short-chain fatty acids (SCFAs), tryptophan, and tumor necrosis factor-β (TGF-β). Through these modifications, gut microbiota can modulate apoptosis, the aryl hydrocarbon receptor (AhR), autophagy, caspases activation, DNA integrity, microglia dysbiosis, mitochondria permeability, T-cell proliferation and functions, the signal transducer and activator of transcription (STAT) pathways, and tumor cell proliferation and metastasis. The outcome of such interventions could be either oncolytic or oncogenic. This review scrutinizes the oncogenic and oncolytic effects of gut microbiota by classifying the modification mechanisms into (i) amino acid deprivation (arginine and tryptophan); (ii) kynurenine pathway; (iii) microglia dysbiosis; and (iv) myeloid-derived suppressor cells (MDSCs). By delineating the complexity of the gutmicrobiota-brain-cancer axis, this review aims to help the research on the development of novel therapeutic strategies that may aid the efficient eradication of brain cancers.

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Biotechnological Exploitation of Actinobacterial Members

Cited by 18 publications

References 524 publications

Microorganisms, Tryptophan Metabolism, and Kynurenine Pathway: A Complex Interconnected Loop Influencing Human Health Status

Microorganisms, Tryptophan Metabolism, and Kynurenine Pathway: A Complex Interconnected Loop Influencing Human Health Status

Diversity and antagonistic potential of bacteria isolated from marine grass Halodule uninervis

The Gut Microbiota, Kynurenine Pathway, and Immune System Interaction in the Development of Brain Cancer

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