Biotechnological value of Moringa oleifera seed cake as source of insecticidal lectin against Aedes aegypti

Oliveira, Ana Patrícia Silva de; Silva, Livia Lais de Santana; Lima, Thâmarah de Albuquerque; Pontual, Emmanuel Viana; Santos, Nataly Diniz de Lima; Coelho, Luana Cassandra Breitenbach Barroso; Navarro, Daniela Maria do Amaral Ferraz; Zingali, Russolina B.; Napoleão, Thiago Henrique; Paiva, Patrícia Maria Guedes

doi:10.1016/j.procbio.2016.06.026

Cited by 25 publications

(11 citation statements)

References 44 publications

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“…Similarly, WSMoL stimulates the protease, trypsin‐like, and α‐amylase activities from A. aegypti larvae . WSMoL C , a lectin isolated from the seed cake of M. oleifera , also stimulated the gut activities of protease and α‐amylase from A. aegypti larvae . Exoglucanase, α‐ l ‐arabinofuranosidase, amylase, and trypsin‐like activities from gut extracts of N. corniger workers were also affected when incubated with MuBL or MuLL; the ability of MuBL to bind trypsin‐like enzymes from the termite gut was corroborated by lectin affinity chromatography .…”

Section: Targets and Insecticidal Effects Of Lectinsmentioning

confidence: 97%

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Insect midgut structures and molecules as targets of plant‐derived protease inhibitors and lectins

Napoleão

Albuquerque

Santos

et al. 2018

Pest Management Science

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The midgut of insects is involved in digestion, osmoregulation and immunity. Although several defensive strategies are present in this organ, its organization and function may be disturbed by some insecticidal agents, including bioactive proteins like lectins and protease inhibitors (PIs) from plants. PIs interfere with digestion, leading to poor nutrient absorption and decreasing amino acid bioavailability. Intake of PIs can delay development, cause deformities and reduce fertility. Ingestion of PIs may lead to changes in the set of proteases secreted in the insect gut, but this response is often insufficient and results in aggravation of the malnutrition status. Lectins are proteins that are able to interact with glycoconjugates, including those linked to cell surfaces. Their effects on the midgut include disruption of the peritrophic matrix, brush border and secretory cell layer; induction of apoptosis and oxidative stress; interference with nutrient absorption and transport proteins; and damaging effects on symbionts. In addition, lectins can cross the intestinal barrier and reach the hemolymph. The establishment of resistant insect populations due to selective pressure resulting from massive use of a bioactive protein is an actual possibility, but this can be minimized by the multiple mode-of-action of these proteins, mainly the lectins.

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Section: Targets and Insecticidal Effects Of Lectinsmentioning

confidence: 97%

“…When ingested, lectins may cause insect mortality, impair growth, development and/or metamorphosis, and reduce feeding activity . These proteins can also be active on non‐feeding stages of development (eggs and pupae) and promote changes in behavior during oviposition …”

Section: Targets and Insecticidal Effects Of Lectinsmentioning

confidence: 99%

Insect midgut structures and molecules as targets of plant‐derived protease inhibitors and lectins

Napoleão

Albuquerque

Santos

et al. 2018

Pest Management Science

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“…However, because of its carbohydrate interactions, lectins have been tested for several biological functions, getting interesting results in some of them. Biological activities are related to immunomodulatory and antitumor [17][18][19], antifungal [20][21][22][23], antiparasitic [24][25][26], antiproliferative [27][28][29][30], healing process [31][32][33], drug delivery [34][35][36], as histochemical markers [37][38][39], biosensors [40,41], insecticide [42][43][44][45][46], etc.…”

Section: Structure and Biological Activities Of Plant Lectinsmentioning

confidence: 99%

Plant Lectins with Insecticidal and Insectistatic Activities

Reyes-Montaño¹,

Castro²

2018

Insecticides - Agriculture and Toxicology

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Lectins are an important group of proteins which are spread in all kingdoms of life. Their most lighted characteristic is associated to their specific carbohydrate binding, although function has been not even identified. According to their carbohydrate specificity, several biological activities have been assessed, finding that lectins can be used as mitogenic agents, biomarkers, and cytotoxic and insecticide proteins. Lectins have been classified according to several features such as structure, source, and carbohydrate recognition. The Protein Research Group (PRG) has worked on Colombian seeds from the family of Fabaceae and Lamiaceae plants, isolating and characterizing their lectins, and found more than one lectin in some plants, indicating that according to its specificity, different lectins can have different biological activities. In the case of legume domain lectins, they have shown the biggest potential as insecticide or insectistatic agents due to the glycosylation pattern in insect midgut cells. This review attempts to identify the characteristics of plant legume lectin domains that determine their insecticidal and insectistatic activities.

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“…Recently, the insecticidal properties of seeds against the Aedes aegypti mosquito have been researched [66].…”

Section: C) Desinfectant: Antibacterial Fungicides and Insecticides mentioning

confidence: 99%

Natural coagulants: analysis of potential use for drinking water treatment in developed and developing countries

García-Fayos¹,

Arnal²,

Sancho³

2018

dwt

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a b s t r a c tDrinking water must be colorless, odorless and tasteless, and free of substances or micro-organisms that can cause disease. The process to obtain drinking water is purification, understood as the treatment to make water suitable for human consumption. Water purification is traditionally composed of a sequence of standard treatments including coagulation-flocculation, sedimentation, filtration, and disinfection. Some compounds named coagulants are used for coagulation-flocculation, which is the stage in which the suspended matter is removed and the water is clarified. Coagulants are usually synthetic, therefore represent a high cost and are difficult to gets in some areas, especially in developing countries. In addition, their use is being revised and restricted in different international standards, in order to control or prohibit its use because of the possible hazard effects that the remains of these products in treated water can cause to people. In contrast to synthetic coagulants, there are several natural compounds with coagulation properties which have some advantages such as easy availability and safety. At present, scientific community is paying more attention to natural coagulants as legal restrictions to synthetic ones are becoming more severe. This paper is a review of natural coagulants as an alternative to chemical coagulants, in which their potential application in the treatment of drinking water is analysed.

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Biotechnological value of Moringa oleifera seed cake as source of insecticidal lectin against Aedes aegypti

Cited by 25 publications

References 44 publications

Insect midgut structures and molecules as targets of plant‐derived protease inhibitors and lectins

Insect midgut structures and molecules as targets of plant‐derived protease inhibitors and lectins

Plant Lectins with Insecticidal and Insectistatic Activities

Natural coagulants: analysis of potential use for drinking water treatment in developed and developing countries

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