Biotechnology and production-related hormones

Hart, I. C.

doi:10.1079/pns19870054

Cited by 6 publications

(2 citation statements)

References 56 publications

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“…In the first case, hormone replacement therapy, which involves the use of native hormones, is used. Hormones obtained by isolation from tissues or hormones modified by biotechnological methods are used [4,5]. The dose of hormone used usually does not exceed physiological concentrations in blood serum.…”

Section: Introductionmentioning

confidence: 99%

The Potential of Pharmaceutical Hydrogels in the Formulation of Topical Administration Hormone Drugs

Ostróżka-Cieślik

2022

Polymers

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Hormones have attracted considerable interest in recent years due to their potential use in treatment of many diseases. Their ability to have a multidirectional effect leads to searching for new and increasingly effective drugs and therapies. Limitations in formulating drug forms containing hormones are mainly due to their low enzymatic stability, short half-life and limited bioavailability. One of the solutions may be to develop a hydrogel as a potential hormone carrier, for epidermal and transdermal application. This review discusses the main research directions in developing this drug formulation. The factors determining the action of hormones as drugs are presented. An analysis of hydrogel substrates and permeation enhancers that have the potential to enhance the efficacy of hormones applied to the skin is reviewed.

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Section: Introductionmentioning

confidence: 99%

The Potential of Pharmaceutical Hydrogels in the Formulation of Topical Administration Hormone Drugs

Ostróżka-Cieślik

2022

Polymers

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“…Pituitary growth hormone (GH) has been a prime candidate, as it has been repeatedly shown to increase milk production in cows and meat produc¬ tion in cattle, pigs and sheep, and to stimulate wool growth in sheep (Bauman & Currie, 1980;Hart, 1987). Recent advances in recombinant DNA technology have made large quantities of the hormone available and thus the commercial use of GH has become more feasible and practicable.…”

Section: Introductionmentioning

confidence: 99%

Potentiation of the growth-promoting activity of porcine growth hormone (pGH) with an antibody generated in rabbits to the peptide sequence pGH110–118

Wang¹,

Szewczyk²,

Shieh³

et al. 1990

Journal of Endocrinology

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An effort was made to identify the antigenic epitope(s) of porcine GH (pGH) capable of inducing antibodies which would enhance the growth-promoting activity of the hormone. Several peptide sequences of the pGH molecule were synthesized and the antibodies to these peptides were generated in rabbits. The majority of these antibodies were found to be immunoreactive with both intact pGH and their respective peptide antigens. The biological activity of the antibodies was tested in growth-retarded hypophysectomized rats. Daily injections with pGH alone significantly increased their growth rate and treatment with a combination of pGH and antibody specific to the peptide sequence 110-118 further heightened the somatogenic effect. Administration of this antibody alone did not enhance the growth rate of hypophysectomized rats, neither did antibodies raised to intact pGH or the other peptide sequences. The present findings suggest that antibody with a particular pGH epitope specificity is able to increase the somatogenic activity of pGH and that the peptide corresponding to pGH amino acids 110-118 may prove useful in the development of growth promoting vaccines.

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Altering the Efficiency of Milk Production of Dairy Cows With Somatotrophin

Hart¹

1988

Nutrition and Lactation in the Dairy Cow

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Biotechnology and production-related hormones

Cited by 6 publications

References 56 publications

The Potential of Pharmaceutical Hydrogels in the Formulation of Topical Administration Hormone Drugs

The Potential of Pharmaceutical Hydrogels in the Formulation of Topical Administration Hormone Drugs

Potentiation of the growth-promoting activity of porcine growth hormone (pGH) with an antibody generated in rabbits to the peptide sequence pGH110–118

Altering the Efficiency of Milk Production of Dairy Cows With Somatotrophin

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