Biotechnology in the potential practical application of somatotrophic hormones for improving animal performance

Spencer, G. S. G.

doi:10.1051/rnd:19870418

Cited by 7 publications

(4 citation statements)

References 19 publications

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“…It is not therefore surprising that many attempts have been made to increase live weight gains and leanness by treatment with recombinant growth hormone (Spencer 1987). Results have been variable.…”

Section: (B) Growth and Meat Productionmentioning

confidence: 99%

“…They include active immunization against somatostatin, a hormone produced in the hypothalamus that inhibits release of growth hormone. This treatment may produce growth increments of 10-20% in cattle, sheep and pigs (Spencer 1987). Certain monoclonal antibodies have been found to enhance the biological activity of injected growth hormone (Holder et al 1985).…”

Section: (B) Growth and Meat Productionmentioning

confidence: 99%

See 1 more Smart Citation

Animal biotechnology

1989

Phil. Trans. R. Soc. Lond. B

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Biotechnology has taken two directions in efforts to speed up animal production above the rates achievable by selective breeding. Recombinant DNA methods have been used to engineer protein gene products for direct administration to livestock, as in recombinant growth hormone to stimulate lactation in dairy cows or yield faster-growing, leaner carcasses in meat animals. Cloned cellulolytic genes have been inserted into ruminal microorganisms with a view to improving ruminant nutrition. The other direction is to use advanced breeding technologies to enhance performance. These include laboratory culture of large numbers of viable embryos for non-surgical transfer to surrogate mothers, development of methods for sexing sperm and embryos, cloning embryos by nuclear transplantation and gene transfer to create livestock with superior performance traits. In all cases material progress will depend upon a deeper understanding of the underlying physiological and developmental control mechanisms and public confidence that due regard is being paid to animal welfare, and to social and environmental implications.

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Section: (B) Growth and Meat Productionmentioning

confidence: 99%

Section: (B) Growth and Meat Productionmentioning

confidence: 99%

Animal biotechnology

1989

Phil. Trans. R. Soc. Lond. B

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show abstract

“…There is substantial evidence to indicate that, among the various direct and indirect biological activities attributed to the hormone, in ruminants somatotropin also mediates a galactogenic effect (Cotes et al, 1949;Brumby and Hancock, 1955;Machlin, 1972). Recently, the application of recombinant DNA techniques to clone and express the gene for bovine somatotropin (bST) has made it possible to obtain an unlimited amount of hormone and provides an opportunity to investigate benefits that may be derived from control-ling milk production through supplemental administration of bST on a commercial scale (Spencer, 1987). The potential application of this finding to the management of milk production in dairy herds had, however, been hampered by the cost of obtaining limited amounts of somatotropin available through extraction of pituitary glands.…”

mentioning

confidence: 99%

“…Recently, the application of recombinant DNA techniques to clone and express the gene for bovine somatotropin (bST) has made it possible to obtain an unlimited amount of hormone and provides an opportunity to investigate benefits that may be derived from control-0021-856 1/90/1438-1358$02.50/0 ling milk production through supplemental administration of bST on a commercial scale (Spencer, 1987).…”

mentioning

confidence: 99%