Biotechnology Landscape in Cancer Drug Discovery

Neagu, Monica; Albulescu, Radu; Tănase, Cristiana

doi:10.4155/fso.15.10

Cited by 3 publications

(3 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is therefore beneficial to dissect effects experimentally by cell-selective agents. [294][295][296] Furthermore, exploration of molecular concepts cannot be covered by biopharmaceutical industries, due to the fact that the concepts address essentially basic research. 20,289,290 What is the technical maturity of the concepts of CQ use against tumors?…”

Section: Feasibility Of Treating Malignant Tumors With Cq: Strengths mentioning

confidence: 99%

“…292,293 In contrast to genomics, there does not seem to be a major change of research support in sight for high-capacity molecular innovation. [294][295][296] Furthermore, exploration of molecular concepts cannot be covered by biopharmaceutical industries, due to the fact that the concepts address essentially basic research. Research priorities, however, can change in the public sector.…”

Section: Feasibility Of Treating Malignant Tumors With Cq: Strengths mentioning

confidence: 99%

See 1 more Smart Citation

Dissecting pharmacological effects of chloroquine in cancer treatment: interference with inflammatory signaling pathways

2019

View full text Add to dashboard Cite

Chloroquines are 4-aminoquinoline-based drugs mainly used to treat malaria. At pharmacological concentrations, they have significant effects on tissue homeostasis, targeting diverse signaling pathways in mammalian cells. A key target pathway is autophagy, which regulates macromolecule turnover in the cell. In addition to affecting cellular metabolism and bioenergetic flow equilibrium, autophagy plays a pivotal role at the interface between inflammation and cancer progression. Chloroquines consequently have critical effects in tissue metabolic activity and importantly, in key functions of the immune system. In this article, we will review the work addressing the role of chloroquines in the homeostasis of mammalian tissue, and the potential strengths and weaknesses concerning their use in cancer therapy.

show abstract

Section: Feasibility Of Treating Malignant Tumors With Cq: Strengths mentioning

confidence: 99%

Section: Feasibility Of Treating Malignant Tumors With Cq: Strengths mentioning

confidence: 99%

Dissecting pharmacological effects of chloroquine in cancer treatment: interference with inflammatory signaling pathways

2019

View full text Add to dashboard Cite

show abstract

“…In the last years we are facing the development of a myriad of technologies searching for the “golden biomarker.” The omics family is constantly adding a new member, such as genomics, proteomics, peptidomics, newer ones, epigenomics, transcriptomics, metabolomics, lipidomics, pharmacogenomics, interactomics, and chronemics, just mentioning a few [1]. …”

mentioning

confidence: 99%