Biotic potential of mucus extracts of giant mudskipper Periophthalmodon schlosseri (Pallas, 1770) from Pichavaram, southeast coast of India

Mahadevan, Gopalan; Mohan, Kanwar; Jothiprakasam, Vinoth; Ravi, V.

doi:10.1186/s41936-019-0084-4

Cited by 12 publications

(12 citation statements)

References 25 publications

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“…The protein content of mucus extracts of Periophthalmodon schlosseri (Pallas, 1770) showed a great antibacterial activity against eight human pathogenic bacteria (Bacillus anthracis, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Salmonella typhi, Staphylococcus aureus, and Vibrio cholerae) and four fungal strains (Aspergillus flavus, Candida albicans, Mucor sp. and Trichoderma longibriachtin) (Mahadevan et al, 2019). Between bacteria, the highest inhibition zone was observed against P. aeruginosa, S. typhi, with an inhibition zone of 13 and 18 mm, respectively.…”

Section: Antimicrobial Activity In Marine Teleostsmentioning

confidence: 90%

Skin Mucus of Marine Fish as a Source for the Development of Antimicrobial Agents

et al. 2020

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Fish skin mucus is an important component of the innate immune mechanism and provides a first barrier against pathogens. Although several studies investigated and demonstrated the antimicrobial properties of skin mucus of fishes, most of them tested antimicrobial properties against marine microbial strains as potential use in aquaculture. Furthermore, most of these studies concerned freshwater species, and far less attention was given to skin mucus of marine fishes for potential application in human health and research toward its antimicrobial properties. This review outlines the importance of marine fishes as an important and effective source of antimicrobial drugs against several human pathogens, thus providing a highly available and low-cost tool to counteract clinical infections.

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Section: Antimicrobial Activity In Marine Teleostsmentioning

confidence: 90%

Skin Mucus of Marine Fish as a Source for the Development of Antimicrobial Agents

et al. 2020

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“…This latter despite the repertory of biologically active molecules in fish skin mucus (Reverter et al., 2018) and its role in protection against microorganisms (e.g. Mahadevan et al., 2019). This finding agrees with previous results obtained using other mucus donor fish and bacteria (Fuochi et al., 2017).…”

Section: Discussionmentioning

confidence: 99%

Assessing the impacts of skin mucus from Salmo salar and Oncorhynchus mykiss on the growth and in vitro infectivity of the fish pathogen Piscirickettsia salmonis

Levipan

Avendaño‐Herrera

2020

Journal of Fish Diseases

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Piscirickettsiosis is a fish disease caused by the facultative intracellular bacterium, Piscirickettsia salmonis. Even though entry routes of P. salmonis in fish are not fully clear yet, the skin seems to be the main portal in some salmonid species. Despite the importance of fish mucous skin barrier in fighting waterborne pathogens, the interaction between salmonid skin mucus and the bacterium is unknown. This study seeks to determine the in vitro changes in the growth of two Chilean P. salmonis strains (LF‐89‐like and EM‐90‐like genotypes) and the type strain LF‐89T under exposures to skin mucus from Salmo salar and Oncorhynchus mykiss, as well as changes in the cytotoxic effect of P. salmonis on the SHK‐1 cells following exposures. The results suggest that the growth of three P. salmonis strains was not significantly negatively affected under exposures to skin mucus (adjusted at 100 μg total protein ml−1) of O. mykiss (69 ± 18 U lysozyme ml−1) and S. salar (48 ± 33 U lysozyme ml−1) over time. However, the cytotoxic effect of P. salmonis, pre‐exposed to salmonid skin mucus, on the SHK‐1 cell line was reliably identified only towards the end of the incubation period, suggesting that the mucus had a delaying effect on the cytotoxic response of the cell line to the bacterium. These results represent a baseline knowledge to open new avenues of research intended to understand how P. salmonis faces the fish mucous skin barrier.

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“…Even differences in laboratory protocols or conditions of sample storage may affect those characteristics [2,11,12]. Total protein analysis showed a higher protein concentration for the analyzed epidermal mucus of the two ray species when compared to several studies on other fish species [2,[13][14][15]. The protein content in the epidermal mucus may vary based on various stress factors of fishenvironmental factors (e.g.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial properties of bioactive compounds isolated from epidermal mucus in two Ray species (Dasyatis marmorata and Gymnura altavela)

Uyan¹,

Turan²,

Erdogan-Eliuz³

et al. 2020

Trop. J. Pharm Res

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Purpose: To investigate the occurrence and antimicrobial effects of certain biochemical compounds in the epidermal mucus secretions of fish and to demonstrate their potential for biomedical applications.Methods: Crude, aqueous, and acidic epidermal mucus samples were collected from live ray specimens. Gas chromatography and gas chromatography-mass spectrometry (GC/MS) analyses were performed to identify the biochemical compounds present in the mucus. The spectrophotometric broth microdilution method was used to determine the antibacterial and antifungal properties of the mucus extracts. The bacterial strains, Bacillus subtilis, Escherichia coli, Enterococcus faecalis, and Klebsiella pneumonia, were used for the tests, as well as the fungal strains, Candida parapsilosis and Candida albicans.Results: GC/MS analysis revealed the presence of several hydrocarbon-derived compounds in the epidermal mucus of the two ray species. The acidic extract of G. altavela epidermal mucus produced a high MIC value, indicating the highest inhibitory effect of 8.64 μL against E. coli, while the crude extract of G. altavela epidermal mucus (41.13 μL against B. subtilis) was the least effective. Conclusion: Epidermal mucus extracts, especially when acid-based, displays strong antimicrobial properties against all the tested pathogens. These findings suggest the plants possess some potential for the development of novel antimicrobial components for applications in medicine. Keywords: Fish, Ray species, Epidermal mucus, Antimicrobial properties, Bioactive compounds

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Biotic potential of mucus extracts of giant mudskipper Periophthalmodon schlosseri (Pallas, 1770) from Pichavaram, southeast coast of India

Cited by 12 publications

References 25 publications

Skin Mucus of Marine Fish as a Source for the Development of Antimicrobial Agents

Skin Mucus of Marine Fish as a Source for the Development of Antimicrobial Agents

Assessing the impacts of skin mucus from Salmo salar and Oncorhynchus mykiss on the growth and in vitro infectivity of the fish pathogen Piscirickettsia salmonis

Antimicrobial properties of bioactive compounds isolated from epidermal mucus in two Ray species (Dasyatis marmorata and Gymnura altavela)

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