Biotin Administration Improves the Impaired Glucose Tolerance of Streptozotocin-Induced Diabetic Wistar Rats.

Effect of Biotin Treatment on Hepatic Gene Expression in Streptozotocin-Induced Diabetic Rats

“…We have previously reported that biotin administration for 15 d improved the glucose tolerance in STZ rats without enhancing the plasma insulin level. 15) The present result partially corresponds with our earlier observation; however, a single administration of biotin did not affect the plasma glucose level. Both the plasma total cholesterol and triglyceride levels decreased in the biotin-treated group, as compared with the STZ control group, although the differences were not significant ( Table 2).…”

“…We have previously observed that the administration of biotin enhanced hepatic GCK activity by up to 3.4 times in STZ rats. 15) This increase in GCK enzymatic activity could have been due to the enhancement of GCK mRNA expression by the biotin administration. Insulin stimulates lipogenesis by both activating lipogenic enzymes and enhancing their mRNAs.…”

“…13,14) We have previously observed that an intraperitoneal administration of biotin for 15 d partially improved impaired glucose tolerance in response to oral glucose load in STZ-induced diabetic rats and enhanced the enzymatic activities of hepatic and pancreatic GCK without increasing the plasma insulin level. 15) These phenomena might be caused by the modulation of gene expression due to the biotin administration.…”

Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes

“…It also suppresses the expression of hepatic phosphoenolpyruvate carboxykinase, a key gluconeogenic enzyme [34,35]. Biotin administration to diabetic rodents has been reported to improve glycaemic control [36][37][38]. A recent report indicated that biotin supplementation alone reduced plasma triacylglycerol and very low density lipoprotein -cholesterol in subjects with type 2 DM [39].…”

Potentials of some plant-derived foods in the management of diabetes and associated complications

“…Biotin, a nutraceutical agent, has been demonstrated through animal and clinical studies to have the capability of assisting in glycemic control in diabetic individuals if taken at a high dose of 9-15 mg per day (Zhang et al, 1996;Zhang et al, 1997;Maebashi et al, 1993). Various animal studies and few clinical studies established the effect of supplementary magnesium on the preservation of adipocyte insulin sensitivity (McCarty, 2005).…”