“…Incubation of varodione (119) with C. lunata [7d] and C. elegans [30] produced the same polar metabolite, isolated as acetyl derivative, as the result of a 14R,15-dihydroxylation (120, 21% and 11%, respectively). The incubation of the same substrate (119) with F. moniliforme [30] gave ent-11 -(121, 7%), ent-1 -(122, 9%), ent-7 ,11 -(123, 9%), ent-6 ,11 -hydroxylated metabolites (124, 1%), as well as an ent-6 ,12 -dihydroxy-11-oxo derivative (125, 1%), while G. roseum [39] gave rise to mono- hydroxylations only at C-1 (122, 19%) or C-7 (126, 7%), both by the ent-face. R. nigricans [39] yielded a metabolite hydroxylated at C-18 (127, 10%), as well as the ent-7 -hydroxy (126, 4%) and the epoxy derivatives (115, 5%; 116, 6%; 117, 13%; 118, 14%), previously isolated.…”