Biotransformation of Huperzine A by Irpex lacteus-A fungal endophyte of Huperzia serrata

Biologically Significant and Recently Isolated Alkaloids from Endophytic Fungi

“…Endophytic fungi, e.g., Ceriporia lacerata , Bjerkandera adusta , and Irpex lacteus , from H . serrata have been used to effect the biotransformation of 13 to insert, regio- and stereospecifically, an epoxide group at the C-8/C-15 double bond .…”

“…Endophytic fungi, e.g., Ceriporia lacerata , Bjerkandera adusta , and Irpex lacteus , from H . serrata have been used to effect the biotransformation of 13 to insert, regio- and stereospecifically, an epoxide group at the C-8/C-15 double bond . The product, 8α,15α-epoxyhuperzine A ( 15 ), is claimed to be useful as a neuroprotective agent.…”

Biological Activities of Some New Secondary Metabolites Isolated from Endophytic Fungi: A Review Study

“…224-225 exhibited moderate neuroprotective activity by increasing the viability of U251 cell lines with EC 50 values of 35.3 ± 0.9 nM and 32.1 ± 0.9 nM, respectively, while L (EC 50 = 8.3 ± 0.4 nM) exhibited comparable activity with the positive control ibuprofen (EC 50 = 19.4 ± 0.7 nM). The transformed products 224-225 and L all exhibited considerable neuroprotective activity in the invitro LPS-induced neuro-inflammation injury assay, suggesting that the hupA moiety shared by these compounds may be used as a lead structure for the development of neuroprotective drugs [73].…”

“…The biotransformation of lycopodium alkaloid huperzine A (hupA), one of the characteristic bioactive constituents of the medicinal plant Huperzia serrata, by a fungal endophyte of the host plant was studied. Two previously undescribed compounds 224-225 (Figure 7), were isolated and identified [73]. Chemical investigation of the EtOAc extract of the plant-associated fungus Alternaria alternate in rice culture led to the isolation of a new indole alkaloid 226 (Figure 7) [26].…”

Endophytic Fungi-Mediated Biocatalysis and Biotransformations Paving the Way Toward Green Chemistry

“…They reported that the fungal enzymes targeted the rigid ring structure of huperzine B and chemo-enzymatically transformed its structure by hydroxylation and epoxidation reactions. Similar biotransformation reactions of huperzine A mediated by fungal endophyte, Irpex lacteus CCTCCM 2017161, of the host plant was studied by Ying et al (2019) . Also, the biocatalytic efficiency of Penicillium brasilianum in generating active pharmacophores of gentiopicroside and swertiamarin, belonging to iridoid glycosides, has been reported by Xu Z. et al (2020) .…”