Biotransformation of zearalenone and zearalenols to their major glucuronide metabolites reduces estrogenic activity

Frizzell, Caroline; Uhlig, Silvio; Miles, Christopher O.; Verhaegen, Steven; Elliott, Christopher T.; Eriksen, Gunnar Sundstøl; Sørlie, Morten; Ropstad, Erik; Connolly, Lisa

doi:10.1016/j.tiv.2015.01.006

Cited by 65 publications

(52 citation statements)

References 38 publications

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“…a- (Ehrlich et al, 2015). Conjugative metabolism seemed to be a more effective detoxifying route, in accordance to what observed by Frizzell et al (2015) for trans-ZEN glucuronides. Nonetheless, a possible xenoestrogenic activity of cis-ZEN in vivo is conceivable.…”

Section: Interaction Of Cis-zen and Metabolites With The Era-lbdsupporting

confidence: 83%

Hazard identification of cis/trans -zearalenone through the looking-glass

Dellafiora

Galaverna

Dall’Asta

et al. 2015

Food and Chemical Toxicology

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Section: Interaction Of Cis-zen and Metabolites With The Era-lbdsupporting

confidence: 83%

Hazard identification of cis/trans -zearalenone through the looking-glass

Dellafiora

Galaverna

Dall’Asta

et al. 2015

Food and Chemical Toxicology

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“…This has been shown for sulfated ZEN which exerts an uterotropic effect although it is significantly less potent than free ZEN (Plasencia and Mirocha, 1991 , Table 4). Moreover, ZEN-14-O-glucuronide, a-ZEL-14-O-glucuronide, a-ZEL-7-O-glucuronide, b-ZEL-14-O-glucuronide and b-ZEL-16-O-glucuronide were characterized by a low agonist affinity at estrogen receptor ranging from 0.0001% to 0.01% of that of 17b-E2 (Frizzell et al, 2015). The authors concluded that the weak estrogenicity was even lower than that of the corresponding free forms (Table 4).…”

Section: Phase II Metabolites (Conjugated Forms)mentioning

confidence: 99%

Invited review: Diagnosis of zearalenone (ZEN) exposure of farm animals and transfer of its residues into edible tissues (carry over)

Dänicke

Winkler

2015

Food and Chemical Toxicology

106

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“…Moreover, zearalenone was found to negatively affect the reproductive system of males, mostly by decreasing sperm counts and viability (Filannino et al, 2011). However, zearalenone is rapidly metabolized, in particular its glucuronidation represents an important and fast reaction of detoxification (Frizzel et al, 2015). …”

Section: Natural Xenoestrogensmentioning

confidence: 99%

Risks and benefits related to alimentary exposure to xenoestrogens

Paterni

Granchi

Minutolo

2017

Critical Reviews in Food Science and Nutrition

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Xenoestrogens are widely diffused in the environment and in food, thus a large portions of human population is worldwide exposed to them. Among alimentary xenoestrogens, phytoestrogens (PhyEs) are increasingly being consumed because of their potential health benefits, although there are also important risks associated to their ingestion. Furthermore, other xenoestrogens that may be present in food are represented by other chemicals possessing estrogenic activities, that are commonly defined as endocrine disrupting chemicals (EDCs). EDCs pose a serious health concern since they may cause a wide range of health problems, starting from pre-birth till adult lifelong exposure. We herein provide an overview of the main classes of xenoestrogens, which are classified on the basis of their origin, their structures and their occurrence in the food chain. Furthermore, their either beneficial or toxic effects on human health are discussed in this review.

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Biotransformation of zearalenone and zearalenols to their major glucuronide metabolites reduces estrogenic activity

Cited by 65 publications

References 38 publications

Hazard identification of cis/trans -zearalenone through the looking-glass

Hazard identification of cis/trans -zearalenone through the looking-glass

Invited review: Diagnosis of zearalenone (ZEN) exposure of farm animals and transfer of its residues into edible tissues (carry over)

Risks and benefits related to alimentary exposure to xenoestrogens

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