Biotransformations of drugs belonging to nitrogen heterocycles

Abstract

The present review covers general aspects related to the metabolism of organic compounds, primarily, of biologically active azaheterocycles used as drugs. Compounds of this type occupy a dominant place among known drugs. Data on the main chemical processes determining the pathways of principal biotransformations, such as redox reactions, hydrolysis, alkylation, acy lation, various conjugations, isomerizations, and condensations, are summarized. The metabo lisms of heterocycles is considered based on the ring size of the substrate.

Opportunities for Nitric Oxide in Potentiating Cancer Immunotherapy

“…Sydnonimines are meso-ionic heterocyclic compounds, that include molsidomine and 3-morphorlinosydnonimine (SIN-1). In particular, molsidomine that is used as an oral anti-anginal drug is a prodrug that undergoes deacetylation and ring cleavage to release SIN-1 via enzymatic and nonenzymatic reaction (Wang et al, 2002;Granik, 2010). SIN-1 spontaneously decomposes to release NO to exert its biologic effects by consuming oxygen.…”