Bipolar Disorder

Miller, Thomas H.

doi:10.1016/j.pop.2016.02.003

Cited by 29 publications

(22 citation statements)

References 20 publications

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“…First, the study employed a data mining procedure to attain a large sample size (4,191 HS patients, with 5 controls per patient) from a previously authenticated database containing medical information on the majority of Israel's population [20]. Previous studies assessing the association between bipolar disorders and medical comorbidities have focused primarily on physical conditions such as cardiovascular disease, diabetes, chronic obstructive pulmonary disease, or pneumonia [40,41], while less attention has been given to the comorbidity of this disorder with dermatological conditions. This study stresses the importance of investigating these associations to facilitate the diagnosis of such co-occurrence.…”

Section: Discussionmentioning

confidence: 99%

Hidradenitis Suppurativa and Bipolar Disorders: A Population-Based Study

2020

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Background: Psychological comorbidities have been reported in patients with hidradenitis suppurativa (HS), yet only a few studies have investigated the possible association between HS and severe psychiatric disorders. The current study aimed to assess the association between HS and bipolar disorder, a major, chronic, psychiatric disease. Methods: A nationwide, population-based study was performed utilizing data from the Clalit Health Services (CHS) database in Israel. The study included 4,191 HS patients and 20,941 ageand gender-matched controls. A multivariate binary logistic regression, adjusted for demographic and behavioral risk factors, was performed. Results: A higher proportion of bipolar disorders was found among HS patients compared to controls (0.7 vs. 0.1%, respectively). There was an increased proportion of active smokers among HS patients than among controls (53.4 vs. 13.5%, respectively). In the multivariate analysis, adjusting for age, sex, and smoking, HS was found to be independently and positively associated with bipolar disorders (OR 2.12, 95% CI 1.21-3.27, p < 0.01), yet after controlling for body mass this association became nonsignifi-cant. Conclusions: Bipolar disorders are associated with HS. Future studies should explore whether cardiometabolic deficiencies might account for this association. Healthcare providers should consider this potential co-occurrence as it may impede patient compliance and require appropriate screening and treatment. Results also stress the need for a multidisciplinary approach to optimize management of the disease and its associated comorbidities.

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Section: Discussionmentioning

confidence: 99%

Hidradenitis Suppurativa and Bipolar Disorders: A Population-Based Study

2020

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“…Bipolar disorder (BD) is a common, complex, and severe mood disorder with progressive social and cognitive function disturbances . BD is characterized by the presence of mania or hypomania, and episodes of depression.…”

Section: Introductionmentioning

confidence: 99%

“…The gold standard used in the treatment of BD is lithium (Li), which is a mood stabilizer approved by the Food and Drug Administration (FDA) . Previous studies have shown that Li is effective in acute manic episodes, and reduces the risk of manic and depressive relapses …”

Section: Introductionmentioning

confidence: 99%

“…Bipolar disorder (BD) is a common, complex, and severe mood disorder with progressive social and cognitive function disturbances. 1,2 BD is characterized by the presence of mania or hypomania, and episodes of depression. Mania or hypomania is characterized by persistent increases in energy, accompanied by an elevated and expansive or irritable mood.…”

Section: Introductionmentioning

confidence: 99%

“…4 Previous studies have shown that Li is effective in acute manic episodes, and reduces the risk of manic and depressive relapses. 2,5 Despite its importance, little is known about the precise neurobiological underpinnings of BD. However, a considerable number of studies have reported the involvement of glucocorticoids, oxidative stress and inflammatory cytokines in the pathophysiology of BD.…”

Section: Introductionmentioning

confidence: 99%

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Lithium ameliorates sleep deprivation‐induced mania‐like behavior, hypothalamic‐pituitary‐adrenal (HPA) axis alterations, oxidative stress and elevations of cytokine concentrations in the brain and serum of mice

et al. 2017

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Mood Disorders

Reus

2017

Encyclopedia of Life Sciences

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Moods are fundamental emotional states that govern internal experience and adaptive survival. Clinical disorders of mood are prevalent and emerge out of a confluence of genetic, developmental and environmental risk factors to adversely affect morbidity, mortality and function. Current clinical nosologies of mood disorders are based on a categorical rather than dimensional approach to symptomatology and have been shown to have high reliability but lack validation. Advances in the understanding of the neural circuitry underlying regulation of emotion, together with refinements in genetic analysis, neuroimaging and behavioural and biochemical assessment, have contributed to a more comprehensive view of the aetiology of mood disorders and the mechanisms of effective therapeutic interventions. Although the integration of causative factors remains incomplete, current treatment options are numerous and highly effective in the majority of cases. Key Concepts Mood and emotion are terms that have distinct connotations. Mood disorders are highly prevalent and a cause of significant morbidity and mortality. Mood disorders exist on a continuum of intensity and duration of mood change and can be distinguished by the presence or absence of periods of activation and mood elevation, as well as depression. The underlying pathophysiology and genetic underpinnings of mood disorders are increasingly being understood. Mood disorders are highly treatable, using a combination of psychotherapeutic, psychopharmacologic and/or nonpharmacologic interventions.

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Bipolar Disorder

Cited by 29 publications

References 20 publications

Hidradenitis Suppurativa and Bipolar Disorders: A Population-Based Study

Hidradenitis Suppurativa and Bipolar Disorders: A Population-Based Study

Lithium ameliorates sleep deprivation‐induced mania‐like behavior, hypothalamic‐pituitary‐adrenal (HPA) axis alterations, oxidative stress and elevations of cytokine concentrations in the brain and serum of mice

Mood Disorders

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