The response to axial strain of a hollow core photonic band gap fiber(HC-PBF) is investigated. The fiber is designed to operate at 1550nm which have shown to be highly dependent on the exact fiber structure. The relationship between axial strain and confinement loss as well as refractive index is calculated using full vector finite element method. An experimental platform is built to test the effects of axial strain on loss and refractive index, results show that the change rate of loss vs. axial strain is 10(dB/km)/g, and for refractive index is 12.71 × 10-6 /g. Analysis demonstretes that the axial strain has great influence on the loss and the refractive index of HC-PBF, which laid a foundation for HC-PBF optic sensing applications