Birth outcome in women with breast cancer

Abstract

We investigated whether maternal breast cancer affects birth outcome in a nationwide cohort study of 695 births from 1973 to 2002 of women with breast cancer with respect to preterm birth, low birth weight at term, stillbirth and congenital abnormalities as well as mean birth weight, compared with the outcomes of 33 443 births from unaffected mothers. There was no excess risk of adverse birth outcome for the 216 newborns of women with breast cancer before pregnancy. Stratification by mother's treatment did not change the results. For 37 newborns of women diagnosed during pregnancy, the prevalence ratio (PR) of preterm birth was 8.1 (95% confidence interval (CI): 3.8 -17). However, 10 of the 12 preterm deliveries among these women were elective early deliveries. Among 442 births of women diagnosed in the 2 years from time of delivery, the PR of preterm birth was 1.4 (95% CI: 1.0 -2.0), and the PR of low birth weight at term for boys was 2.9 (95% CI: 1.3 -6.3). Overall, our results are reassuring regarding the risks of adverse birth outcome for breast cancer patients.

Pregnancy after breast cancer. A comprehensive review

“…In the series of Velentgas et al [22], the risk of miscarriage was significantly higher for women with a history of breast cancer, when compared with the matched control group (RR 1.7, 24% vs. 18%, P < 0.05). Langagergaard et al [77] conducted a population-based cohort study in which 216 births occurring after breast cancer diagnosis were compared with a matched cohort of 10,453 births by Danish women without previous breast cancer. While exposure to serious periconceptional life events might reduce the male proportion of offspring, partly because of differential abortion of male embryos [78], the sex ratios in the offspring of treated breast cancer patients were equal, similar to those in the comparison cohort.…”

Gravidez após o Cancro da Mama: Estado da Arte

“…3,29 Não está ainda inequivocamente demonstrado que os filhos de mulheres cuja gestação ocorreu após o tratamento para o cancro da mama estejam sujeitos a riscos aumentados no que respeita à sua saúde e alguns estudos epidemiológicos prospetivos observacionais parecem confirmar a ausência de risco. 1,40,41 Não foi evidenciado qualquer aumento do número de recém-nascidos prematuros, recém-nascidos de baixo peso, anomalias congénitas fetais ou morte neonatal. 17,41,42 Porém, no grupo referente a um país europeu, a Suécia, os autores verificaram que apesar da maioria dos filhos destas doentes não apresentarem efeitos adversos, foi detetado um aumento de complicações relacionadas com o parto, aumento da incidência de partos pré-termo e de recém-nascidos de baixo peso.…”

“…1,40,41 Não foi evidenciado qualquer aumento do número de recém-nascidos prematuros, recém-nascidos de baixo peso, anomalias congénitas fetais ou morte neonatal. 17,41,42 Porém, no grupo referente a um país europeu, a Suécia, os autores verificaram que apesar da maioria dos filhos destas doentes não apresentarem efeitos adversos, foi detetado um aumento de complicações relacionadas com o parto, aumento da incidência de partos pré-termo e de recém-nascidos de baixo peso. 20,40 Concluíram que, na sua maioria, estas crianças nascem sem complicações acrescidas; no entanto, estas gestações carecem de vigilância pré-natal especializada por se tratar de gravidezes de alto--risco e, como tal, exigindo referenciação precoce a centro especializado.…”

Pregnancy after Breast Cancer: Myths and Facts

“…There is no evidence that pregnancy in BC survivors is associated with any risk to the infant's health. Data from 2 large population-based cohort studies are rather reassuring in this regard [28,29]. However in the Swedish cohort, an increased risk of delivery complications, caesarean section, very preterm birth (< 32 weeks), and low birth weight (< 1,500 g) were reported compared to healthy controls.…”