Birth prevalence of congenital hypothyroidism in Mexico

Abstract

The Mexican Institute of Social Security (IMSS) provides care for more than 40% of the Mexican population. This report constitutes the first study of the incidence of congenital hypothyroidism (CH) in Mexican children. We performed a prospective study with a population base. CH screening began in 1997 with blood samples from the heel taken 72 h after birth; from 2000, the detection strategy was changed nationwide and blood samples were taken from the umbilical cord in all newborns for determination of thyroid-stimulating hormone (TSH) concentration. We evaluated the annual coverage. TSH concentration was measured by chemoluminescence; TSH values > or =30 microIU/mL in umbilical cord blood and 15 microIU/mL in capillary blood were considered positive cases and were confirmed through hormonal studies. The incidence and 95% confidence intervals [95% CI] were calculated. We found that coverage within the IMSS population was 53% from 1997 to 2000 and had increased to 95% by 2001. A total of 2,777,292 children from 2,975,157 births (93%) were studied between 2000 and 2004. Of these, 4050 had a high TSH concentration leading to suspicion of CH; CH was confirmed in 1286 (32%). The resulting incidence was 4.3/10,000 livebirths [95% CI 3.6, 5.1]. With the results obtained, we conclude that the IMSS strategy of CH screening at birth ensured 95% coverage of children in the system. The birth prevalence of CH reported is among the highest in the world.

Space–time clustering of elevated thyroid stimulating hormone levels

“…An increasing incidence of CHT has been suggested from an analyses of data including that from New York State [2] and Mexico [3], although no similar increase was shown in a similar study of data from Quebec [4]. Previous studies in the United Kingdom have suggested that CHT is more prevalent in Asian sectors of the population and that prevalence has increased [5].…”

Prevalencia al nacimiento de hipotiroidismo congénito

“…17 En México la prevalencia al nacimiento de hipotiroidismo congénito ha sido previamente descrita, sin embargo, dichos estudios datan de hace más de 10 años. 18,19…”

Clinical characteristics of children and adolescents with thyroid disorders seen at the University of Port Harcourt Teaching Hospital: A five year review

“…Disorders of thyroid function in children as in adults manifest as hypothyroidism, hyperthyroidism and varying degree of thyroid gland swelling (goitre) or a combination of these 3 . The frequency of thyroid disorders varies from region to region with higher frequency in Iran, India and Bangladesh and lower frequency in Lativa however, this condition is recorded worldwide 4 . In Nigeria, most studies on thyroid disorders were done in adults.…”