Birth weight, sex and childhood cancer: A report from the United Kingdom Childhood Cancer Study

Smith, Alexandra; Lightfoot, Tracy; Simpson, Jill; Roman, Eve

doi:10.1016/j.canep.2009.10.012

Cited by 36 publications

(35 citation statements)

References 31 publications

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“…Four of the individual studies had already used this method in their original analyses. [26–29] The following variables were considered a priori to be potential confounders or independently competing exposures: birth order, ethnicity, maternal age and education (for maternal analyses); and paternal age and education (for paternal analyses) and were assessed individually for inclusion in the models. Maternal and paternal educations were the only common socio-economic level indicators that were available in all studies.…”

Section: Methodsmentioning

confidence: 99%

Parental occupational paint exposure and risk of childhood leukemia in the offspring: findings from the Childhood Leukemia International Consortium

Bailey

Fritschi

Metayer

et al. 2014

Cancer Causes Control

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Purpose It has been suggested that parental occupational paint exposure around the time of conception or pregnancy increases the risk of childhood leukemia in the offspring. Methods We obtained individual level data from 13 case-control studies participating in the Childhood Leukemia International Consortium (CLIC). Occupational data were harmonized to a compatible format. Meta-analyses of study-specific odds ratios (ORs) were undertaken, as well as pooled analyses of individual data using unconditional logistic regression. Results Using individual data from fathers of 8,185 cases and 14,210 controls, the pooled OR for paternal exposure around conception and risk of acute lymphoblastic leukaemia (ALL) was 0.93 (95% confidence interval (CI) 0.76, 1.14). Analysis of data from 8,156 ALL case mothers and 14,568 control mothers produced a pooled OR of 0.81 (95% CI 0.39, 1.68) for exposure during pregnancy. For acute myeloid leukaemia (AML), the pooled ORs for paternal and maternal exposure were 0.96 (95% CI 0.65, 1.41) and 1.31 (95% CI 0.38, 4.47) respectively, based on data from 1,231 case and 11,392 control fathers and 1,329 case and 12,141 control mothers. Heterogeneity among the individual studies ranged from low to modest. Conclusions Null findings for paternal exposure for both ALL and AML are consistent with previous reports. Despite the large sample size, results for maternal exposure to paints in pregnancy were based on small numbers of exposed. Overall, we found no evidence that parental occupational exposure to paints increases the risk of leukemia in the offspring, but further data on home exposure are needed.

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Section: Methodsmentioning

confidence: 99%

Parental occupational paint exposure and risk of childhood leukemia in the offspring: findings from the Childhood Leukemia International Consortium

Bailey

Fritschi

Metayer

et al. 2014

Cancer Causes Control

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“…In one instance, we computed the latitude coordinates for study centres used and observed a clear north-south pattern but did not test this statistically (Criscione & Weinstock, 2007). Birthweight has also been associated with different childhood cancers suggesting a prenatal source of childhood cancers (Smith et al, 2009;Von Behren & Reynolds, 2003). Rankin et al (2008) report a three-fold increased occurrence of cancer (leukaemia or lymphoma (59%), solid tumour (26%), and brain tumour (15%)) amongst children with some form of congenital abnormality born and living in Northern England, even after exclusion of Down's syndrome cases (Rankin et al, 2008).…”

Section: "Photoperiod" (Latitude At Birth Diagnosis or Death) And Asmentioning

confidence: 99%

Perinatal light imprinting of circadian clocks and systems (PLICCS): A signature of photoperiod around birth on circadian system stability and association with cancer

Lewis

Erren

2017

Chronobiology International

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Recent findings from animal models suggest that plasticity of human circadian clocks and systems may be differentially affected by different paradigms of perinatal photoperiod exposure to the detriment of health in later life, including cancer development. Focusing on the example of cancer, we carry out a series of systematic literature reviews concerning perinatal light imprinting of circadian clocks and systems (PLICCS) in animal models, and concerning the risk of cancer development with the primary determinants of the perinatal photoperiod, namely season of birth or latitude of birth. The results from these systematic reviews provide supporting evidence of the PLICCS and cancer rationale and highlight that investigations of PLICCS in humans are warranted. Overall, we discuss findings from experimental research and insights from epidemiological studies. Considerations as to how to "test" PLICCS in epidemiological studies and as to the potential for non-invasive preventative measures during perinatal periods close our synthesis. If the PLICCS rationale holds true, it opens the exciting prospect for amenable, early-life, preventative measures against cancer development (and other disorders) in later life. Indeed, non-invasive anthropogenic light exposure may have enormous potential to alleviate the public health and economic burden of circadian-related diseases.

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“…Although previous studies have shown that children born with a high birth weight had an elevated risk of brain tumors (1)(2)(3)(4), others have found no association (5)(6)(7)(8). Moreover, it has been reported that children born with a large head circumference had a higher risk of brain tumors (4,9,10), particularly in the first year of life (4,10).…”

Section: Introductionmentioning

confidence: 99%

“…The effect of birth size characteristics, such as birth weight, fetal growth, gestational age, and head circumference, on brain tumor risk has mainly been investigated among children (1)(2)(3)(4)(5)(6)(7)(8). Although previous studies have shown that children born with a high birth weight had an elevated risk of brain tumors (1)(2)(3)(4), others have found no association (5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Birth Size Characteristics and Risk of Brain Tumors in Early Adulthood: Results from a Swedish Cohort Study

Tettamanti

Ljung

Mathiesen

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Despite extensive research on the effect of birth size characteristics on childhood brain tumors, very few studies have evaluated the effect of birth size characteristics on the risk of adult brain tumor, and they have provided inconsistent results.Methods: All individuals born in Sweden between 1973 and 1995 who were still alive and cancer free at their 15th birthday were included in the study (n ¼ 2,032,727). At the end of the study period (December 31, 2010), the study participants were 15 to 37 years old. Incident cases of primary brain tumors were identified through the Swedish Cancer Register.Results: No association was observed between any birth size characteristics and glioma, although an indication of increased glioma risk associated with high birth weight, or being large for gestational age at birth, was found among men [relative risk

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Birth weight, sex and childhood cancer: A report from the United Kingdom Childhood Cancer Study

Cited by 36 publications

References 31 publications

Parental occupational paint exposure and risk of childhood leukemia in the offspring: findings from the Childhood Leukemia International Consortium

Parental occupational paint exposure and risk of childhood leukemia in the offspring: findings from the Childhood Leukemia International Consortium

Perinatal light imprinting of circadian clocks and systems (PLICCS): A signature of photoperiod around birth on circadian system stability and association with cancer

Birth Size Characteristics and Risk of Brain Tumors in Early Adulthood: Results from a Swedish Cohort Study

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